高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (12): 2648-2657.doi: 10.7503/cjcu20200436

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

核酸适体在癌症诊疗中的研究进展

董倩1,2, 李兆倩1,2, 彭天欢1,2, 陈卓1,2(), 谭蔚泓1,2,3()   

  1. 1.湖南大学化学化工学院, 化学生物传感与计量学国家重点实验室, 2. 分子科学与生物医学湖南省重点实验室, 长沙 410082
    3.上海交通大学医学院分子医学研究院, 附属仁济医院, 上海 200240
    4.中国科学院肿瘤与基础医学研究所, 中国科学院大学附属肿瘤医院, 杭州 310022
  • 收稿日期:2020-07-08 出版日期:2020-12-10 发布日期:2020-12-09
  • 通讯作者: 陈卓 E-mail:zhuochen@hnu.edu.cn;tan@hnu.edu.cn
  • 作者简介:谭蔚泓, 男, 博士, 教授, 中国科学院院士, 主要从事生物分析化学、 化学生物学和分子医学方面的研究. E-mail: tan@hnu.edu.cn
  • 基金资助:
    国家自然科学基金(21522501);湖南省自然科学基金(2018JJ1007)

Progress on Aptamer for Cancer Theranostics

DONG Qian1,2, LI Zhaoqian1,2, PENG Tianhuan1,2, CHEN Zhuo1,2(), TAN Weihong1,2,3()   

  1. 1.State Key Laboratory of Chemo/Bio-Sensing and Chemometrics,College of Chemistry and Chemical Engineering
    2.Hunan Key Laboratory of Molecular Science and Biomedicine Laboratory,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China
    3.Institute of Molecular Medicine(IMM),Renji Hospital,School of Medicine,College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200127,China
  • Received:2020-07-08 Online:2020-12-10 Published:2020-12-09
  • Contact: CHEN Zhuo E-mail:zhuochen@hnu.edu.cn;tan@hnu.edu.cn
  • Supported by:
    ? Supported by the National Natural Science Foundation of China(21522501);the Natural Science Foundation of Hunan Province, China(2018JJ1007)

摘要:

核酸适体是通过体外筛选技术得到的可特异性结合靶标分子的单链寡核苷酸分子探针, 其表现出与抗体相当或更优异的特异性和亲和力, 且具有靶标范围广、 免疫原性低、 易于精准制备和修饰及设计灵活可控等优势. 为癌症的早期筛查、 诊断及靶向治疗提供了全新的分子工具, 在癌症诊疗领域获得了广泛的关注与应用. 本文聚焦核酸适体在癌症诊断及治疗中的应用, 对近年来取得的研究进展进行了系统性总结, 并对未来发展方向及前景进行了展望.

关键词: 核酸适体, 靶向治疗, 分子探针, 癌症诊断与治疗

Abstract:

Aptamers are single-stranded oligonucleotides selected through a process known as Systematic Evolution of Ligands by Exponential enrichment(SELEX), showing a high selectivity towards their target molecules. The selectivity and affinity of aptamers are comparable to antibodies and even higher. They have the advantages of multiple targets, low immunogenicity, ease of accurate synthesis and modification, flexible and controllable design, which endow them as new molecular tools for early screening, diagnosis and targeting therapy. Therefore, aptamers have attracted extensive attention and have been applied in the field of cancer diagnosis and treatment. This review focused on the applications of aptamers in cancer diagnosis and treatment, and summarized systematically the research progresses made in recent years and discussed the prospective of the future development.

Key words: Aptamer, Targeting therapy, Molecular probe, Cancer diagnosis and treatment

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