高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (3): 403.

• 研究论文 • 上一篇    下一篇

1-取代苯基-1,4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲的合成及其抗烟草花叶病毒活性

邹霞娟, 金桂玉, 杨昭   

  1. 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津 300071
  • 收稿日期:2000-12-09 出版日期:2002-03-24 发布日期:2002-03-24
  • 通讯作者: 金桂玉(1935年出生),女,教授,博士生导师,主要从事农药化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29832050)资助

Synthesis of the Thiosemicarbazides of 1-Aryl-1,4-dihydro-3-carboxy-6- methyl-4-pyridazinone and Their Antiviral Activity Against TMV

ZOU Xia-Juan, JIN Gui-Yu, YANG Zhao   

  1. Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:2000-12-09 Online:2002-03-24 Published:2002-03-24

PDF (PC)

摘要： 用1-芳基-1,4-二氢-6-甲基-4-氧哒嗪-3-酰肼与取代苯基异硫氰酸酯反应合成了系列新型取代-1,4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲化合物,其结构经IR,1H NMR及元素分析确认.生物活性测定表明,该类化合物对烟草花叶病毒具有很高的抑制活性.

关键词: 哒嗪酮, 合成, 植物病毒抑制活性

Abstract: Several new thiosemicarbazides of 1-aryl-1,4-dihydro-3-carboxy-6-methyl-4-pyridazinone were synthesized by reaction of hydrazide of 1-aryl-1,4-dihydro-6-methylpyridazin-3-carboxy-4-one with arylisothiocyanates. The structures of compounds were confirmed by IR, 1H NMR spectral data and elemental analyses. The preliminary biological test shows that some compounds (2d, 2l, 2t) possess a high antiviral activity against TMV.

Key words: Pyridazinone, Synthesis, Antiphytoviral activity

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