New Tanshinone IIA Delivery System Using Chitosan Nanomicelles of Small Size†

doi:10.7503/cjcu20160288

Abstract

Abstract:

It is still a great challenge to design and synthesize ultra-small chitosan nanoparticles for encapsulating highly hydrophobic neuroprotectants, such as anti-stroke drug tanshinone IIA. To address the issue, a new amphiphilic polymeric micelle system(i.e. CS-g-TPS) was synthesized by covalent linking of D-α-tocopherol succinic acid ester with hydroxylethyl-chitosan in a green and effective approach. The results showed that the obtained CS-g-TPS can be self-assembled into ultra-small nanoparticles by hydrophilic-hydrophobic interaction in aqueous solution, which can be effectively loaded with tanshinone IIA. The particle size and morphology were characterized by scanning electron microscopy(SEM) and dynamic light scattering(DLS), respectively. Bioassays of cell viability and drug uptake further revealed that the CS-g-TPS/tanshinone IIA delivery system could achieve excellent in vitro biocompatibility, as well as high cellular uptake efficiency. It indicated that CS-g-TPS might be a promising drug delivery system for water insoluble neuroprotectant with the characteristics of high biosafety.

Key words: Chitosan nanomicelles of small size, Tanshinone IIA, Neuroprotectant, Delivery for poorly soluble drugs

CLC Number:

O636

TrendMD:

LI Hong, DU Libo, ZHANG Han, ZHAO Yuming, LIU Yang. New Tanshinone IIA Delivery System Using Chitosan Nanomicelles of Small Size^†[J]. Chem. J. Chinese Universities, 2016, 37(7): 1229.

Figures/Tables 3

References 22

[1]	Niaz T., Shabbir S., Rehman A., Rahman A., Nasir H., Imran M., Carbohydrate Polymers,2016, 142, 268—274
[2]	Kinam P., Journal of Control Release, 2007, 120(1/2), 1—3
[3]	Wim H. D., Borm J. A., International Journal of Nanomedicine,2008, 3(2), 133—149
[4]	Avnesh K., Sudesh K. Y., Subhash C. Y., Colloids and Surfaces B: Biointerfaces,2010, 75(1), 1—18
[5]	Suphiya P., Ranjita M., Sanjeeb K., Nanomedicine: Nanotechnology Biology and Medicine,2012, 8(2), 147—166
[6]	Wang J., Zeng Z. W., Xiao R. Z., Xie T., Zhou G. L., Zhan X. R., Wang S. L., Angewandte Chemie International Edition,2014, 53(46), 12320—12364
[7]	Yang J. X., Wang Q., Wang Y. Y., Han S., Yao J. W., Shao S. Q., Wang J. L., Liu Z. H., Guo Y. P., Chem. J. Chinese Universities,2015, 36(5), 1025—1036
	(杨军星, 王琦, 王媛媛, 韩舒, 姚佳伟, 邵思奇, 王敬龙, 刘志辉, 郭玉鹏. 高等学校化学学报, 2015, 36(5), 1025—1036)
[8]	Antonio R., Massimiliano B., Paolo B., Barbara B., Attilio C., International Journal of Pharmaceutics,2013, 455(1/2), 219—228
[9]	Zhang L., Pornpattananangkul D., Hu C. M. J., Huang C. M., Current Medicinal Chemistry,2010, 17, 585—594
[10]	Bhattarai1 N., Gunn J., Zhang M. Q., Advanced Drug Delivery Reviews,2010, 62(1), 83—99
[11]	Avnesh K., Sudesh K. Y., Subhash C. Y., Colloids and Surfaces B: Biointerfaces,2010, 75(1), 1—18
[12]	Qi L. F., Xu Z. R., Jiang X., Hu C. H., Zou X. F., Carbohydrate Research,2004, 339(16), 2693—2700
[13]	Simar K., Rekha R., Afzal H., Sarita K., Journal of Pharmacological Sciences and Research,2011, 3(5), 1227—1232
[14]	Nádia C., Silvaa Sara S., Bruno S., Manuela P., Drug Delivery,2015, 22(7), 885—893
[15]	Hu Y. L., Qi W., Han F., Shao J. Z., Gao J. Q., International Journal of Nanomedicine,2011, 6, 3351—3359
[16]	Zhang H. L., Zhong X. B., Tao Y., Wu S. H., Su Z. Q., International Journal of Nanomedicine,2012, 7, 4069—4076
[17]	Du L. B., Miao X. X., Gao Y. L., Jia H. Y., Liu K., Liu Y., Nanomedicine: Nanotechnology Biology and Medicine,2014, 10, 1411—1420
[18]	Han L., Du L. B., Kumar A., Jia H. Y., Liang X. J., Tian Q., Nie G. J., Liu Y., Biomaterials,2012, 33, 8517—8528
[19]	Zhu L. J., He D. S., Han L. J., Ranslational Stroke Research,2015, 4, 254—256
[20]	Oliveira M. S., Mussi S. V., Gomes D. A., Colloids and Surfaces B: Biointerfaces,2016, 140, 246—253
[21]	Janes K. A., Fresneau M. P., Journal of Controlled Release,2001, 73, 255—267
[22]	Chen L. N., Wang Y., Zhu Y., Sun Y. X., Wang Y. X., Chem. J. Chinese Universities,2013, 34(3), 720—725
	(陈丽娜, 王颖, 朱莹, 孙一新, 王幽香. 高等学校化学学报, 2013, 34(3), 720—725)