表面解吸常压化学电离质谱法直接测定火锅底料中的痕量可卡因

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (10): 1961.

表面解吸常压化学电离质谱法直接测定火锅底料中的痕量可卡因

宋庆浩1,3, 王姜2, 胡斌2, 陈焕文2, 金钦汉1

1. 浙江大学工业控制技术国家重点实验室, 智能系统与控制研究所, 分析仪器研究中心, 杭州 310058;
2.东华理工大学应用化学系, 抚州 344000;
3. 山东电力工程咨询院, 济南 250013

收稿日期:2010-02-05 出版日期:2010-10-10 发布日期:2010-10-10
通讯作者: 金钦汉, 男, 教授, 博士生导师, 主要从事光谱分析新方法和新技术研究. E-mail: qhjin@zju.edu.cn
基金资助:
东华理工大学研究生创新资金(批准号: DYCA10002)资助.

Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry for Direct Detection of Trace Amounts of Cocaine in Hot Pot Sauce Materials

SONG Qing-Hao1,3, WANG Jiang2, HU Bin2, CHEN Huan-Wen2, JIN Qin-Han1*

1. Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310058, China;
2. Department of Applied Chemistry, East China Institute of Technology, Fuzhou 344000, China;
3. Shandong Electric Power Engineering Consulting Institute, Jinan 250013, China

Received:2010-02-05 Online:2010-10-10 Published:2010-10-10
Contact: JIN Qin-Han. E-mail: qhjin@zju.edu.cn
Supported by:
东华理工大学研究生创新资金(批准号: DYCA10002)资助.

摘要/Abstract

摘要： 采用表面解吸常压化学电离(SDAPCI)质谱法, 在无需样品预处理情况下, 直接测定了火锅底料中可卡因的含量. 采用取样针取样, 单次取样量在纳升级, 单个样品测定时间少于0.5 min, 回收率为92.9%～106.6%; 相对标准偏差(RSD)为4.7%～11.6%; 可卡因的检出限可达1.5×10-12 g/mL. 该方法适用于批量火锅底料等食品类样品的快速半定量检测.

关键词: 表面解吸常压化学电离源, 质谱, 可卡因, 火锅底料, 快速检测

Abstract: A novel method was developed for the direct detection of cocaine in hot pot sauce materials by surface desorption atmospheric pressure chemical ionization mass spectrometry(SDAPCI-MS) without any sample pretreatment. By using sample needle sampling, the volume of each sampling was at nanoliter level. The ave-rage time for a single sample analysis was less than 0.5 min. The recoveries of six samples spiked with cocaine were shown to be in the range of 92.9%—106.6%, and the relative standard deviations of the method were in the range of 5.2%—11.8%. The detection limit of this method for cocaine was found to be 1.5×10-12 g/mL. The data show SDAPCI-MSn is a powerful tool for rapid, semi-quantitative detection of cocaine in hot pot sauce materials.

Key words: Surface desorption atmospheric pressure chemical ionization, Mass spectrometry, Cocaine, Hot pot sauce materials, Rapid analysis

TrendMD:

宋庆浩, 王姜, 胡斌, 陈焕文, 金钦汉. 表面解吸常压化学电离质谱法直接测定火锅底料中的痕量可卡因. 高等学校化学学报, 2010, 31(10): 1961.

SONG Qing-Hao, WANG Jiang, HU Bin, CHEN Huan-Wen, JIN Qin-Han*. Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry for Direct Detection of Trace Amounts of Cocaine in Hot Pot Sauce Materials. Chem. J. Chinese Universities, 2010, 31(10): 1961.

参考文献

[1]Fernández P., Lafuente N., Cruz A., López-Rivadulla M., Cruz A.. J. Anal. Toxicol[J], 1996, 20(4): 224—228 [2]JIANG He-Ping(蒋和平). Journal of Sichuan University, Natural Science Edition(四川大学学报自然科学版)[J], 2005, 42(4): 794—797 [3]Saito T., Mase H., Takeichi S., Inokuchi S.. J. Pharm. Biomed. Anal.[J], 2007, 43(1): 358—363 [4]FANG Huai-Fang(方怀防), ZENG Zhao-Rui(曾昭睿), LIU Lan(刘岚), PANG Dai-Wen(庞代文). Chem. J. Chinese Universities(高等学校化学学报)[J], 2006, 27(5): 856—858 [5]Jagerdeo E., Abdel-rehim M.. J. Am. Soc. Mass Spectrom.[J], 2009, 20(5): 891—899 [6]Hu B., Peng X. J., Yang S. P., Gu H., Chen H. W., Huan Y. F., Zhang T. T., Qiao X. L.. J. Am. Soc. Mass Spectrom.[J], 2009, 21(2): 290—293 [7]DING Jian-Hua(丁健桦), YANG Shui-Ping(杨水平), LIU Qing(刘清), WU Zhuan-Zhang(吴转璋), CHEN Huan-Wen(陈焕文), REN Yu-Lin(任玉林), ZHENG Jian(郑健), LIU Qing-Jun(刘清珺). Chem. J. Chinese Universities(高等学校化学学报)[J], 2009, 30(8): 1533—1537 [8]CHEN Huan-Wen(陈焕文), LAI Jin-Hu(赖劲虎), ZHOU Yu-Fen(周瑜芬), LI Jian-Qiang(李健强), ZHANG Xie(张燮), LUO Ming-Biao(罗明标), WANG Zhi-Chang(王志畅). Chinese J. Anal. Chem.(分析化学) [J], 2007, 35(8): 1233—1235 [9]Chen H. W., Zheng J., Zhang X., Luo M. B., Wang Z. C., Qiao X. L.. J. Mass Spectrom.[J], 2007, 42(8): 1045—1056 [10]Chen H. W., Liang H. Z., Ding J.H., Qiao X. L.. Journal of Agricultural and Food Chemistry [J], 2007, 55: 10093—10100 [11]YANG Shui-Ping(杨水平), CHEN Huan-Wen(陈焕文), YANG Yu-Ling(杨宇玲), HU Bin(胡斌), ZHANG Xie(张燮), ZHOU Yu-Fen(周瑜芬), ZHANG Li-Li(张丽丽), GU Hai-Wei(顾海威). Chinese J. Anal. Chem.(分析化学) [J], 2009, 37(3): 315—318 [12]YANG Shui-Ping(杨水平), HU Bin(胡斌), LI Jian-Qiang(李建强), HAN Jing(韩京), ZHANG Xie(张燮), CHEN Huan-Wen(陈焕文), LIU Qing(刘清), LIU Qing-Jun(刘清珺), ZHENG Jian(郑健). Chinese J. Anal. Chem.(分析化学) [J], 2009, 37(5): 691—694 [13]LIANG Hua-Zheng(梁华正), CHEN Huan-Wen(陈焕文). Chinese J. Appl. Chem.(应用化学)[J], 2008, 25(5): 519—523 [14]Yang S. P., Ding J.H., Zheng J., Hu B., Li J. Q., Chen H. W., Zhou Z. Q., Qiao X. L.. Anal. Chem.[J], 2009, 81: 2426—2436 [15]WANG Jiang(王姜), YANG Shui-Ping(杨水平), YAN Fei-Yan(鄢飞燕), LIU Yan(刘艳), LI Ming(李明), SONG Yu-Hang(宋宇航), ZHAN Ye-Bing(占叶兵), CHEN Huan-Wen(陈焕文). Chinese J. Anal. Chem.(分析化学)[J], 2010, 38(4): 453—457 [16]Wang P. P., Bartlett M. G.. J. Mass Spectrom.[J], 1998, 33: 961—967