Preparation and Characterization of a Novel N,O-Carboxymethyl Hydroxypropyl Chitosan Derivative

doi:10.7503/cjcu20120846

Abstract

Abstract:

A novel N,O-carboxymethyl hydroxypropyl chitosan(HPCMS) derivative was prepared through two steps reaction. Water-soluble hydroxypropyl chitosan(HPCS) derivatives with degree of substitution of hydroxypropyl(DS_HP) more than 0.8 were synthesized by reacting chitosan with propylene oxide(PO) using alkali as catalyst; then HPCMS with the DS of carboxymethyl(DS_CM) ranging from 0.42 to 1.38 were prepared by reacting HPCS with chloroacetic acid under alkaline conditions. The structures of the polymers were characterized by FTIR and NMR. The results show that the alkylation mainly occur on the —OH groups at C6 in the reaction of chitosan with propylene oxide; and the —OH groups and —NH₂ groups of HPCS are both alkylated in the reaction of HPCS with sodium chloroacetate.

Key words: Chitosan, Hydroxypropyl chitosan, Carboxymethyl chitosan, Substitution degree

CLC Number:

O636.1

TrendMD:

HAN Xiao-Xiao, PENG Shu-Hua, WU Xiao-Yan, HE Jian-Ping, DENG Ming-Yu, ZHAO Yong-Chao, JIANG Bo. Preparation and Characterization of a Novel N,O-Carboxymethyl Hydroxypropyl Chitosan Derivative[J]. Chem. J. Chinese Universities, 2013, 34(3): 686.

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Preparation and Characterization of a Novel N,O-Carboxymethyl Hydroxypropyl Chitosan Derivative

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