高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (6): 955.

• 研究简报 • 上一篇    下一篇

9-咔唑-羧酸化合物的微波合成及其生物活性研究

劳文剑, 游静, 陆豪杰, 陈淑莲, 沈雪蛟, 欧庆瑜   

  1. 中国科学院兰州化学物理研究所, 兰州 730000
  • 收稿日期:2000-05-23 出版日期:2001-06-24 发布日期:2001-06-24
  • 通讯作者: 欧庆瑜(1934年出生),女,研究员,主要从事色谱及相关技术研究.
  • 基金资助:

    国家自然科学基金(批准号:29870533)资助

Studies on the Synthesis, Properties and Biological Activities of (9-Carbazoly)-carboxylic Acids

LAO Wen-Jian, YOU Jing, LU Hao-Jie, CHEN Shu-Lian, SHEN Xue-Jiao, OU Qing-Yu   

  1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
  • Received:2000-05-23 Online:2001-06-24 Published:2001-06-24

PDF (PC)

被引次数

10

关键词: 微波辐照, 咔唑衍生物, 合成, 抑菌活性

Abstract: This paper investigated a rapid one-pot synthesis method of some substituted(9-carbazoly)-carboxylic acids(3a-3m). The reaction was carried out by mixing of the 9H-carbazoles derivatives with bromo-esters and potassium hydroxide using DMFas solvent under microwave irradiation without catalyst. The optimized experiment conditions were 4-8 min irradiation time and 375 Wmicrowave power. The required range of molar ratio of KOHto substituted carbazole was 3-5. The biological activities of some compounds have been tested. They have medium to weak antimicrobial activities.

Key words: Microwave irradiation, Carbazole derivatives, Synthesis, Antimicrobial activities

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