高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (5): 816.

• 研究简报 • 上一篇    下一篇

99mTc水杨醛Schiff碱配合物的制备与生物分布

王明召1, 孟昭兴1, 彭安2, 谭信3   

  1. 1. 放射性药物教育部重点实验室, 北京师范大学化学系, 北京100875;
    2. 北京师范大学生命科学学院, 北京100875;
    3. 北京理工大学生命科学与技术学院, 北京100081
  • 收稿日期:2005-01-05 出版日期:2005-05-10 发布日期:2005-05-10
  • 通讯作者: 王明召(1954年出生),女,博士,副教授,主要从事配位化学和放射性药物研究.E-mail:wang-mzo@bnu.edu.cn E-mail:wang-mzo@bnu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:30270661);放射性药物教育部重点实验室基金资助.

Synthesis and Biodistribution of (99m)Tc Salicylidene Schiff Base Complex

WANG Ming-Zhao1, MENG Zhao-Xing1, PENG An2, TAN Xin3   

  1. 1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing 100875, China;
    2. College of Life Sciences, Beijing Normal University, Beijing 100875, China;
    3. School of Life Sciences and Technology, Institute of Beijing Technology, Beijing 100081, China
  • Received:2005-01-05 Online:2005-05-10 Published:2005-05-10

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关键词: 99mTc, 水杨醛酪氨酸Schiff碱配合物, 合成, 生物分布

Abstract: One novel complex of (99m)Tc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis-and trans-(isomers) might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.

Key words: 99m)Tc, Salicylidene-tyrosine Schiff base complex, Synthesis, Biodistribution

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