高等学校化学学报 ›› 2022, Vol. 43 ›› Issue (12): 20220546.doi: 10.7503/cjcu20220546
收稿日期:
2022-08-19
出版日期:
2022-12-10
发布日期:
2022-09-20
基金资助:
Received:
2022-08-19
Online:
2022-12-10
Published:
2022-09-20
Contact:
HE Yao
E-mail:yaohe@suda.edu.cn
Supported by:
摘要:
快速精准的诊断和高效的治疗对于减轻眼部疾病造成的危害至关重要. 在过去的几十年里, 由于具有尺寸小、 比表面积大、 表面易修饰及独特的光/电子/机械性能等优点, 纳米材料已被用于构建不同种类的高性能纳米探针. 其中, 基于其良好的生物相容性, 科学家们已经将硅纳米材料设计为可用于不同眼部疾病诊断与治疗的功能化纳米探针. 本综述主要概述了将硅基纳米探针用于检测和治疗不同眼部疾病(如角膜疾病、 视网膜疾病、 青光眼等)的近期研究进展. 首先, 重点介绍了硅基纳米探针的设计制备及在角膜新生血管、 细菌性角膜炎等角膜疾病的成像检测与治疗中的应用; 然后, 介绍了用于成像检测和治疗视网膜疾病(如色素性视网膜炎和视网膜新生血管)的硅基持续性给药系统的研究成果; 随后, 概述了多功能硅基纳米载药系统的构建及在青光眼治疗领域的应用研究进展; 最后, 简要讨论了将硅基纳米探针用于眼部疾病诊治面临的挑战并对未来的发展前景进行了展望.
中图分类号:
TrendMD:
储彬彬, 何耀. 硅基纳米探针用于眼部疾病的成像检测与治疗. 高等学校化学学报, 2022, 43(12): 20220546.
CHU Binbin, HE Yao. Silicon-based Nanoprobes for Imaging Detection and Therapy of Ocular Diseases. Chem. J. Chinese Universities, 2022, 43(12): 20220546.
Fig.2 Silicon⁃based nanoprobes for imaging analysis and treatment of corneal NV[60](A) Schematic diagrams of the construction of corneal NV models; (B) slit-lamp images of corneal NV treated with alkaline solution(e.g., NaOH) after 1, 3, 5 and 7 d(scale bars: 5 mm); (C) confocal pictures of fluorescence imaging of corneal NV intravenously treated with pure SiNPs or the prepared SiNPs-RGD probes(scale bars: 25 μm); (D) corresponding slit-lamp images of corneal NV after the treatment with pure saline, SiNPs, RGD and the constructed SiNPs-RGD.Copyright 2018, the American Chemical Society.
Fig.3 Silicon⁃based nanoagents for rapid detection and effective treatment of bacterial keratitis(A) Schematic diagrams of the construction of the SiNPs-based NO delivery system; (B) schematic diagrams of the SiNPs-based NO delivery system for combating bacterial keratitis; (C) the slit-lamp images of bacteria-induced mouse corneas with different treatments[66]; (D) schematic diagrams for illustrating the preparation of SiNPs-Van nanoprobes; (E) confocal pictures of fluorescent imaging of S. aureus-infected or normal mouse corneas after the treatment of the constructed SiNPs-Van; (F) the slit-lamp images of S. aureus-induced mouse corneas after different treatments[67].(A—C) Copyright 2018, the American Chemical Society; (D—F) Copyright 2021, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature.
Fig.4 SiNPs⁃based nanoplatform for the delivery of gene and treatment in RP diseases[77](A) Confocal images of HEK-293 cells after the treatment with the PRPF31-GFP plasmid-lading N-MSiNPs; (B) corresponding confocal images of HEK-293 cells treated with the PRPF31-GFP plasmid-lading N-MSiNPs; (C) fundus images; (D) fluorescence fundus; (E) detail of the injection site showing GFP fluorescent dots; (F) immunostaining of retinal sections. RPE represents retinal pigment epithelium, ONL represents outer nuclear layer, INL represents inner nuclear layer, GCL represents ganglion cell layer.Copyright 2022, Multidisciplinary Digital Publishing Institute.
Fig.5 Fluorescent SiNPs⁃based nanoagents for long⁃term and real⁃time imaging detection of retinal diseases in animal models[72](A) Schematic diagrams of fluorescent SiNPs-based probes; (B) schematic diagrams of the SiNPs probes for visual imaging detection of retina of rats in long term; (C) schematic diagrams of the prepared SiNPs probes for the imaging detection of retinal diseases of cynomolgus macaque; (D) fluorescence fundus images of the SiNPs- or FS-treated retinal vessels; (E) the bright field photograph of choroidal NV diseases of cynomolgus macaque after the treatment with the SiNPs; (F) corresponding fluorescence fundus images of choroidal NV of cynomolgus macaque with the treatment by the SiNPs.Copyright 2021, the Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature.
Fig.6 Long⁃term and real⁃time visualization of fluorescein⁃labeled MSNs moving from the ocular surface through the cornea into the anterior chamber[84](A) Schematic illustration of the main process of SNP@MSNs entering into the eye from the cornea. The NO donor could relax the Schlemm’s canal endothelial cells and trabecular meshwork cells and further induce the reduction of cell volume, resulting in lowering IOP; (B) fluorescence cross-section images of time-course distribution of the fluoresce-labeled MSNs in the mouse eyes. Scale bars: 100 μm. End: cornea endothelium; Epi: cornea epithelium; TM: trabecular meshwork; CB: ciliary body; SC: Schlemm’s canal.Copyright 2018, Wiley-VCH.
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