Studies on the Synthesis and Antitumor Activity of Biodegradable Polyphosphamides

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (5): 767.

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Studies on the Synthesis and Antitumor Activity of Biodegradable Polyphosphamides

LUO Yi, ZHUO Ren-xi, FAN Chang-Lie

Department of Chemistry, Wuhan University, Wuhan, 430072

Received:1993-05-17 Revised:1993-11-23 Online:1994-05-24 Published:1994-05-24

Abstract

Abstract: Twelve biodegradable polyphosphamides containing both 5-FUand phosphonoformic acid(or phosphonoacetic acid) ethyl ester were synthesized by condensation of L-lysine 5-FUalkyl(n=3,4,5,6)ester dihydrocmorides with dichloropliosplioric acid ethyl ester,dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester,respectively,in DMFand in the presence of triethylamine. The drug release tests were studied in different pH media. Antitumor activities of monomer and polymers were tested against human hepatoma Bel-7402 cells in vitro.

Key words: Polyphosphamide, 5-Fluorouracil, Drug release, Antitumor activity

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LUO Yi, ZHUO Ren-xi, FAN Chang-Lie. Studies on the Synthesis and Antitumor Activity of Biodegradable Polyphosphamides[J]. Chem. J. Chinese Universities, 1994, 15(5): 767.

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Studies on the Synthesis and Antitumor Activity of Biodegradable Polyphosphamides

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