高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (1): 25.

• 研究快报 • 上一篇    下一篇

多吡啶钌(Ⅱ)配合物的合成及其与RNA相互作用的光谱学研究

徐宏1,2, 邓洪1, 胡红雨3, 刘建忠1, 巢晖1, 刘杰1, 计亮年1   

  1. 1. 中山大学化学与化学工程学院, 广州 510275;
    2. 深圳大学师范学院, 深圳 518060;
    3. 中国科学院上海生物化学与细胞生物学研究所, 上海 200031
  • 收稿日期:2002-08-14 出版日期:2003-01-24 发布日期:2003-01-24
  • 通讯作者: 计亮年(1934年出生),男,教授,博士生导师,从事生物无机化学研究.E-mail:cesjln@zsu.edu.cn E-mail:cesjln@zsu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:30070188);广东省自然科学基金(批准号:011217)资助

Studies on the Synthesis and RNA Binding of Ruthenium (Ⅱ) Polypyridine Complexes

XU Hong1,2, DENG Hong1, HU Hong-Yu3, LIU Jian-Zhong1, CHAO Hui1, LIU Jie1, JI Liang-Nian1   

  1. 1. School of Chemistry and Chemical Enginering, Zhongshan University, Guangzhou 510275, China;
    2. Normal College of Shenzhen University, Shenzhen 518060, China;
    3. Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
  • Received:2002-08-14 Online:2003-01-24 Published:2003-01-24

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被引次数

64

关键词: 多吡啶钌(Ⅱ)配合物, RNA, 相互作用

Abstract: A new ruthenium polypyridine complex, [Ru(phen)2(pMIP)]2+(phen=1,10-phenanthroline, pMIP=2-(4-methylphenyl)imidazo phenanthroline), was synthesized and characterized by elementary analysis, MS and 1H NMR. Spectroscopic methods have been carried out on the interaction mechanism of the Ru (Ⅱ) complex with yeast tRNA systematically. The experimental results indicate that the complex binds to yeast tRNA with an intercalative mode possibly, and interacts with yeast tRNA enantioselectively. The experimental results also suggest that spectroscopic method is effective on studying the interaction mechanism of Ru (Ⅱ) complexes with RNA. Information obtained from the study is potentially useful in the design of new RNA-targeting drugs.

Key words: Ruthenium(Ⅱ) polypyridine complex, RNA, Interaction

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