高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (7): 1484-1491.doi: 10.7503/cjcu20200193

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒

包寒1,2,罗静2,时连鑫2,徐福建1,*(),王树涛2,*()   

  1. 1.北京化工大学生物医用材料北京实验室, 北京 100029
    2.中国科学院理化技术研究所, 中国科学院仿生材料与界面科学重点实验室, 北京 100190
  • 收稿日期:2020-04-08 出版日期:2020-07-10 发布日期:2020-06-08
  • 通讯作者: 徐福建,王树涛 E-mail:xufj@mail.buct.edu.cn;stwang@mail.ipc.ac.cn
  • 基金资助:
    国家自然科学基金(21972155);国家高层次人才特殊支持计划

Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate

BAO Han1,2,LUO Jing2,SHI Lianxin2,XU Fujian1,*(),WANG Shutao2,*()   

  1. 1. Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
    2. CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2020-04-08 Online:2020-07-10 Published:2020-06-08
  • Contact: XU Fujian,WANG Shutao E-mail:xufj@mail.buct.edu.cn;stwang@mail.ipc.ac.cn
  • Supported by:
    † National Natural Science Foundation of China(21972155);National Program for Special Support of Eminent Professionals, China

摘要:

开发了一种制备尺寸均一的多糖基微凝胶(PsMH)的新方法: 以超疏水、 高黏附的微米级圆柱状结构硅基底为模板, 通过在微柱结构顶端黏附微液滴, 并在挥发过程中紫外固化, 制备了扁平状的PsMH. 研究发现, 采用此方法制备的PsMH尺寸均一, 且均匀分布在微柱顶端. 通过改变凝胶预聚液浓度及微柱直径, 可以有效调节PsMH的尺寸. 这种多糖基微凝胶有望应用于药物递送及纳米粒子载体等方面.

关键词: 多糖水凝胶, 微米柱状阵列, 微米级凝胶, 超疏水阵列模板

Abstract:

We have demonstrated a novel method for fabricating polysaccharide micro-hydrogel(PsMH) with uniform sizes. Microdroplets were adhered to micro-pillars and UV-cured during droplets evaporation to fabricate bread-like PsMH with uniform micrometer scale sizes via super-hydrophobic, high-adhesion micro-sized cylindrical structure silicon substrate. Results show that the PsMH with narrow size distributes uniformly on the top of the micro-pillars. The sizes and structure of PsMH can be effectively adjusted via polymer concentration and the diameter of micro-pillars. This polysaccharide-based microgel is expected to be used in drug delivery, nanoparticles carrier and other aspects.

Key words: Polysaccharide hydrogel, Micro-pillar, Micro-hydrogel, Super-hydrophobic pillar-structured substrate

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