Preparation and Characterization of the Chitosan Micropatterns

doi:10.7503/cjcu20120550

Chem. J. Chinese Universities ›› 2013, Vol. 34 ›› Issue (3): 726.doi: 10.7503/cjcu20120550

• Polymer Chemistry • Previous Articles Next Articles

Preparation and Characterization of the Chitosan Micropatterns

LIN Hong, XIE Chao-Ming, LU Xiong, QU Shu-Xin, FENG Bo, WENG Jie

Key Laboratory of Advanced Technologies of Materials(Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

Received:2012-06-07 Online:2013-03-10 Published:2013-02-18
Contact: Lu xiong E-mail:luxiong_2004@163.com

Abstract

Abstract:

Micro-transfer molding was used to prepare four different chitosan(CS) micropatterns on silicon substrates: cylinder, square, groove and sine wave. The as-prepared CS micropatterns were well-formed. Osteoblasts were cultured on various micropatterns to evaluate the effects of micro-geometry on cell behavior. On micro-cylinders and micro-squares, osteoblasts attached on CS micro-dot arrays and displayed irregular morphologies with numerous filopodia-like extensions. These micro-dot arrays had no impact on cell proliferation and differentiation. On micro-grooves and sine wave micropatterns, cells located within the channels and aligned to the direction of channels. Micro-grooves and sine wave micropatterns were unfavorable to cell differentiation, whereas promoted cell proliferation.

Key words: Micropattern, Chitosan, Micro-transfer molding method, Osteoblast

CLC Number:

O631
O636

TrendMD:

LIN Hong, XIE Chao-Ming, LU Xiong, QU Shu-Xin, FENG Bo, WENG Jie. Preparation and Characterization of the Chitosan Micropatterns[J]. Chem. J. Chinese Universities, 2013, 34(3): 726.

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Preparation and Characterization of the Chitosan Micropatterns

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