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Split Intein： a Versatile Tool for Traceless Peptide Segment Ligation HAN Dongyang, REN Yuxiang, YANG Ziyi, HUANG He, ZHENG Jishen Chem. J. Chinese Universities    2023, 44 (10): 20230188-.   DOI: 10.7503/cjcu20230188 Abstract （1895）   HTML （98）    PDF（pc） （5394KB）（2991）       Knowledge map    Save Split intein can efficiently ligate peptide segments via a splicing reaction in a traceless manner and therefore has attracted great attention. Based on the structural characteristics and splicing reaction process of split intein， this paper comprehensively reviewed the recent progresses on the performance optimization and expanded applications of split intein， and revealed its great potential in the field of chemical protein synthesis as an increasingly sophisticated protein engineering technology. Finally， the challenges presented in the split intein- mediated protein trans-splicing and potential solutions in the future research were briefly discussed. Table and Figures | Reference | Related Articles | Metrics

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Progress on the Stereocontrolled Synthesis of Phosphorothioate Oligonucleotides CAO Shujie, LI Hongjun, GUAN Wenli, REN Mengtian, ZHOU Chuanzheng Chem. J. Chinese Universities    2023, 44 (3): 20220304-.   DOI: 10.7503/cjcu20220304 Abstract （1755）   HTML （40）    PDF（pc） （3881KB）（980）       Knowledge map    Save Phosphorothioate（PS） oligonucleotides have found a wide range of applications in biochemical mechanism studies， biomedicine， materials and related fields. The stereo configuration of PS has a remarkable effect on the biochemical properties of PS nucleic acids， which has aroused wide interest in developing methods for efficient and stereoselective synthesis of PS oligonucleotides in the past 30 years. This review summarized the methods for stereocontrolled synthesis of PS oligonucleotides， with a focus on the research progress in the past decade. The advantages and disadvantages of different methods were comparatively analyzed. Finally， the prospect of stereocontrolled synthesis of PS oligonucleotides was briefly discussed. Table and Figures | Reference | Related Articles | Metrics

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Electrocatalytic Oxidative Cleavage of Lignin： Facile and Efficient Biomass Valorization Strategy XU Jianing, BAI Wenjing, LOU Yuhan, YU Haipeng, DOU Shuo Chem. J. Chinese Universities    2023, 44 (5): 20220749-.   DOI: 10.7503/cjcu20220749 Abstract （1655）   HTML （54）    PDF（pc） （5356KB）（1839）       Knowledge map    Save Lignin， as an intriguing native renewable aromatic polymer， can be depolymerized into aromatic platform chemicals by catalysis procedures， and its high-value conversion is of great significance for realizing the green and sustainable production of biofuels， fine chemicals， and bulk chemicals. With this regard， catalytic oxidation of lignin through electrochemistry offers an economized energy nature with tunable potential or current to determine the products selectivity and conversion rate. However， to realize the controllable degradation of lignin， the electrocatalytic system， including the catalysts， electrolyte， reaction cell， etc.， should be rationally designed based on the well-understanding of the depolymerization mechanism. In this review， we focused on the bond cleavage mechanism of C—C bond and C—O bond， respectively， in the depolymerization of lignin. Research works based on the different bond cleavage mechanisms in the electrochemical oxidation of lignin and its model compounds to aromatic monomers in recent years were reviewed here， including the different types of catalytic systems， electrocatalysts， and free radical initiators. Of which the free radical intermediates play decisive role in the highly selective cleavage of C—O and C—C bonds. Finally， the challenges and development perspectives in the future of electrocatalytic lignin depolymerization are also provided. Table and Figures | Reference | Related Articles | Metrics

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Recent Process of Carbon-based Catalysts for the Production of H2O2 by Electrocatalytic Oxygen Reduction： Strategies， Calculation and Practical Applications ZHANG Xiaoyu, QU Gan, XUE Dongping, YAN Wenfu, ZHANG Jianan Chem. J. Chinese Universities    2023, 44 (5): 20220775-.   DOI: 10.7503/cjcu20220775 Abstract （1648）   HTML （80）    PDF（pc） （12402KB）（471）       Knowledge map    Save Hydrogen peroxide（H2O2） as a multifunctional and environmentally friendly oxidizer， plays a crucial role in industrial production， bleaching， disinfection， and wastewater treatment， etc. The traditional anthraquinone process is not the ideal choice for batch H2O2 production due to the disadvantages of environmental pollution， insecurity， and complicated process. Typically， H2O2 can be synthesized by the 2-electron（2e‒） oxygen reduction reaction（ORR） process， which process is a promising alternative to produce the H2O2 at a large scale. Carbon-based materials are considered as one kind of the best catalysts for 2e‒ ORR due to their abundant reserves， low cost， adjustable structure， and good conductivity. Therefore， this paper reviews the research progress of carbon-based catalysts in 2e‒ ORR for H2O2. Firstly， the basic principle of 2e‒ ORR is introduced， and the key factors affecting the ORR path are revealed. Then， density functional theory（DFT） employed to reveal the essence of catalytic active sites is introduced. After that， several effective strategies on catalysts for promoting the production of H2O2 are summarized in detail， including optimized single atom catalysts（SACs）， defect engineering on catalyst surface， pyrrole nitrogen doping， oxygen-containing functional groups doping， and other heteroatoms（e.g. S， P， F） doping. At last， the deve-lopment of the practical applications in the devices for mass production of H2O2 are discussed. Finally， the potential opportunities and challenges in the future development of electrochemical synthesis of H2O2 are proposed. Table and Figures | Reference | Related Articles | Metrics

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Hydrogel-based Bioinspired Ion Channels： Fabrication and Controllable Ion Transport CHEN Weipeng, KONG Xiangyu, WEN Liping Chem. J. Chinese Universities    2023, 44 (6): 20220772-.   DOI: 10.7503/cjcu20220772 Abstract （1637）   HTML （71）    PDF（pc） （14959KB）（1078）       Knowledge map    Save The controllable ion transport is the basis of most physiological activities， such as the transmission of neural signals， the perception of external stimuli， etc. The key to realize the controllable ion transport is the various protein ion channels in life system. Inspiring researchers endeavor to develop artificial ion channels to subtly tune the ion transportation. Among the developed ion channels， hydrogel-based system exhibits the advantages of high ion selectivity and high ion conductance due to its three-dimensional（3D） charged networks induced space charges and 3D interconnection channels. As hydrogel-based ion channels hold the biocompatibility， deformability， and stable ion storage properties， it has been the focus in intelligence ion transport field and shows great potential in ion electronic circuits， medical health， energy conversion and storage， resources， and environment. To summarize the latest development of the hydrogel-based ion channels， we firstly overview on the construction methods of hydrogel-based intelligent ion channels. Thereafter， the ion transport mechanisms in the hydrogel-based ion channels are summarized， and the applications of such ion channels are categorized. At last， we discuss the existed issues and give the perspective on future development of hydrogel-based ion channels. Table and Figures | Reference | Related Articles | Metrics

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Research Advances in Transport Mechanism of Lithium Ions in Solid Electrolytes FU Zhongheng, CHEN Xiang, YAO Nan, YU Legeng, SHEN Xin, ZHANG Rui, ZHANG Qiang Chem. J. Chinese Universities    2023, 44 (5): 20220703-.   DOI: 10.7503/cjcu20220703 Abstract （1567）   HTML （113）    PDF（pc） （9332KB）（983）       Knowledge map    Save Global challenges have promoted the rapid development of rechargeable lithium battery technology. Solid-state electrolytes are less flammable than liquid electrolytes. If the ion transport behavior in solid electrolytes is well understood， the lithium dynamic stability and rate performance of solid state batteries can be accurately regulated. With the rapid development of calculation technology， atomic scale simulation technology has become an important method to understand the ion transport of materials. To solve the above problems， this review firstly summarizes the common diffusion mechanisms in solid materials. Then the transport mechanism of lithium ions in solid electrolytes is introduced， and the important factors（crystal structure， electronic structure， external factors， grain boundaries） affecting the transport of lithium ions in solid electrolytes are emphatically included. Finally， the transport mechanism of lithium ion in solid electrolytes is summarized and prospected. Table and Figures | Reference | Related Articles | Metrics

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Research Progress and Mechanism of cGAS-STING Pathway in Tumor Immunotherapy WANG Shihao, SHI Wanrui, LIU Yi, ZHANG Hao Chem. J. Chinese Universities    2025, 46 (1): 20240241-.   DOI: 10.7503/cjcu20240241 Abstract （1553）   HTML （22）    PDF（pc） （9509KB）（349）       Knowledge map    Save The cyclic guanosine monophosphate-adenosine monophosphate（GMP-AMP） synthase（cGAS protein）- stimulator of interferon genes（STING protein)（cGAS-STING） signaling pathway is a crucial pathway for recognizing abnormal DNA in the cytoplasm and activating the innate immune response system. After recognizing abnormal DNA in the cytoplasm， cGAS protein can catalyze the synthesis of cyclic guanosine diphosphate adenosine（cyclic GMP-AMP， cGAMP） from adenosine triphosphate（ATP） and guanosine triphosphate（GTP）. cGAMP， as a second messenger， activates the stimulator of interferon gene（STING protein）， promoting the release of type I interferons and thus initiating a series of immune responses. The cGAS-STING pathway can regulate tumor metastasis and growth， participate in anti-tumor innate immune responses， and exploring the mechanism of action of the cGAS-STING pathway is of great significance in tumor immunotherapy. This review introduces the mechanism of action of the cGAS-STING pathway and summarizes various strategies currently used to activate the cGAS-STING pathway in anti-tumor immunotherapy. Table and Figures | Reference | Related Articles | Metrics

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Molecular Dynamics Simulation of Ion Adsorption at Water/Graphene Interface： Force Field Parameter Optimization and Adsorption Mechanism LIAO Shouwei, LIU Yanchang, SHI Zenan, ZHAO Daohui, WEI Yanying, LI Libo Chem. J. Chinese Universities    2023, 44 (10): 20230155-.   DOI: 10.7503/cjcu20230155 Abstract （1546）   HTML （52）    PDF（pc） （5971KB）（552）       Knowledge map    Save The researches of salt solution confined in two-dimensional nanochannels are of great significance in a wide range of fields such as ion transport and sieving， supercapacitor， etc.， and molecular dynamics（MD） simulations in these research have become an important tool. However， it is difficult for common MD force fields（FFs） to accurately describe the ion-π interactions between two-dimensional materials（e.g.， graphene） and ions. In addition， the role of solvent effects on regulating ion adsorption on the solution/material interface also lacks in-depth studies. In this work， we have developed the FF parameters for the interactions between Li+， Na+， K+， Mg2+， Ca2+， Cl‒ ions and graphene based on the potentials of mean force（PMFs）. The ion adsorption free energies on the graphene surface（in solution） simulated using the as-developed FF coincided with the quantum chemical calculations， which verified the accuracy of the as-developed FF. Furthermore， significant correlations were found between the ion hydration radius， the inflection point of the hydration number as the ion approaches the graphene， the position of the PMFwat（the contributions of water to the PMFs of ion adsorption on graphene surface） minima and the position of the water layer on the graphene surface， elucidating the effects of ion dehydration and the water layers on graphene surface on PMFwat. In addition， the salt solution（concentration of 1 mol/L）/graphene interface systems were simulated. For the above systems， ions simulated by common MD FFs hardly absorb on graphene surface， which indicates that ion-π interactions are indispensable for accurately simulating the salt solution-graphene systems. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Progress on the Recognition， Complex Structure and Intracellular Detection of Nucleic Acid G-quadruplex LIU Wenting, LIU Liuyi, ZHU Bochen, MAO Zongwan Chem. J. Chinese Universities    2023, 44 (3): 20220419-.   DOI: 10.7503/cjcu20220419 Abstract （1457）   HTML （64）    PDF（pc） （7527KB）（1268）       Knowledge map    Save DNA or RNA guanine-rich sequences can form non-canonical secondary structures known as G-quadruplexes. The structures of G-quadruplex are rich and diverse， and they exist dynamically in organisms. G-quadruplex is involved in key genomic functions such as transcription， replication， genomic stability and epigenetic regulation and is closely related to cancer biology. The studies on the structural and functional mechanisms of G-quadruplex have promoted G-quadruplex-targeted tumor intervention and treatment. This paper reviews the specific recognition， cell detection and biological functional regulation of G-quadruplex， summarizes the research progress in designing small molecules recognizing and targeting of G-quadruplex and their complex structures. The possibility of G-quadruplex-targeted intervention and disease treatment is discussed. Finally， the challenges and opportunities in the future research of G-quadruplex field are prospected. Table and Figures | Reference | Related Articles | Metrics

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Cover and Content of Chemical Journal of Chinese Universities Vol.47 No.1(2026) Chem. J. Chinese Universities    2026, 47 (1): 1-6.   Abstract （1432）      PDF（pc） （26559KB）（144）       Knowledge map    Save Related Articles | Metrics

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Preparation of PLGA-Curcumin Nanoparticles and Evaluation of Its Anti-inflammatory Properties in vitro LI Zhen, HAO Kai, HE Chaoliang, TIAN Huayu Chem. J. Chinese Universities    2023, 44 (10): 20230154-.   DOI: 10.7503/cjcu20230154 Abstract （1415）   HTML （35）    PDF（pc） （5239KB）（399）       Knowledge map    Save In this paper， we used polyvinyl alcohol（PVA） aqueous solution as the aqueous phase， poly lactic- co-glycolic acid（PLGA） and curcumin（Cur） dichloromethane solution as the oil phase to prepare curcumin-encapsulated PLGA nanoparticles（PLGA@Cur NPs） by a water-in-oil-in-water double emulsion method. PLGA@Cur improved the dispersion of curcumin and enhanced its antioxidant and anti-inflammatory properties. The results of dynamic light scattering（DLS） and scanning electron microscopy（SEM） showed that PLGA@Cur NPs was homogeneous and spherical with an average size of （340.1±14.9） nm， a polydispersity index（PDI） of （0.22±0.01） and a potential of （-20.20±4.17） mV， and had good stability. The drug loading and encapsulation rate of Cur in PLGA@Cur NPs were determined by high performance liquid chromatography（HPLC）， and the encapsulation rate was 15.1% and the drug loading rate was 34.9%. The results at the cellular level showed that PLGA@Cur NPs had good biocompatibility and could scavenge a variety of reactive oxygen species（ROS）， and effectively reduced the level of pro-inflammatory cytokines secreted by RAW 264.7 macrophages and alleviate inflammation at the cellular level. Table and Figures | Reference | Related Articles | Metrics

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MOFs-based Microfluidic Chips for Real-time Online Determination of Multiple Heavy Metal Ions CHEN Xiaoping, WANG Xutan, LIU Ning, WANG Qingxiang, NI Jiancong, YANG Weiqiang, LIN Zhenyu Chem. J. Chinese Universities    2024, 45 (2): 20230395-.   DOI: 10.7503/cjcu20230395 Abstract （1392）   HTML （58）    PDF（pc） （5671KB）（1881）       Knowledge map    Save This study combines the accumulation effects of rich microporous ZIF-8 metal-organic framework（MOF） and the electrochemical technology for the metal ions， and the controllable ability of microfluidic devices for the flowing of solution， to construct a new type of sensor to achieve high-throughput， real-time and rapid detection of multiple metal ion contaminations in the environment. The developed ZIF-8-Nafion/ITO-based microfluidic electrochemical sensors have a good linear relationship for Cd2+， Pb2+ and Hg2+ ions in the concentration range of 0.1—100 μmol/L with the detection limit of 0.055， 0.0025 and 0.0016 μmol/L， respectively（S/N=3）. The microfluidic chips require less sample volume which reduces energy consumption； at the same time， the microfluidic devices made up of polydimethylsiloxane are also expected to realize the function of flexible electrodes， which is important for the integrated and automatic detection of biological and environmental samples using portable and flexible electro- chemical devices. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Study on the Polymorphism of Linagliptin LIU Qi, LIU Moyi, DONG Siyu, WANG Xuezhong, HE Yunliang Chem. J. Chinese Universities    2024, 45 (1): 20230400-.   DOI: 10.7503/cjcu20230400 Abstract （1326）   HTML （30）    PDF（pc） （3824KB）（934）       Knowledge map    Save In this paper， the complicated polymorphism of linagliptin was investigated along with conformational changes in the lattice. Three crystal structures including form A were obtained for the first time by the growth of single crystals and X-ray single-crystal diffraction analysis. The structure and molecular conformation of each crystal were analyzed in combination with two crystal structures reported in the literature. Two crystal forms， form A and form F， are found among the five crystals. Form F can exist as a variety of channel solvates， with lattice parameters varying slightly with the included solvent. There is a high energy barrier between the conformers in form A lattice and those in form F， which probably accounts for the difficult conversion from form F to form A. The molecular conformations are not identical in the varieties of form F， and their powder X-ray raditional diffraction（PXRD） patterns are also distinctly different. Finally， the conversion between form A and form F was revealed by common methods， such as suspension conversion and thermal analysis. Table and Figures | Reference | Related Articles | Metrics

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Structure and Photoluminescence Origin of Carbon Dots TAO Songyuan, XIA Chunlei, YANG Bai Chem. J. Chinese Universities    2023, 44 (10): 20230241-.   DOI: 10.7503/cjcu20230241 Abstract （1220）   HTML （72）    PDF（pc） （18972KB）（375）       Knowledge map    Save As environmentally friendly and high-performance nanomaterials， carbon dots（CDs） have shown good application potential in many cutting-edge fields， e.g. optoelectronic devices， biological diagnosis and treatment， and energy catalysis， which has attracted much attention in recent years. Due to the significant differences in raw materials and synthesis methods， CDs always show complex optical properties. Based on the previous research work of our research group and the analysis of the particle growth process， this article introduces the main photoluminescence（PL） mechanisms of CDs， including the carbon core state of conjugated π-domain， surface-edge state， organic fluorophores-like molecular state， and crosslink enhanced emission effect. This paper comprehensively reviewed controversial scientific issues on particle structure and PL origin in the field of CDs， and prospected the future trends. Table and Figures | Reference | Related Articles | Metrics

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Rapid Grafting of Phenylboronic Acid with Hydroxypropyl Chitosan Mediated by HATU LI Aoqi, HU Chuanzhi, SHI Han, DENG Mingyu, XIAO Bo, JIANG Bo Chem. J. Chinese Universities    2023, 44 (6): 20220698-.   DOI: 10.7503/cjcu20220698 Abstract （1215）   HTML （48）    PDF（pc） （1100KB）（5195）       Knowledge map    Save Phenylboronic acid（PBA） can form reversible covalent bonds with cis-1，2-diol or 1，3-diol in an aqueous solution， which makes it useful as the glucose-responsive units or dynamic cross-linking groups in nano/hydrogels. In this paper， PBA was efficiently grafted on hydroxypropyl chitosan（HPCS） by employing 2-（7-azabenzotriazol-1-yl）- N，N，N'，N'-tetramethyluronium hexafluorophosphate（HATU） as a coupling reagent in dimethyl sulfoxide（DMSO）. The resulting carboxyphenylboronic acid-grafted hydroxypropyl chitosan（CPBA-HPCS） was soluble when pH>8.5， and the structure was characterized and confirmed by Fourier-transform infrared spectroscopy（FTIR） and nuclear magnetic resonance（NMR）. In addition， the kinetics of the reaction were studied and a series of CPBA-HPCS with different substitution degrees（up to 0.78） was prepared. This novel chitosan derivative has good application prospects in the preparation of smart hydrogels and drug carriers. Table and Figures | Reference | Related Articles | Metrics

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Recent Advances in Green C-N Coupling for Urea Synthesis ZHANG Xiaoran, ZHENG Jianyun, LYU Yanhong, WANG Shuangyin Chem. J. Chinese Universities    2023, 44 (5): 20220717-.   DOI: 10.7503/cjcu20220717 Abstract （1213）   HTML （55）    PDF（pc） （6788KB）（541）       Knowledge map    Save The industrial synthesis of chemicals usually operates under harsh conditions with high energy consumption， aggravating energy crisis and environmental concerns. Driven by renewable electricity or/and solar energy， the energy barrier of the reaction could be reduced to achieve the efficient and green synthesis of chemicals under milder conditions. As the main small molecules， carbon dioxide and nitrogen can be used to synthesize various carbon and nitrogen-containing fuels through electrocatalysis， which can alleviate environmental problems while reducing the pressure of energy depletion and achieve the purpose of efficient energy storage. This paper briefly summarizes the recent advances in electrochemical conversion of N2 and CO2， focusing on the improvement of reaction conditions， the adjustment of reaction route， and the investigation of catalytic mechanism. The current challenges and future development for electrocatalytic coupling of C-N are prospected. This mini-review provides a useful guidance for further developing electrochemical conversion of N2 and CO2. Table and Figures | Reference | Related Articles | Metrics

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Recent Progress of Hard Carbon Anode Materials for Sodium Ion Batteries YANG Cuiyun, YANG Chenghao Chem. J. Chinese Universities    2023, 44 (5): 20220728-.   DOI: 10.7503/cjcu20220728 Abstract （1208）   HTML （48）    PDF（pc） （16813KB）（466）       Knowledge map    Save Sodium ion batteries（SIBs） have been regarded as the compatible and complementary to lithium ion batteries for energy storage due to abundant sodium resources， low cost and excellent low temperature performance. Therefore， accelerating the commercialization of SIBs can reduce the risk of lithium supply to ensure the long-term stable development of the new energy industry. As the host material for intercalation of large-radius sodium ions， the related design and development requirements of anode material are more demanding. Currently， hard carbon（HC） has been considered one of the most suitable anode materials for sodium ion batteries and large-scale commercialization. This paper reviews the bottleneck of high performance SIBs development， the materials characteristics， sodium storage mechanism and functionalized design strategies of hard carbon materials. Moreover， the advantages and disadvantages of various optimization strategies are discussed. Finally， future developments and challenges relating to ideal HCs are also proposed on the basis of recent progress. Table and Figures | Reference | Related Articles | Metrics

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Recent Progress in Non-fused Ring Small-molecule Acceptor Materials SUN Heng, ZHANG Pengyu, ZHANG Yingnan, ZHAN Chuanlang Chem. J. Chinese Universities    2023, 44 (7): 20230076-.   DOI: 10.7503/cjcu20230076 Abstract （1200）   HTML （37）    PDF（pc） （10367KB）（653）       Knowledge map    Save The invention of non-fullerene acceptors with rigid and fused ring structures has pushed a rapid progress in the field of organic solar cells. The power conversion efficiencies（PCEs） have exceeded 19%. Compared with the fused ring structures， the non-fused ring acceptors have recently received increasing attention due to their relatively simple structures and synthesis. Since 2017， the molecular library of non-fused ring acceptors has extended up to more than 100 molecules and the PCEs have rapidly increased from the initial 4% to the recent 16%. In this review， we classified these molecules into fully non-fused ring acceptors and A-D-C n -D-A type non-fused ring acceptors， according to the non-fused ring backbone structural features. We correlate the molecular structures and the optical， electrochemical and photovoltaic properties from the aspects of non-fused ring backbone structures and side chain engineering. In particular， we focus on that the non-fused ring backbone structures， intramolecular non-covalent interactions and side chain engineering finely tune the materials’ energy levels and bandgaps and photovoltaic performance. We also give suggestions to overcome the factors that limit the increase of solar cell performance. Table and Figures | Reference | Related Articles | Metrics

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Recent Progress on Carbon Dots Preparation and Electrochemical Energy Application WANG Siyang, JING Wen, CHANG Jiangwei, LU Siyu Chem. J. Chinese Universities    2023, 44 (5): 20220733-.   DOI: 10.7503/cjcu20220733 Abstract （1199）   HTML （40）    PDF（pc） （10511KB）（263）       Knowledge map    Save As a typical zero-dimensional carbon material， carbon dots （CDs） with particle size smaller than 10 nm are composed by sp2/ sp3 hybridization of carbon atoms. Owing to their unique physicochemical structures， CDs have many features， such as rich edge sites and accessibility for functional modification， which endow themselves wide applications in electrocatalysis and energy storage/conversion. Based on this， it is of great significance to reveal the formation mechanism of CDs and clarify the structure-property relationship， which is helpful in guiding the synthesis of CDs and then obtain excellent catalytic performance. Therefore， based on the introduction of preparation and regulation strategies of CDs， this paper analyzes the activity origin of CDs-based catalytic materials by combining with theoretical investigations and more importantly， reviews the recent progress of CDs applications in electro- chemistry and discusses the opportunities and challenges for the future development of functional CDs materials. Table and Figures | Reference | Related Articles | Metrics

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Recent Advances in Carbon Dots with Near-infrared Absorption/Emission LIU Yupeng, YANG Junxiang, HAO Yiming, QU Songnan Chem. J. Chinese Universities    2025, 46 (6): 20240070-.   DOI: 10.7503/cjcu20240070 Abstract （1189）   HTML （29）    PDF（pc） （30102KB）（319）       Knowledge map    Save Carbon dots（CDs） are an emerging class of zero-dimensional carbon nano-optical materials that are as promising candidates for various applications. Compared with visible light， near-infrared light has deeper tissue penetration and lower scattering， giving it obvious advantages in fields such as biological imaging. Through the exploration of scientific researchers， the optical band gap of CDs has been continuously regulated and red-shifted from the initial blue-violet light to longer wavelengths. In recent years， CDs with near-infrared absorption/emission have been gradually reported. Based on a series of works by our research group on the near-infrared carbon dots， this review summarizes and reviews the latest progress in preparation strategies and applications of near-infrared carbon dots， and prospectively outlines the future development directions. Table and Figures | Reference | Related Articles | Metrics