高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (6): 1094.

• 研究简报 • 上一篇    下一篇

由D-Erythorbic Acid合成新的多官能团C4手性筑块

李明霞1, 王言明2, 陈茹玉1   

  1. 1. 南开大学元素有机化学研究所, 天津 300071;
    2. Pittsburgh University Medical Center, Pittsburgh, PA15213, USA
  • 收稿日期:2001-02-23 出版日期:2002-06-24 发布日期:2002-06-24
  • 通讯作者: 陈茹玉(1919年出生),女,教授,博士生导师,中国科学院院士,主要从事有机化学和有机膦化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29972021)资助

Synthesis of New Multifunctional Chiral C4 Building Blocks from D-Erythorbic Acid

LI Ming-Xia1, WANG Yan-Ming2, CHEN Ru-Yu1   

  1. 1. Research Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071, China;
    2. Pittsburgh University Medical Center, Pittsburgh, PA 15213, USA
  • Received:2001-02-23 Online:2002-06-24 Published:2002-06-24

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关键词: D-erythorbic acid, 多官能团, 手性, C4筑块

Abstract: Compounds 4 and 5 which were new selectively protected and multifunctional chiral C4 building blocks were prepared conveniently from commercially available D-erythorbic acid in no more than three steps with satisfied yields. Since compound 4 and compound 5 are densely functionalized and rich in stereochemistry, they are useful chiral building blocks in asymmetric synthesis.

Key words: D-Erythorbic acid, Multifunctional group, Chiral, C-4 building block

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