高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (6): 840.

• 论文 • 上一篇    下一篇

键联环糊精、糖苷的卟啉及金属卟啉的合成

李早英, 李聪, 李立, 王铁锋   

  1. 武汉大学化学系, 武汉 430072
  • 收稿日期:1999-08-02 出版日期:2000-06-24 发布日期:2000-06-24
  • 通讯作者: 李早英(1949年出生),女,博士,副教授,从事生物无机和生物有机化学研究.
  • 基金资助:

    湖北省自然科学基金(批准号:98J043);国家自然科学基金(批准号:29972035)

Synthesis of β-Cyclodextrin and Glucoside Compounds-bonded Porphyrins and Metal Porphyrins

LI Zao-Ying, LI Cong, LI Li, WANG Tie-Feng   

  1. Department of Chemistry, Wuhan University, Wuhan 430072, China
  • Received:1999-08-02 Online:2000-06-24 Published:2000-06-24

PDF (PC)

被引次数

20

摘要： 全甲基化-6-羟基-β-环糊精(PMβ-CD-CH2OH)在N2气流下与三氟甲基磺酸酐反应得到全甲基化-6-三氟甲基磺酸酯-β-环糊精(PMβ-CD-CH2OTf)(6).6分别与5-(p-氨基苯基)-10,15,20-三苯基镍(钌羰基)卟啉[NiTPNH2P](2)和[Ru(CO)TPNH2P](3)缩合得到化合物7和8.1-溴-2,3,4,6-O-乙酰基-α-D-葡萄糖(4)和1-溴-2,3,5-O-乙酰-β-D-呋喃糖(5)分别与H2TPNH2P(1)反应得到化合物9和10.新化合物6—10经IR,UV-Vis,1HNMR和元素分析确证,其中化合物6由MS谱进一步确定.

关键词: &beta, -环糊精, 糖苷, 金属卟啉, 合成

Abstract: The reaction of mono-6-hydroxy permethylated β-cyclodextrin(PM β-CD-CH2OH) with trifluoromethanesulforic anhydride under N2 gave mono 6 trifluoromethanesulfonate permethylated β-cyclodextrin(6). Compound 6 reacted with 5-( p aminophenyl)-10,15,20-triphenyl nickel porphyrin [NiTPNH2 P](2) or 5-( p aminophenyl)10,15,20 triphenyl carbonyl ruthenium porphyrin[Ru(CO)TPNH2 P](3) to produce complexes 7 and 8. 1-Bromo-2,3,5-Oacetyl-β-D-furanoside(4) and 1-bromo-1,2,3,4,6-Oacetyl-α-D-pyranoglucoside(5) respectively reacted with H2TPNH2 P(1) to afford compounds 9 and 10. The new compounds 6—10 were identified by IR, UV-Vis, 1H NMR, elemental analysis, in which compound 6 was determined by MSspectra.

Key words: β-Cyclodextrin, Glucoside compounds, Metal porphyrins, Synthesis

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