Chem. J. Chinese Universities ›› 2021, Vol. 42 ›› Issue (10): 3040.doi: 10.7503/cjcu20210379

• Inorganic Chemistry • Previous Articles     Next Articles

Using Human Serum Albumin Nanoparticle as Carrier for co-Delivery of Ru(Ⅲ) Complex and All-trans-retinoic Acid and Its Application for Anti-Metastasis Therapy

DING Xin1, SHI Hongdong2(), LIU Yangzhong1   

  1. 1.Department of Chemistry,University of Science and Technology of China,Hefei 230026,China
    2.College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen 518060,China
  • Received:2021-06-03 Online:2021-10-10 Published:2021-10-10
  • Contact: SHI Hongdong E-mail:honged@szu.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(21907069)

Abstract:

Cancer is one of the main diseases threatening human life and health. Approximately 9.96 million people die from cancer each year in the world. More than 90% of cancer deaths are caused by metastasis. Therefore, the development of effective anti-metastasis drugs is of great significance for cancer treatment. In this paper, a nano-drug system based on human serum albumin(HSANP) was designed and synthesized to co-deliver Ru(Ⅲ) complex and all-trans-retinoic acid(ATRA) for anti-metastatic therapy. Ru-ATRA-HSANP shows excellent stability under water and physiological conditions and could be effectively internalized by cells. It has weak cytotoxicity, but exhibits excellent anti-metastatic effects. In conclusion, an anti-metastatic nanomedicine with good stability and low-toxicity have been constructed, which could be used for anti- metastasis therapy.

Key words: Anti-metastasis, Ru(Ⅲ) complex, All-trans-retinoic acid, Co-delivery, Nanomedicine

CLC Number: 

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