高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (6): 1378-1383.doi: 10.7503/cjcu20190696

• 高分子化学 • 上一篇    下一篇

通过自由基抑制剂研究聚多巴胺的形成机理

王倩颖,崔树勋*()   

  1. 西南交通大学材料先进技术教育部重点实验室, 成都 610031
  • 收稿日期:2019-12-20 出版日期:2020-06-10 发布日期:2020-04-16
  • 通讯作者: 崔树勋 E-mail:cuishuxun@swjtu.edu.cn
  • 基金资助:
    国家自然科学基金(21774102)

Investigation of Formation Mechanism of Polydopamine by Adding Free Radical Quencher

WANG Qianying,CUI Shuxun*()   

  1. Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China
  • Received:2019-12-20 Online:2020-06-10 Published:2020-04-16
  • Contact: Shuxun CUI E-mail:cuishuxun@swjtu.edu.cn
  • Supported by:
    † National Natural Science Foundation of China(21774102)

摘要:

利用自由基抑制剂二甲基亚砜(DMSO)与依达拉奉(Edaravone)研究了多巴胺(DA)聚合中可能存在的自由基聚合路径, 并考察了pH值对聚合过程的影响. 利用紫外-可见光谱跟踪了反应过程. 研究结果表明, DMSO和Edaravone均可抑制DA的聚合, 而且Edaravone的抑制作用更加显著. 研究结果表明, 自由基聚合路径存在于DA的聚合过程中. 实验还发现, DA的聚合速率随着pH值的升高而增大, 但不同pH值时溶液的最终外观基本一致.

关键词: 多巴胺, 聚合机理, 自由基抑制剂, 自由基聚合

Abstract:

In this paper, by using dimethyl sulfoxide(DMSO) and edaravone as the free radical quencher, the free radical polymerization pathways of dopamine under different pH conditions were studied. Besides, the absorbance of the dopamine solutions was characterized by means of UV-Vis spectroscopy. It is found that the dopamine polymerization rate decreases with the increase of the DMSO concentration, indicating that DMSO can slow down the polymerization of dopamine. Further experiments show that edaravone can slow down the polymerization of dopamine more significantly. These results indicate that the free radical polymerization is one of the possible pathways of dopamine polymerization. Although DMSO can slow down the polymerization of dopamine, it cannot completely restrain the polymerization, which indicates that the polymerization has other reaction pathways besides the free radical polymerization. These pathways may be the main reason for the structure complexity of polydopamine. Moreover, it is found that the polymerization rate increases with the increase of pH and the final reaction products under different pH conditions are similar.

Key words: Dopamine, Mechanism of polymerization, Free radical quencher, Free radical polymerization

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