Preparation and Properties of Nano Lithium Magnesium Silicate-chitosan-sodium Alginate Composite Scaffold Materials

doi:10.7503/cjcu20210184

Abstract

Abstract:

Using vacuum freeze-drying technology， composite scaffolds were fabricated by mixing different mass fractions of nano-lithium magnesium silicate（nLMS） with chitosan and sodium alginate. Results showed that the composite scaffolds were porous solids possessing morphological plasticity， the longitudinal section of the composite scaffold was lamellar， the structure was loose and the internal pores were highly connected. With the increase of nLMS content， the porosity of the composite scaffold decreased and then increased. When the mass fraction of nLMS solution was 3%， both the swelling ratio and the degradation rate of the composite scaffold were the lowest. Besides， the addition of nLMS reduced the toxicity of the composite scaffold. The optimal mass fraction of nLMS solution to prepare the composite scaffold is 3%.

Key words: Bone tissue engineering, Scaffold, Chitosan, Sodium alginate, Lithium magnesium silicate

CLC Number:

O636

TrendMD:

WANG Mingxia, LIU Zhihui, ZHU Zhen, LI Lingfeng, WANG Bowei. Preparation and Properties of Nano Lithium Magnesium Silicate-chitosan-sodium Alginate Composite Scaffold Materials[J]. Chem. J. Chinese Universities, 2021, 42(10): 3240.

Figures/Tables 9

References 21

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