高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (2): 220.

• 论文 • 上一篇    下一篇

稠杂环化合物的研究(X)──3-芳基-6-苯甲酰氨基均三唑并[3,4-b]-1,3,4-噻二唑类化合物的合成及生物活性

张自义1,2, 李明1,2, 赵岚1,2, 李正名3, 廖仁安3   

  1. 1. 南开大学元素有机化学实验室, 天津, 300071;
    2. 兰州大学化学系, 兰州, 730000;
    3. 南开大学元素有机化学研究所, 天津
  • 收稿日期:1993-03-02 修回日期:1993-09-07 出版日期:1994-02-24 发布日期:1994-02-24
  • 通讯作者: 张自义,男, 59岁,教授.
  • 作者简介:张自义,男, 59岁,教授.
  • 基金资助:

    国家自然科学基金

Studies on Condensed Heterocyclic Compounds(X)──Synthesis and Biological Activities of 3-Aryl-6-benzoylamino-striazolo[3,4-b]-1,3,4-thiadiazoles

ZHANG Zi-Yi1,2, LI Ming1,2, ZHAO Lan1,2, LI Zheng-Ming3, LIAO Ren-An3   

  1. 1. Elemento-organic Chemistry Laboratory, Nankai University, Tianjin, 300071;
    2. Deparment of Chemistry, Lanzhou University, Lanzhou, 730000;
    3. The Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin
  • Received:1993-03-02 Revised:1993-09-07 Online:1994-02-24 Published:1994-02-24

PDF (PC)

被引次数

41

摘要： 本文利用3-芳基-4-氨基-5-巯基-1,2,4-均三唑和苯甲酰异硫氰酸酯在无水丙酮中反应,得到一系列3-芳基-6-苯甲酰氨基均三唑并[3,4-b]-1,3,4-噻二唑,用元素分析、IR、1HNMR和MS确定了其结构,提出了可能的反应机制。并对其代表产物2h进行了初步的抗菌和除草实验。

关键词: 均三唑并[3, 4-b]-1, 3, 4-噻二唑, 合成, 机制, 生物活性

Abstract: S-triazolo[3,4-b]-1,3,4-thiadiazoles are fused heterocyclic derivatives showing various biological effect, such as antifungal, antibacterial, hypotensive and CNSdepressant.In view of the pharmacological and synthetic interests of this kind of fused heterocycles, we investigate the reaction of 3-aryl-4-amino-5-mercapto-1,2,4-s-triazoles 1a-j with benzoyl isothiocyanate in the presence of absolute acetone and obtained a series of 3-aryl-6-benzoylamino-s-triazolo[3,4-b]-1,3,4-thiadiazoles,2a-j, whose structures were determined by elemental analysis, IR, 1H NMR and MS.The possible mechanism of this reaction has been suggested in the meantime.It was found that the representative compound 2h has moderate herbicidal activity.

Key words: S-triazolo[3,4-b]-1,3,4-thiadiazoles, Synthesis, Mechanism, Biological activity

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