高等学校化学学报

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (5): 739.

• 论文 • 上一篇    下一篇

含硅二硫代磷酸酯的合成及生物活性

贺峥杰, 李正名, 毕富春, 王文丽   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1996-06-12 出版日期:1997-05-24 发布日期:1997-05-24
  • 通讯作者: 贺峥杰, 男, 30岁, 博士, 副教授.
  • 作者简介:贺峥杰, 男, 30岁, 博士, 副教授.
  • 基金资助:

    国家自然科学基金

Synthesis and Biological Activity of Silicon-containing Phosphorodithioates

HE Zheng-Jie, LI Zheng-Ming, BI Fu-Chun, WANG Wen-Li   

  1. Elemento-Organic Chemistry Institute, Nankai University, Tianjn, 300071
  • Received:1996-06-12 Online:1997-05-24 Published:1997-05-24

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摘要： 硅基甲硫醇R1R2CH3SiCH2SH与O,O－二烷基二硫代磷酸酯(RO)2P(S)SH及甲醛可顺利地发生类Mannich缩合反应.利用此反应和硅基甲硫醇与O,O－二乙基－S－(2－溴乙基)二硫代磷酸酯的取代反应合成了37种新的含硅二硫代磷酸酯化合物(RO)2P(S)S(CH2)nSCH2SiCH3R1R2(n＝1,2).在初筛浓度下,该类化合物具有一定的杀虫、杀螨活性.

关键词: 有机硅化合物, 二硫代磷酸酯, 合成, 生物活性

Abstract: Silylmethanethiols R1R2MeSiCH2SHsmoothly undergo Mannich-type condensation reaction with O,O-dialkyl phosphorodithioates (RO)2P(S)SHand formaldehyde.By utilizing the above reaction and nucleophilic substitution of O,O-diethyl-S-(2-bromoethyl)phos phorodithioate with silylmethanethiols, 37 novel si1icon-containing phosphorodithioates (RO)2P (S)S (CH2)nSCH2SiMe R1R2 (n = 1, 2) were synthesized.The bioassay results show that the main title compounds possess some insecticidal and acaricidal activities at the preliminary screening concentration.

Key words: Organosilicon compound, Phosphorodithioate, Synthesis, Biological activity

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