Preparation and Characterization of a Novel Embolic Nano-in-Micro Drug Delivery System

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (11): 2574.

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Preparation and Characterization of a Novel Embolic Nano-in-Micro Drug Delivery System

LIU Yuan-Gang^1,2, MAO Hong-Hao¹, WANG Shi-Bin^1,2*, SUN Xue-Zhan¹

1. College of Chemical Engineering,
2. Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China

Received:2010-11-10 Revised:2011-07-06 Online:2011-11-10 Published:2011-10-14
Contact: WANG Shi-Bin E-mail:sbwang@hqu.edu.cn
Supported by:
国家“八六三”计划项目(批准号: 2006AA02A118), 国家自然科学基金(批准号: 31000441, 31170939), 中央高校基本科研业务费(批准号: JB-JC1009, JB-SJ1009)及福建省自然科学基金(批准号: 2009J01253, 2011J01223)资助.

Abstract

Abstract: A novel poly-L-arginine/chitosan/calcium alginate nano-in-micro(NiM) drug delivery system was prepared using emulsification combined with electrospraying method. Fluorescent labelling test proved that the nano-in-micro structure of NiM was successfully constructed. Bovine serum albumin(BSA) and 5-FU were used as model drugs and the release profiles of NiM as carriers to a single drug and two different drugs were investigated respectively. The results show that the cumulative release rates are 16.3%(5-FU) and 4.9%(BSA) in 0.5 h, and 82.6%(5-FU) and 10.9%(BSA) after 132 h. Zero-order kinetics, first-order kinetics, Ritger-Peppas model and Higuchi model were used to study the release dynamics of these swelling drug delivery systems and Ritger-Peppas model was proved to be the best one which could fit the experimental data effectively. It is concluded that the new NiM system can avoid burst release, slow down the release rate and achieve sequential release of different drugs, and it is expected to have potential applications in drug delivery system.

Key words: Nano-in-micro drug delivery system, Poly-L-arginine, Sodium alginate, Chitosan, Sequential release

CLC Number:

R318

TrendMD:

LIU Yuan-Gang, MAO Hong-Hao, WANG Shi-Bin*, SUN Xue-Zhan. Preparation and Characterization of a Novel Embolic Nano-in-Micro Drug Delivery System[J]. Chem. J. Chinese Universities, 2011, 32(11): 2574.

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Preparation and Characterization of a Novel Embolic Nano-in-Micro Drug Delivery System

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