高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (12): 2598-2609.doi: 10.7503/cjcu20200505

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

质谱技术在反应监测中的发展和应用

艾万鹏, 宋诗瑶, 白玉(), 刘虎威   

  1. 北京分子科学国家实验室, 北京大学化学与分子工程学院, 北京 100871
  • 收稿日期:2020-07-31 出版日期:2020-12-10 发布日期:2020-09-16
  • 通讯作者: 白玉 E-mail:yu.bai@pku.edu.cn
  • 基金资助:
    科技部重大仪器研发专项(2016YFF0100303);国家自然科学基金(21527809);北京市自然科学基金重点项目(Z170002)

Development and Applications of Mass Spectrometry in Reaction Monitoring

AI Wanpeng, SONG Shiyao, BAI Yu(), LIU Huwei   

  1. Beijing National Laboratory for Molecular Sciences,Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Institute of Analytical Chemistry,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China
  • Received:2020-07-31 Online:2020-12-10 Published:2020-09-16
  • Contact: BAI Yu E-mail:yu.bai@pku.edu.cn
  • Supported by:
    ? Supported by the National Key R&D Program of China(2016YFF0100303);the National Natural Science Foundation of China(21527809);Beijing Natural Science Foundation Essential Research Project, China(Z170002)

摘要:

质谱因具有分辨率高、 灵敏度好、 响应快速以及结构鉴定能力强等特点, 近年来在反应监测研究领域应用广泛. 本文介绍了基于质谱的经典在线直接采样实时监测方案; 综合评述了常压质谱离子化技术在反应监测领域的发展和应用, 主要包括基于常压质谱的快反应监测、 微滴加速在长时间反应研究中的应用, 以及其它常压质谱在反应监测中的应用; 并对质谱在反应监测研究领域面临的挑战和发展趋势进行了总结和展望.

关键词: 质谱, 常压质谱, 反应监测, 中间体, 机理

Abstract:

Mass spectrometry has been widely used in reaction monitoring research due to its distinguishing advantages in resolution, sensitivity, speed and structure identification ability in recent years. At first, the applications of mass spectrometriconline sampling in real-time reaction monitoring are introduced. Then the development and applications of ambient mass spectrometry in the reaction monitoring are summarized, inclu-ding the short-time reaction monitoring using ambient mass spectrometry, the long-time organic reaction monitoring using microdroplet acceleration, and the applications of other ambient mass spectrometry in the reaction monitoring. Finally, the challenges and development of mass spectrometry in the field of reaction monitoring are summarized and prospected.

Key words: Mass spectrometry, Ambient mass spectrometry, Reaction monitoring, Intermediate, Mechanism(Ed.: N, K)

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