高等学校化学学报 ›› 2022, Vol. 43 ›› Issue (8): 20220122.doi: 10.7503/cjcu20220122

• 综合评述 • 上一篇    下一篇

偶氮苯类DNA纳米机器

刘苏毓1, 丁飞2, 李茜2,3(), 樊春海2, 冯景4()   

  1. 1.上海理工大学健康科学与工程学院, 上海 200093
    2.上海交通大学化学化工学院, 上海 200240
    3.世界顶尖科学家国际联合实验室, 上海 201203
    4.上海交通大学附属第六人民医院南院, 上海 201499
  • 收稿日期:2022-03-01 出版日期:2022-08-10 发布日期:2022-03-24
  • 通讯作者: 李茜,冯景 E-mail:liqian2018@sjtu.edu.cn;fengjing71921@163.com
  • 基金资助:
    国家自然科学基金(22005136);上海市科学技术委员会重点实验室项目(21dz2210100);中国博士后科学基金(2020M671119)

Azobenzene-integrated DNA Nanomachine

LIU Suyu1, DING Fei2, LI Qian2,3(), FAN Chunhai2, FENG Jing4()   

  1. 1.School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China
    2.School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China
    3.World Laureates Association Laboratories,Shanghai 201203,China
    4.Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus,Shanghai 201499,China
  • Received:2022-03-01 Online:2022-08-10 Published:2022-03-24
  • Contact: LI Qian,FENG Jing E-mail:liqian2018@sjtu.edu.cn;fengjing71921@163.com
  • Supported by:
    the National Natural Science Foundation of China(22005136);the Key Laboratory Project of Shanghai Science and Technology Commission, China(21dz2210100);China Postdoctoral Science Foundation(2020M671119)

摘要:

具备光致异构性及乏氧响应性的偶氮苯为构建DNA纳米机器提供了动态响应元件. 然而, 受限于偶氮苯类化合物有限的光异构化反应, 偶氮苯类DNA纳米机器的构建与应用仍然面临着巨大的挑战. 本文梳理了基于偶氮苯的DNA纳米机器的构建方式及相应优缺点, 总结了可见光响应的偶氮苯类DNA纳米机器的设计规则, 并进一步综合评述了偶氮苯类DNA纳米机器在调控酶活性、 物质运输和机械运动等方面的应用. 本文有望推动开发更灵活的偶氮苯与DNA的偶联方式, 并为偶氮苯类DNA纳米机器在生物医学上的应用带来一定启示.

关键词: 偶氮苯, DNA纳米机器, 光致异构性, 乏氧响应, 可见光响应

Abstract:

Azobenzene-integrated DNA nanomachines have inherited the photo-isomerized and hypoxia-responsive properties of azobenzene, thus enriching methodological toolboxes for designing dynamically responsive nanodevices. However, fabrication of azobenzene-based DNA nanomachine remains challenging due to the limitation of the response mechanism of azobenzene derivatives. This review elaborated the construction methods and corresponding advantages and drawbacks of azobenzene-integrated DNA nanomachine, and summarized the design rules of azobenzene-based DNA nanomachine with visible light-responsive behaviors. Further, the applications of azobenzene-based DNA nanomachine in regulating the activity of biological enzyme, material transport, mechanical motion were reviewed. We expect that this review can facilitate the development of more flexible coupling methods between azobenzene and DNA, and bring inspiration for the biomedicine application of azobenzene-integrated DNA nanomachine.

Key words: Azobenzene, DNA nanomachine, Photoisomerization, Hypoxia-responsive, Visible light-responsive

中图分类号: 

TrendMD: