高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (1): 65.

• 论文 • 上一篇    下一篇

反式-2,5-二芳基四氢呋喃合成的新方法

史鸿鑫1, 林辉2, BlochR.3, MandvillG.3   

  1. 1. 浙江工业大学化工学院, 杭州, 310014;
    2. 浙江医科大学机能中心, 杭州, 310006;
    3. Paris-Sud大学Carbocycles实验室, 91405, Orsay Cedex, 法国
  • 收稿日期:1996-12-02 出版日期:1998-01-24 发布日期:1998-01-24
  • 通讯作者: 史鸿鑫,42岁,硕士,副教授.
  • 作者简介:史鸿鑫,42岁,硕士,副教授.
  • 基金资助:

    中法政府科技合作项目资助课题.

A Novel Approach to Synthesize trans-2,5-Diaryltetrahydrofuran

SHI Hong-Xin1, LIN Hui2, Bloch R.3, Mandvill G.3   

  1. 1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014;
    2. Central Laboratory of Biochemistry & Physiological Sciences, Zhejiang Medical University, Hangzhou, 310006;
    3. Lab. des Carbocycles, I. C. M. O. Uniuersite de Paris-Sud, 91405 Orsay Cedex, France
  • Received:1996-12-02 Online:1998-01-24 Published:1998-01-24

PDF (PC)

被引次数

6

摘要： 以(±)4,10-二氧杂三环[5,2,1,02,6]-癸-8-烯-3-醇为原料,经过芳基化、氧化、芳基化、环化、热分解和加氢反应,得到PAF新的拮抗物反式-2,5-二芳基四氢呋喃,并合成了化合物8.

关键词: 二芳基四氢呋喃, 拮抗物, 合成, 手性, 立体选择性

Abstract: A novel approach to synthesize trans-2,5-diaryltetrahydrofuran is described. The new antagonists of PAF are obtained by six step reactions of arylation, oxidation, arylation,cyclization, hot decomposition and hydrogenation starting from (±)4,10-dioxatricyclo [5, 2, 1, 02,6]-dec-8-ene-3-ole is described. Three title compounds (8a-8c) are synthesized.

Key words: Diaryltetrahydrofuran, Antagonist, Synthesis, Chiral, Stereoselectivity

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