高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (8): 1233.

• 论文 • 上一篇    下一篇

3-烷基芳基-6-(1’-N-β-D-或-α-L-吡喃型全乙酰化糖基)-均三唑并[3,4-b]-1,3,4-噻二唑的合成

于建新1, 刘方明1, 鲁文杰1, 李燕萍1, 田丽丽1, 刘育亭1, 刘丛2, 蔡孟深3   

  1. 1. 新疆大学化学系, 乌鲁木齐 830046;
    2. 新疆师范大学化学系, 乌鲁木齐 830011;
    3. 北京医科大学药学院, 北京 100083
  • 收稿日期:1998-12-28 出版日期:1999-08-24 发布日期:1999-08-24
  • 通讯作者: 于建新,男,35岁,博士,副教授.
  • 作者简介:于建新,男,35岁,博士,副教授.
  • 基金资助:

    国家自然科学基金(批准号:29862005);新疆大学自然科学基金

Synthesis of 3-Alkyl/Aryl-6-(1’-N-β-D or α-L-Acetylated glycopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles

YU Jian-Xin1, LIU Fang-Ming1, LU Wen-Jie1, LI Yan-Ping1, TIAN Li-Li1, LIU Yu-Ting1, LIU Cong2, CAI Meng-Shen3   

  1. 1. Department of Chemistry, Xinjiang University, Ulumuqi 830046, China;
    2. Department of Chemistry, Xinjiang Normal University, Ulumuqi 830011, China;
    3. School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, China
  • Received:1998-12-28 Online:1999-08-24 Published:1999-08-24

PDF (PC)

摘要： 通过2,3,4,6-四-O-乙酰基-β-D吡喃型葡萄糖异硫氰酸酯(3)和2,3,4-三-O-乙酰基-α-L-吡喃型鼠李糖异硫氰酸酯(4)与3-烷基/芳基-4-氨基-5-巯基-1,2,4-三唑(5)在乙醇中回流,缩合得到了14个新的3-烷基/芳基-6-(1'-N'-2',3',4',6'-四-O-乙酰基-β-D-吡喃型葡萄糖基或2',3',4'-三-O-乙酰基-α-L-吡喃型鼠李糖基)-均三唑并[3,4-b]1,3,4-噻二唑类化合物(6a_6i,7a_7e),化合物结构经元素分析、IR和1HNMR确证.

关键词: 均三唑并[3, 4-b]-1, 3, 4-噻二唑, 氮苷, 合成

Abstract: 3-Alkyl/aryl-4-amino-5-mercapto-1,2,4-triazoles(5) were condensed with 2,3,4,6-tetra-Oacetyl-β-D-glucopyranosyl isothiocyanate(3) or 2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl isothiocyanate(4) in anhydrous EtO Hunder reflux to afford 14 novel 3-alkyl/aryl-6-(1'-N-2',3',4',6'-tetra Oacetyl-β-D-glucopyranosyl or 1'-N-2',3',4'-tri-O-acetyl-α-L-rhamnopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles(6a_6i, 7a_7e). Their structures were confirmed by elemental analysis, IRand 1HNMR spectral data.

Key words: s-Triazolo[3,4-b] 1,3,4-thiadiazole, N-Glycoside, Synthesis

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