人工调控细胞表面受体聚集状态及功能

doi:10.7503/cjcu20190673

摘要/Abstract

摘要：

从利用物理刺激和生物大分子诱导两个方面综述了人工调控细胞表面受体聚集状态的策略. 前者是利用相应的纳米材料在光、磁场、温度等物理刺激作用下实现人工调控受体聚集; 后者则利用包括蛋白/多肽类分子、核酸在内的生物分子的自组装对其靶向识别的受体进行人工调控. 系统介绍了相关研究领域取得的最新进展, 并阐述和展望了该领域现存的挑战和发展方向.

关键词: 受体聚集, 人工调控, 功能, 细胞表面

Abstract:

In this review, various strategies for artificial regulation of receptor clustering on cell surface are introduced, which are realized either by physical-stimulations or biological macromolecules. The former one is induced by stimuli-responsive nanomaterials under physical stimulation, such as light, magnetic field, and heat. And the later one is achieved by utilizing the self-assembly of biomolecules including protein, peptide or nucleic acids, thus inducing artificial regulation of their targeting receptor. We aim to systematically introduce advances in this area and provide insights into the existing challenges and future perspectives.

Key words: Receptor clustering, Artificial regulation, Function, Cell surface

中图分类号:

O656.9

李婧影, 陈琛, 李娟, 杨黄浩. 人工调控细胞表面受体聚集状态及功能[J]. 高等学校化学学报, 2020, 41(5): 892-900.

LI Jingying, CHEN Chen, LI Juan, YANG Huanghao. Artificial Regulation of Receptor Clustering and Function on Cell Surface ^†[J]. Chemical Journal of Chinese Universities, 2020, 41(5): 892-900.

图/表 4

Fig.1 Schematic representation of artificial regulating receptor clustering on cell surface

Fig.2 Chemical structure of PCGlue-NBD and schematic illustration of the mechanistic role of PCGlue-NBD for turning off and on Met dimerization caused by the interaction between Met and its ligand HGF(A)[23], schematic representation of nano-aAPC synthesis by coupling MHC-Ig dimers and co-stimulatory anti-CD28 to iron-dextran nanoparticles(B)[31] (A) Copyright 2019, American Chemical Society; (B) Copyright 2014, American Chemical Society.

Fig.3 Schematic representation of DNA-based HGF mimetic(A)[49] and FGFR activation induced by FGF(left) or designed aptamer assemblies(right)(B)[50], DRIPaR for inducing thrombin-dependent Met activation, and their influences in the p-Met expression level in A549 cells(C)[51], histidine or Zn2+ DNAzyme-based D-CID of Met activation(D)[52] (A) Copyright 2016, John Wiley and Sons; (B) Copyright 2019, Royal Society of Chemistry; (C) Copyright 2017, American Chemical Society; (D) Copyright 2018, John Wiley and Sons.

Fig.4 Schematic representation of logic-based aptamer-controlled receptor assembly for modulation of cellular signal transduction(A)[53] and photo-controlled DNA assembly approach for the receptor dimerization and signaling activation(B)[54], BAAP strategy to selectively regulate Met receptor function and downstream signaling pathways(C)[56] (A) Copyright 2019, John Wiley and Sons; (B) Copyright 2018, John Wiley and Sons; (C) Copyright 2019, American Chemical Society.

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