Chem. J. Chinese Universities ›› 2019, Vol. 40 ›› Issue (5): 1065.doi: 10.7503/cjcu20180764
• Polymer Chemistry • Previous Articles Next Articles
ZHU Qinfu, HU Kezhen, LI Xiaojie*(
), CHEN Mingqing
Received:2018-11-14
Online:2019-05-06
Published:2019-04-18
Contact:
LI Xiaojie
E-mail:xjli@jiangnan.edu.cn
Supported by:CLC Number:
TrendMD:
ZHU Qinfu,HU Kezhen,LI Xiaojie,CHEN Mingqing. Preparation of Dendrimer-gold Nanoparticle Composites for pH Responsive Drug Delivery†[J]. Chem. J. Chinese Universities, 2019, 40(5): 1065.
Scheme 1 Synthetic route for PEG-PAMAM(A) and LA-DOX(B)
Scheme 2 Preparation of PEG-PAMAM@AuNPs-LA-DOX nanocomposites
Fig.1 1H NMR spectrum of PEG-PAMAM in D2O(A) and UV-Vis spectra of PEG-PAMAM(a) and PEG-PAMAM@AuNPs(b) in aqueous solution(B) Inset of (B): TEM image of PEG-PAMAM@AuNPs.
Fig.2 1H NMR spectra of intermediate 1(A) and LA-DOX product(B)
Fig.3 UV-Vis spectra of PEG-PAMAM-DOX complex(A), PEG-PAMAM@AuNPs-DOX complex(B), PEG-PAMAM-LA-DOX complex(C) and PEG-PAMAM@AuNPs-LA-DOX complex(D) before(a) and after(b) dialysis in aqueous solution (A), (C) c. PEG-PAMAM; (B), (D) c. PEG-PAMAM@AuNPs.
Scheme 3 pH responsive release of PEG-PAMAM@AuNPs-LA-DOX nanocomposites
Fig.4 Evaluation of drug release profiles for PEG-PAMAM@AuNPs-LA-DOX under physiological and acidic conditions using dialysis method at 37 ℃pH: a. 5.0; b. 7.4.
Fig.5 Cytotoxicity of PEG-PAMAM@AuNPs(), LA-DOX(), DOX() and PEG-PAMAM@AuNPs-LA-DOX() with gradient DOX concentration
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