高等学校化学学报

高等学校化学学报 ›› 1988, Vol. 9 ›› Issue (12): 1246.

• 论文 • 上一篇    下一篇

4,5-二氧-(2-硫)-1,3,2,4-二氮二磷杂环戊烷衍生物的合成

陈茹玉, 程磊峰   

  1. 南开大学元素有机化学研究所
  • 收稿日期:1987-07-24 出版日期:1988-12-24 发布日期:1988-12-24
  • 通讯作者: 陈茹玉

Synthesis of 4,5-Dioxo-(2-Thio)-1,3,2,4-Diazadiphosphplanes

Chen Ruyu, Cheng Leifeng   

  1. The Institute of Elementp-Organio Chemistry, Nankai University, Tianjin
  • Received:1987-07-24 Online:1988-12-24 Published:1988-12-24

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摘要： 本文报道了22个新的4,5-二氧-(2-硫)-1,3,2,4-二氮二磷杂环戊烷化合物。对合成路线和条件作了初步探讨。产物的结构经IR、1H和31PNMR及元素分析得到证实,测定了部分产物的MS。在31PNMR谱中产物的顺式和反式异构体均得到了指认。部分产物的生物活性初步测定结果表明,它们具有一定的除草和抑菌活性。

关键词: 合成, 异构体, 线性关系, 生物测定

Abstract: Twenty two hew compounds with the general formula:   have been prepared through the cyclization of alkyl N-alkyl alkylcarbamoylphos-phonamidates with (4-substituted)phenyl dichlorophosphines in the presence of triethylamina and then sulfurization by sulfur. One of these syntheses, in which 6 was obtained by direct sulfurization without the separation of 5, was used.The structures of the products were proved by 1H, 31P NMR, IR, MSandelemental analysis. 31PNMR chemical shift differences ΔδP and IR wavenumberdifferencesΔvP=s showed themselves to correlate with the Taft constant (σ0).respectively This finding was discussed in terms of possible (p→d)π backbonding. It was found that some of these compounds have herbicidal and fungic-idal activities.

Key words: Synthesis, Isomer, Linear relationship, Bioassay

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