高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (5): 892-900.doi: 10.7503/cjcu20190673

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

人工调控细胞表面受体聚集状态及功能

李婧影1,2,陈琛1,2,李娟1,*(),杨黄浩1   

  1. 1. 福州大学化学学院, 食品安全与生物分析教育部重点实验室
    2. 生物科学与工程学院, 福州 350108
  • 收稿日期:2019-12-16 出版日期:2020-05-10 发布日期:2020-03-19
  • 通讯作者: 李娟 E-mail:lijuan@fzu.edu.cn
  • 基金资助:
    国家自然科学基金(21974022);国家自然科学基金(91959102);国家自然科学基金(21635002)

Artificial Regulation of Receptor Clustering and Function on Cell Surface

LI Jingying1,2,CHEN Chen1,2,LI Juan1,*(),YANG Huanghao1   

  1. 1. College of Chemistry, Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education
    2. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China
  • Received:2019-12-16 Online:2020-05-10 Published:2020-03-19
  • Contact: Juan LI E-mail:lijuan@fzu.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(21974022);† Supported by the National Natural Science Foundation of China(91959102);† Supported by the National Natural Science Foundation of China(21635002)

摘要:

从利用物理刺激和生物大分子诱导两个方面综述了人工调控细胞表面受体聚集状态的策略. 前者是利用相应的纳米材料在光、 磁场、 温度等物理刺激作用下实现人工调控受体聚集; 后者则利用包括蛋白/多肽类分子、 核酸在内的生物分子的自组装对其靶向识别的受体进行人工调控. 系统介绍了相关研究领域取得的最新进展, 并阐述和展望了该领域现存的挑战和发展方向.

关键词: 受体聚集, 人工调控, 功能, 细胞表面

Abstract:

In this review, various strategies for artificial regulation of receptor clustering on cell surface are introduced, which are realized either by physical-stimulations or biological macromolecules. The former one is induced by stimuli-responsive nanomaterials under physical stimulation, such as light, magnetic field, and heat. And the later one is achieved by utilizing the self-assembly of biomolecules including protein, peptide or nucleic acids, thus inducing artificial regulation of their targeting receptor. We aim to systematically introduce advances in this area and provide insights into the existing challenges and future perspectives.

Key words: Receptor clustering, Artificial regulation, Function, Cell surface

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