高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (5): 705.

• 研究简报 • 上一篇    下一篇

核苷研究(Ⅳ)──辛可芬三唑啉硫酮核苷的立体选择性合成

陈宏明, 张键, 毛建民, 蔡孟深   

  1. 北京医科大学药学院有机教研室, 北京, 100083
  • 收稿日期:1993-08-20 修回日期:1994-01-25 出版日期:1994-05-24 发布日期:1994-05-24
  • 通讯作者: 蔡孟深
  • 作者简介:陈宏明,男,32岁,博士,讲师.

Studies on Nucleosides(Ⅳ)──Stereoselective Syntheses of Cinchophen Triazoline-Thione Nucleosides

CHEN Hong-Ming, ZHANG Jian, AO Jian-Min, CAI Meng-Shen   

  1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083
  • Received:1993-08-20 Revised:1994-01-25 Online:1994-05-24 Published:1994-05-24

关键词: 核苷, 合成, 立体选择性

Abstract: In this paper,trifluoroacetoxy was used as the leaving group of sugar C-1.Seven new nucleosides were synthesized by treating-1-O-trifluoroacetyl-2,3,5-O-tribenzoyl-α-D-ribofuranose(Ⅱ) with 3-cinchophenyl-4-aryl-1,2,4-triazoline-5-thione (Ⅰ) in 1:1 molar ratio at r.t.. Their structures and compositions were characterized by elemental analysis and spectroscopic methods.

Key words: Nucleosides, Synthesis, Stereoselectivity

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