高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (S1): 168.

• 研究论文 • 上一篇    下一篇

N,N',N"-三香草醛缩三氨乙基胺及其稀土硝酸盐配合物的合成、表征与抗肿瘤活性

台夕市, 唐瑜, 刘伟生, 唐宁, 谭民裕   

  1. 兰州大学化学化工学院, 兰州 730000
  • 收稿日期:2001-07-03 出版日期:2001-12-31 发布日期:2001-12-31
  • 通讯作者: 谭民裕(1933年出生),男,博士,教授,博士生导师,从事稀土化学及配位化学研究.Tel:0931-8912552(0).
  • 基金资助:

    国家自然科学基金(批准号:29871014)资助.

Synthesis, Characterization and Antitumor Activity of The Complexes of Lanthanide Nitrates with Tris{2-[N-(4'-hydroxy-3'-methoxy-phenyl)-methylyimino-ethyl]amine}

TAI Xi-Shi, TANG Yu, LIU Wei-Sheng, TANG Ning, TAN Min-Yu   

  1. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
  • Received:2001-07-03 Online:2001-12-31 Published:2001-12-31

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摘要：

合成了三脚架型席夫碱配体N, N', N"-三香草醛缩三氨乙基胺(C30H33N4O3(OH)3,L)及其稀土 硝酸盐配合物.通过元素分析、红外光潜、核磁共振及热分析谱对它们进行了表征、同时,初步研究了配体及其部分稀土配合物对人体白血病细胞的抑制作用.

关键词: 三脚架配体, 稀土硝酸盐, 配合物, 合成, 性质

Abstract:

A tripodal ligand,Tris{2-[N-(4'-hydroxy-3'-methoxy-phenyl)-methyJyimino-ethyl]-amine (L), and its complexes with lanthanide nitrates have been synthesized. These new complexes with the general formula of Ln(NO3)3L·4H20 (where Ln=La, Pr, Eu, Gd, Tb, Er) were characterized by elemental analysis, IR spectra, thermal analysis and 1H NMR spectra. All the complexes are stable in air. The IR and 1H NMR spectra of the ligand and its complexes show that all the C=N groups take part in coordination to the rare earth ions. The thermal behaviors of the La and Eu complexes are similar. The losses occur at 70~75℃ and 176~185℃ corresponding to the loss of two H2O and two H2O, respectively. The weight losses found in this process compare with the theoretical values, so the complexes have lattice water and coordination water. The antitumor activities of partial complexes have been investigated.

Key words: Tripodal ligand, Lanthanide nitrate, Complexes, Synthesis, Antitumor activity

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