高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (12): 1792.

• 论文 • 上一篇    下一篇

2－氯/2－甲磺酰基－5－(2－苯基－4－喹啉基)－1,3,4－噁二唑化合物的合成及其亲核取代的研究

张自义1, 冯小明1, 杨丰科1, 管作武2   

  1. 1. 兰州大学化学系, 兰州, 730000;
    2. 北京医科大学药学系
  • 收稿日期:1993-12-24 修回日期:1994-04-28 出版日期:1994-12-24 发布日期:1994-12-24
  • 通讯作者: 张自义,男,60岁,教授.
  • 作者简介:张自义,男,60岁,教授.

Synthesis of 2-Chloro/2-methylsulphonyl-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole Compounds and Their Nucleophilic Displacement

ZHANG Zi-Yi1, FENG Xiao-Ming1, YANG Feng-Ke1, GUAN Zuo-Wu2   

  1. 1. Department of Chemistry, Lanzhou University, Lanzhou, 730000;
    2. Beijing Medical University, Beijing
  • Received:1993-12-24 Revised:1994-04-28 Online:1994-12-24 Published:1994-12-24

PDF (PC)

摘要： 借处理2-羟基-5-(2-苯基-4-喹啉基)-1,3,二唑同PCl5/POCl3之间的反应合成了2-氯-5-(2-苯基-4-喹啉基)-1,3,4-二唑(3)和通过2-基-5-(2-苯基-4-喹啉基)-1,3,4-二唑的甲基化,然后氧化制得2-甲磺酰基-5-(2-苯基-4-喹啉基)-1,3,4-二唑(6).并分别研究了3和6同胺、叠氮及肼的反应,得到2,5-二取代的二唑新衍生物。初步观察了部分化合物的抗菌活性。

关键词: 1, 3, 4－噁二唑, 合成, 亲核取代

Abstract: Substituted compounds of 2-chloro-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole 3 and 2-methylsulphonyl-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole 6 have been synthesized and the reactions of 3 and 6 with a variety of nucleophilic reagent, such as, amine, azide and hydrazine were also investigated. 3 has been prepared by the treatment of 2-hydroxy-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole with PCl5/POCl3. Whereas the 2-methylsulphonyl derivatives 6 has been obtained from 2-mercapto-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole through methylation and subsequent oxidation with KMnO4.

Key words: Oxadiazole, Synthesis, Nucleophilic substitution

TrendMD: