高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (7): 1145.

• 论文 •    下一篇

季铵盐型金属卟啉的合成及其对大肠杆菌生长代谢的抑制作用

王磊, 朱训进, 付世涛, 李早英   

  1. 武汉大学化学与分子科学学院, 武汉 430072
  • 收稿日期:2002-06-07 出版日期:2003-07-24 发布日期:2003-07-24
  • 通讯作者: 李早英(1949年出生),女,博士,教授,主要从事金属卟啉的合成及其生物活性的研究.
  • 基金资助:

    国家自然科学基金(批准号:29972035);武汉大学自强创新科学基金(2000年)资助

Synthesis of Water-soluble Metalloporphyrins and Their Inhibiting Action on the Growth Metabolism of E. coli

WANG Lei, ZHU Xun-Jin, FU Shi-Tao, LI Zao-Ying   

  1. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China
  • Received:2002-06-07 Online:2003-07-24 Published:2003-07-24
  • About author:d:\PDF\.pdf

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被引次数

15

摘要： 以5,10,15,20-四(4′-吡啶基)卟啉为原料,合成了一系列季铵盐型金属卟啉1a,1b和2a～2c.使用LKB2277热活性监测器测定了大肠杆菌在不同浓度的金属卟啉1a,1b和2a～2c作用下的产热曲线,得到了大肠杆菌生长速率常数k,最大发热功率Pmax和最大发热功率的出现时间tp,发现季铵盐型金属卟啉2c对大肠杆菌生长代谢的抑制活性明显大于其它季铵盐型金属卟啉.

关键词: 金属卟啉, 合成, 结构表征, 大肠杆菌, 抑制作用

Abstract: Based on 5,10,15,20-(4′-pyridyl)porphyrin, a series of water soluble metalloporphyrins were synthesized. An LKB-2277 Thermal Activity Monitor was used to monitor the cell metabolic activity in vitro to produce thermogenesis curves. The growth rate constants k, maximum heat production rates Pmax and peak time of growth thermogenic curves t of E. coli in different metalloporphyrins at different mass concentrations were deduced from these thermogenesis curves. Metalloporphyrins 1a, 1b and 2a-2c showed an inhibiting action on the growth metabolism of E. coli, with 2c as the best one.

Key words: Metalloporphyrins, Synthesis, Structure characterization, E. coli, Inhibiting action

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