采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒

doi:10.7503/cjcu20200193

高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (7): 1484.doi: 10.7503/cjcu20200193

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇下一篇

采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒

包寒^1,²,罗静²,时连鑫²,徐福建^1,^*(),王树涛^2,^*()

1.北京化工大学生物医用材料北京实验室, 北京 100029
2.中国科学院理化技术研究所, 中国科学院仿生材料与界面科学重点实验室, 北京 100190

收稿日期:2020-04-08 出版日期:2020-07-10 发布日期:2020-06-08
通讯作者: 徐福建,王树涛 E-mail:xufj@mail.buct.edu.cn;stwang@mail.ipc.ac.cn
基金资助:
国家自然科学基金(21972155);国家高层次人才特殊支持计划

Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate ^†

BAO Han^1,²,LUO Jing²,SHI Lianxin²,XU Fujian^1,^*(),WANG Shutao^2,^*()

1. Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
2. CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Received:2020-04-08 Online:2020-07-10 Published:2020-06-08
Contact: XU Fujian,WANG Shutao E-mail:xufj@mail.buct.edu.cn;stwang@mail.ipc.ac.cn
Supported by:
† National Natural Science Foundation of China(21972155);National Program for Special Support of Eminent Professionals, China

1. ESM to 1484-1491.pdf(463KB)

摘要/Abstract

摘要：

开发了一种制备尺寸均一的多糖基微凝胶(PsMH)的新方法: 以超疏水、高黏附的微米级圆柱状结构硅基底为模板, 通过在微柱结构顶端黏附微液滴, 并在挥发过程中紫外固化, 制备了扁平状的PsMH. 研究发现, 采用此方法制备的PsMH尺寸均一, 且均匀分布在微柱顶端. 通过改变凝胶预聚液浓度及微柱直径, 可以有效调节PsMH的尺寸. 这种多糖基微凝胶有望应用于药物递送及纳米粒子载体等方面.

关键词: 多糖水凝胶, 微米柱状阵列, 微米级凝胶, 超疏水阵列模板

Abstract:

We have demonstrated a novel method for fabricating polysaccharide micro-hydrogel(PsMH) with uniform sizes. Microdroplets were adhered to micro-pillars and UV-cured during droplets evaporation to fabricate bread-like PsMH with uniform micrometer scale sizes via super-hydrophobic, high-adhesion micro-sized cylindrical structure silicon substrate. Results show that the PsMH with narrow size distributes uniformly on the top of the micro-pillars. The sizes and structure of PsMH can be effectively adjusted via polymer concentration and the diameter of micro-pillars. This polysaccharide-based microgel is expected to be used in drug delivery, nanoparticles carrier and other aspects.

Key words: Polysaccharide hydrogel, Micro-pillar, Micro-hydrogel, Super-hydrophobic pillar-structured substrate

中图分类号:

O636
O647

TrendMD:

包寒, 罗静, 时连鑫, 徐福建, 王树涛. 采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒. 高等学校化学学报, 2020, 41(7): 1484.

BAO Han, LUO Jing, SHI Lianxin, XU Fujian, WANG Shutao. Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate ^†. Chem. J. Chinese Universities, 2020, 41(7): 1484.

图/表 10

Scheme 1 Schematic diagram of fabricating polysaccharide micro-hydrogel(PsMH) on cylinder-structured Si substrate

Fig.1 SEM images of top view(A—E) and side view(F—J) and relevant amplified images(insets) of PsMH fabricated on cylinder array with diameters of 3 μm(A, F), 6 μm(B, G), 9 μm(C, H), 12 μm(D, H) and 15 μm(E, J), respectively Mass fraction of the polymer precursor: 40%.

Fig.2 Size(diameter) distribution of PsMH

Fig.3 SEM images of side view of PsMH-310(A), PsMH-910(B), PsMH-1510(C) and PsMH-1540(D)

Table 1 Estimated micro-droplets volumes and polymer mass adhered to the cylinder array and PsMH diameters*

d/μm	V/μm³	m_10%/pg	m_20%/pg	m_30%/pg	m_40%/pg	d_10%/μm	d_20%/μm	d_30%/μm	d_40%/μm
3.0	11.5	0.12	0.23	0.35	0.46	0	0	1.1±0.1	1.0±0.1
6.0	92.1	0.92	1.84	2.76	3.68	0	1.5±0.3	2.1±0.2	2.6±0.3
9.0	310.9	3.11	6.22	9.33	12.43	2.0±0.2	2.9±0.2	3.6±0.3	4.0±0.3
12.0	736.9	7.37	14.74	22.11	29.47	4.4±0.4	5.4±0.4	6.3±0.2	6.8±0.3
15.0	1439.2	14.39	28.78	43.18	57.57	6.2±0.4	6.6±0.3	8.1±0.4	8. 9±0. 5

Fig.4 SEM images and relevant amplified images(insets) of PsMH fabricated on hexagonal pillar-structured Si substrate(A), cylinder-structured PVA(B) and PDMS substrate(C)

Fig.5 SEM images of the top view of PsMH-940(A) and the side view of PsMH-640(B) after being peeled off Insets are relevant amplified images.

Fig.6 Size distribution of the peeled PsMH a. PsMH-340; b. PsMH-640; c. PsMH-940; d. PsMH-1240.

Fig.7 AFM images of PsMH-340(A), PsMH-40(B), PsMH-940(C), PsMH-1240(D) under water

Fig.8 Height maps of PsMH-340(A), PsMH-40(B), PsMH-940(C), PsMH-1240(D) under water

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采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒

Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate ^†

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采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒

Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate †

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Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate ^†