高等学校化学学报

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (5): 573.

• 论文 • 上一篇    下一篇

对-(二甲氨基)苯基锗倍半氧化物的合成、结构及其对体外培养癌细胞的作用

张树功1, 倪嘉缵1, 牛春吉1, 聂毓秀2, 陈玉兰2   

  1. 1. 中国科学院长春应用化学研究所, 130022;
    2. 白求恩医科大学组织胚胎室
  • 收稿日期:1989-11-18 出版日期:1991-05-24 发布日期:1991-05-24
  • 通讯作者: 张树功
  • 基金资助:

    国家自然科学基金

Synthesis and Structure of p-Dimethylaminophenylgermanium Sesquioxide and Its Effect on the Mitotic Activity of Tumor Cell in Vitro

Zhang Shu-gong1, Ni Jia-zuan1, Niu Chun-ji1, Nie Yu-xiu2, Chen Yu-lan2   

  1. 1. Changchun Institute of Applied Chemistry, Academia Sinica, Changchun, 130022;
    2. Tissue Embryon Group, Norman Bethune University of Medical Sciences, Changchun
  • Received:1989-11-18 Online:1991-05-24 Published:1991-05-24

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被引次数

1

摘要： 在常压下,由N,N′-二甲基苯胺和GeCl4合成了对-(二甲氨基)苯基锗倍半氧化物,研究了它的红外光谱、光电子能谱及热分析性质,讨论了化合物的结构.用体外细胞培养法,观察了它对人乳腺癌细胞分裂的抑制作用。

关键词: 对-(二甲氨基)苯基锗倍半氧化物, 合成, 光谱, 结构, 抗癌活性

Abstract: Under atomospheric pressure, the p-dimethylaminophenylgermanium sesquioxide was prepared. The characters of IR, XPS and TG-DTA show that the synthetic compound is the para-monogermanium substitued product. The sesquioxide possesses a higher polymerization degree than Ge-132.In the cell culture of breast carcinoma in vitro, the mitotic activity of tumor cell was obviously inhibited when the concentration of the compound is over 1. 0 mmol.

Key words: p-dimethylaminophenylgermanium sesquioxide, Synthesis, Spectrum, Structure, Antitu-mor reactivity

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