Syntheses and Antitumor Activities of Spin-labeled5-Fluorouracil Derivatives

Abstract

Abstract: Ten new spin-labeled derivatives of 5-fluorouracil(2a-8) were synthesized by introducing four kinds of stable nitroxyl radicals into N₁ and N₃ site of 5-Fu. The structures of these new compounds were confirmed by IR, UV, MS, ESR spectra and elemental analysis. The antitumor activities of these compounds were tested to be against KB, HCT-8 and A 2780. The preliminary results showed that the antitumor activities of compounds 2a and 3a were stronger than that of 5-Fu and were similar to that of HCFU.

Key words: 5-Fluorouracil, Spin-label, Nitroxyl radical, Antitumor activity

CLC Number:

O621

TrendMD:

MAO Man-Jun, TIAN Xuan, CHEN Yao-Zu. Syntheses and Antitumor Activities of Spin-labeled₅-Fluorouracil Derivatives[J]. Chem. J. Chinese Universities, 1998, 19(3): 395.

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Syntheses and Antitumor Activities of Spin-labeled₅-Fluorouracil Derivatives

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