Studies on Spectroelectrochemistry of Adriamycin

Abstract

Abstract: The electrochemical behavior of Adriamycin(ADM) at graphite electrode has been investigated by spectroelectrochemistry and cyclic voltammetry. The electrode reaction mechanism of ADM at different potentials has been described. In the positive potential range, a oneelectron transfer occurs accompanied with a consequent chemical reaction, corresponding to oxidation of hydroquinone functionality to the quinone. At negative potential, Adriamycin involves in a reversible-one electron reduction producing semiquinone species, the latter undergoes a subsequent irreversible chemical reaction with elimination of the glycoside, giving the 7-deoxyadriamycinone, which could be reversibly reduced at more negative potentials. The ECE mechanism has been proposed to explain the electrode reduction process.

Key words: Adriamycin, Spectroelectrochemistry, Cyclic voltammetry, Electrode reaction mechanism

CLC Number:

O657

TrendMD:

FENG Min, HE Pin-Gang, YANG Yu-Lin, FANG Yu-Zhi . Studies on Spectroelectrochemistry of Adriamycin[J]. Chem. J. Chinese Universities, 1999, 20(6): 866.

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Studies on Spectroelectrochemistry of Adriamycin

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