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Hydrogel-based Bioinspired Ion Channels： Fabrication and Controllable Ion Transport CHEN Weipeng, KONG Xiangyu, WEN Liping Chem. J. Chinese Universities    2023, 44 (6): 20220772-.   DOI: 10.7503/cjcu20220772 Abstract （1108）   HTML （58）    PDF（pc） （14959KB）（946）       Knowledge map    Save The controllable ion transport is the basis of most physiological activities， such as the transmission of neural signals， the perception of external stimuli， etc. The key to realize the controllable ion transport is the various protein ion channels in life system. Inspiring researchers endeavor to develop artificial ion channels to subtly tune the ion transportation. Among the developed ion channels， hydrogel-based system exhibits the advantages of high ion selectivity and high ion conductance due to its three-dimensional（3D） charged networks induced space charges and 3D interconnection channels. As hydrogel-based ion channels hold the biocompatibility， deformability， and stable ion storage properties， it has been the focus in intelligence ion transport field and shows great potential in ion electronic circuits， medical health， energy conversion and storage， resources， and environment. To summarize the latest development of the hydrogel-based ion channels， we firstly overview on the construction methods of hydrogel-based intelligent ion channels. Thereafter， the ion transport mechanisms in the hydrogel-based ion channels are summarized， and the applications of such ion channels are categorized. At last， we discuss the existed issues and give the perspective on future development of hydrogel-based ion channels. Table and Figures | Reference | Related Articles | Metrics

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Molecular Dynamics Simulation of Ion Adsorption at Water/Graphene Interface： Force Field Parameter Optimization and Adsorption Mechanism LIAO Shouwei, LIU Yanchang, SHI Zenan, ZHAO Daohui, WEI Yanying, LI Libo Chem. J. Chinese Universities    2023, 44 (10): 20230155-.   DOI: 10.7503/cjcu20230155 Abstract （1001）   HTML （35）    PDF（pc） （5971KB）（390）       Knowledge map    Save The researches of salt solution confined in two-dimensional nanochannels are of great significance in a wide range of fields such as ion transport and sieving， supercapacitor， etc.， and molecular dynamics（MD） simulations in these research have become an important tool. However， it is difficult for common MD force fields（FFs） to accurately describe the ion-π interactions between two-dimensional materials（e.g.， graphene） and ions. In addition， the role of solvent effects on regulating ion adsorption on the solution/material interface also lacks in-depth studies. In this work， we have developed the FF parameters for the interactions between Li+， Na+， K+， Mg2+， Ca2+， Cl‒ ions and graphene based on the potentials of mean force（PMFs）. The ion adsorption free energies on the graphene surface（in solution） simulated using the as-developed FF coincided with the quantum chemical calculations， which verified the accuracy of the as-developed FF. Furthermore， significant correlations were found between the ion hydration radius， the inflection point of the hydration number as the ion approaches the graphene， the position of the PMFwat（the contributions of water to the PMFs of ion adsorption on graphene surface） minima and the position of the water layer on the graphene surface， elucidating the effects of ion dehydration and the water layers on graphene surface on PMFwat. In addition， the salt solution（concentration of 1 mol/L）/graphene interface systems were simulated. For the above systems， ions simulated by common MD FFs hardly absorb on graphene surface， which indicates that ion-π interactions are indispensable for accurately simulating the salt solution-graphene systems. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Split Intein： a Versatile Tool for Traceless Peptide Segment Ligation HAN Dongyang, REN Yuxiang, YANG Ziyi, HUANG He, ZHENG Jishen Chem. J. Chinese Universities    2023, 44 (10): 20230188-.   DOI: 10.7503/cjcu20230188 Abstract （992）   HTML （53）    PDF（pc） （5394KB）（1155）       Knowledge map    Save Split intein can efficiently ligate peptide segments via a splicing reaction in a traceless manner and therefore has attracted great attention. Based on the structural characteristics and splicing reaction process of split intein， this paper comprehensively reviewed the recent progresses on the performance optimization and expanded applications of split intein， and revealed its great potential in the field of chemical protein synthesis as an increasingly sophisticated protein engineering technology. Finally， the challenges presented in the split intein- mediated protein trans-splicing and potential solutions in the future research were briefly discussed. Table and Figures | Reference | Related Articles | Metrics

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MOFs-based Microfluidic Chips for Real-time Online Determination of Multiple Heavy Metal Ions CHEN Xiaoping, WANG Xutan, LIU Ning, WANG Qingxiang, NI Jiancong, YANG Weiqiang, LIN Zhenyu Chem. J. Chinese Universities    2024, 45 (2): 20230395-.   DOI: 10.7503/cjcu20230395 Abstract （912）   HTML （49）    PDF（pc） （5671KB）（987）       Knowledge map    Save This study combines the accumulation effects of rich microporous ZIF-8 metal-organic framework（MOF） and the electrochemical technology for the metal ions， and the controllable ability of microfluidic devices for the flowing of solution， to construct a new type of sensor to achieve high-throughput， real-time and rapid detection of multiple metal ion contaminations in the environment. The developed ZIF-8-Nafion/ITO-based microfluidic electrochemical sensors have a good linear relationship for Cd2+， Pb2+ and Hg2+ ions in the concentration range of 0.1—100 μmol/L with the detection limit of 0.055， 0.0025 and 0.0016 μmol/L， respectively（S/N=3）. The microfluidic chips require less sample volume which reduces energy consumption； at the same time， the microfluidic devices made up of polydimethylsiloxane are also expected to realize the function of flexible electrodes， which is important for the integrated and automatic detection of biological and environmental samples using portable and flexible electro- chemical devices. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Preparation of PLGA-Curcumin Nanoparticles and Evaluation of Its Anti-inflammatory Properties in vitro LI Zhen, HAO Kai, HE Chaoliang, TIAN Huayu Chem. J. Chinese Universities    2023, 44 (10): 20230154-.   DOI: 10.7503/cjcu20230154 Abstract （886）   HTML （20）    PDF（pc） （5239KB）（312）       Knowledge map    Save In this paper， we used polyvinyl alcohol（PVA） aqueous solution as the aqueous phase， poly lactic- co-glycolic acid（PLGA） and curcumin（Cur） dichloromethane solution as the oil phase to prepare curcumin-encapsulated PLGA nanoparticles（PLGA@Cur NPs） by a water-in-oil-in-water double emulsion method. PLGA@Cur improved the dispersion of curcumin and enhanced its antioxidant and anti-inflammatory properties. The results of dynamic light scattering（DLS） and scanning electron microscopy（SEM） showed that PLGA@Cur NPs was homogeneous and spherical with an average size of （340.1±14.9） nm， a polydispersity index（PDI） of （0.22±0.01） and a potential of （-20.20±4.17） mV， and had good stability. The drug loading and encapsulation rate of Cur in PLGA@Cur NPs were determined by high performance liquid chromatography（HPLC）， and the encapsulation rate was 15.1% and the drug loading rate was 34.9%. The results at the cellular level showed that PLGA@Cur NPs had good biocompatibility and could scavenge a variety of reactive oxygen species（ROS）， and effectively reduced the level of pro-inflammatory cytokines secreted by RAW 264.7 macrophages and alleviate inflammation at the cellular level. Table and Figures | Reference | Related Articles | Metrics

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Recent Progress in Non-fused Ring Small-molecule Acceptor Materials SUN Heng, ZHANG Pengyu, ZHANG Yingnan, ZHAN Chuanlang Chem. J. Chinese Universities    2023, 44 (7): 20230076-.   DOI: 10.7503/cjcu20230076 Abstract （867）   HTML （33）    PDF（pc） （10367KB）（541）       Knowledge map    Save The invention of non-fullerene acceptors with rigid and fused ring structures has pushed a rapid progress in the field of organic solar cells. The power conversion efficiencies（PCEs） have exceeded 19%. Compared with the fused ring structures， the non-fused ring acceptors have recently received increasing attention due to their relatively simple structures and synthesis. Since 2017， the molecular library of non-fused ring acceptors has extended up to more than 100 molecules and the PCEs have rapidly increased from the initial 4% to the recent 16%. In this review， we classified these molecules into fully non-fused ring acceptors and A-D-C n -D-A type non-fused ring acceptors， according to the non-fused ring backbone structural features. We correlate the molecular structures and the optical， electrochemical and photovoltaic properties from the aspects of non-fused ring backbone structures and side chain engineering. In particular， we focus on that the non-fused ring backbone structures， intramolecular non-covalent interactions and side chain engineering finely tune the materials’ energy levels and bandgaps and photovoltaic performance. We also give suggestions to overcome the factors that limit the increase of solar cell performance. Table and Figures | Reference | Related Articles | Metrics

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Research Progress and Mechanism of cGAS-STING Pathway in Tumor Immunotherapy WANG Shihao, SHI Wanrui, LIU Yi, ZHANG Hao Chem. J. Chinese Universities    2025, 46 (1): 20240241-.   DOI: 10.7503/cjcu20240241 Abstract （846）   HTML （8）    PDF（pc） （9509KB）（247）       Knowledge map    Save The cyclic guanosine monophosphate-adenosine monophosphate（GMP-AMP） synthase（cGAS protein）- stimulator of interferon genes（STING protein)（cGAS-STING） signaling pathway is a crucial pathway for recognizing abnormal DNA in the cytoplasm and activating the innate immune response system. After recognizing abnormal DNA in the cytoplasm， cGAS protein can catalyze the synthesis of cyclic guanosine diphosphate adenosine（cyclic GMP-AMP， cGAMP） from adenosine triphosphate（ATP） and guanosine triphosphate（GTP）. cGAMP， as a second messenger， activates the stimulator of interferon gene（STING protein）， promoting the release of type I interferons and thus initiating a series of immune responses. The cGAS-STING pathway can regulate tumor metastasis and growth， participate in anti-tumor innate immune responses， and exploring the mechanism of action of the cGAS-STING pathway is of great significance in tumor immunotherapy. This review introduces the mechanism of action of the cGAS-STING pathway and summarizes various strategies currently used to activate the cGAS-STING pathway in anti-tumor immunotherapy. Table and Figures | Reference | Related Articles | Metrics

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Rapid Grafting of Phenylboronic Acid with Hydroxypropyl Chitosan Mediated by HATU LI Aoqi, HU Chuanzhi, SHI Han, DENG Mingyu, XIAO Bo, JIANG Bo Chem. J. Chinese Universities    2023, 44 (6): 20220698-.   DOI: 10.7503/cjcu20220698 Abstract （810）   HTML （21）    PDF（pc） （1100KB）（1441）       Knowledge map    Save Phenylboronic acid（PBA） can form reversible covalent bonds with cis-1，2-diol or 1，3-diol in an aqueous solution， which makes it useful as the glucose-responsive units or dynamic cross-linking groups in nano/hydrogels. In this paper， PBA was efficiently grafted on hydroxypropyl chitosan（HPCS） by employing 2-（7-azabenzotriazol-1-yl）- N，N，N'，N'-tetramethyluronium hexafluorophosphate（HATU） as a coupling reagent in dimethyl sulfoxide（DMSO）. The resulting carboxyphenylboronic acid-grafted hydroxypropyl chitosan（CPBA-HPCS） was soluble when pH>8.5， and the structure was characterized and confirmed by Fourier-transform infrared spectroscopy（FTIR） and nuclear magnetic resonance（NMR）. In addition， the kinetics of the reaction were studied and a series of CPBA-HPCS with different substitution degrees（up to 0.78） was prepared. This novel chitosan derivative has good application prospects in the preparation of smart hydrogels and drug carriers. Table and Figures | Reference | Related Articles | Metrics

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Cross-linking PEDOT∶F Hole-transporting Layer to Enhance Photovoltaic Performance of Flexible Organic Solar Cells WEI Wanxia, ZHOU Xianmin, DONG Xinyun, LIU Tiefeng, XIE Cong, CHENG Jingyu, CHEN Jianping, LU Xin, FENG Kai, ZHOU Yinhua Chem. J. Chinese Universities    2023, 44 (7): 20230069-.   DOI: 10.7503/cjcu20230069 Abstract （788）   HTML （36）    PDF（pc） （1855KB）（291）       Knowledge map    Save Silver nanowires（AgNWs） are important printable top electrodes in flexible organic solar cells（OSCs）. However， when fabricating AgNWs from ethanol solution， it could cause damage on the hole-transporting layer below due to washing out. In this work， we propose a cross-linking strategy on the hole-transporting layer of poly（3，4-ethylenedioxythiophene）∶perfluorinated sulfonic acid ionomer（PEDOT∶F） to improve its alcohol resistance. By introducing a cross-linker of poly（ethylene glycol）diglycidyl ether（PEGDE）， PEDOT：F was successfully cross-linked. Based on the cross-linked PEDOT∶F hole-transporting layer， small-area flexible OSCs（0.041 cm2） showed power conversion efficiency of 14.86%. Flexible organic solar module（21.18 cm2） was then fabricated and an efficiency of 12.38% was achieved. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Effect of Water Flooding at Different Positions of Cathode Side on the Performance of Proton Exchange Membrane Fuel Cell CHEN Yafeng, ZENG Liuli, GUO Wei Chem. J. Chinese Universities    2023, 44 (6): 20230003-.   DOI: 10.7503/cjcu20230003 Abstract （768）   HTML （9）    PDF（pc） （1452KB）（556）       Knowledge map    Save The discharge of the water generated by the cathode of the fuel cell is mainly related to the catalytic layer， carbon paper， microporous layer and flow channel. The accumulation of generated water in these four parts will cause flooding. However， it is difficult to distinguish which part of the water flooding is caused by the accumulation during the operation of the fuel cell. In this paper， hydrophilic and hydrophobic treatment was carried out on different parts of the cathode side（catalytic layer， carbon paper， microporous layer， flow passage） to obtain local flooding in different parts. Then， the flooding situation of fuel cells was analyzed under different stoich， humidity， back pressure and other conditions. The test results show that with the decrease of stoich， the performance of the battery without hydrophobic treatment in carbon paper is the most serious decline， and the impedance arc radius of the battery is increased by 1.5 times. When the cathode was humidified at 10%， the performance of the cells without hydrophobic treatment in carbon paper and flow passage was poor， and the impedance are radius of the two cells was 50% larger than that of the cathode humidified at 60%； when the cathode is 100% humidified， the performance of the cell without hydrophobic treatment in carbon paper is the best， while that of the cell without hydrophobic treatment in the catalytic layer is the worst， and the impedance arc radius of the cell without hydrophobic treatment in the catalytic layer is twice as large as that of the cell with 10% humidification. With the decrease of back pressure， the performance of the cell without hydrophobic treatment of carbon paper decreased the most seriously， and the impedance arc radius of the cell under high back pressure was 50% smaller than that under low back compression. Table and Figures | Reference | Related Articles | Metrics

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Study on the Polymorphism of Linagliptin LIU Qi, LIU Moyi, DONG Siyu, WANG Xuezhong, HE Yunliang Chem. J. Chinese Universities    2024, 45 (1): 20230400-.   DOI: 10.7503/cjcu20230400 Abstract （767）   HTML （24）    PDF（pc） （3824KB）（602）       Knowledge map    Save In this paper， the complicated polymorphism of linagliptin was investigated along with conformational changes in the lattice. Three crystal structures including form A were obtained for the first time by the growth of single crystals and X-ray single-crystal diffraction analysis. The structure and molecular conformation of each crystal were analyzed in combination with two crystal structures reported in the literature. Two crystal forms， form A and form F， are found among the five crystals. Form F can exist as a variety of channel solvates， with lattice parameters varying slightly with the included solvent. There is a high energy barrier between the conformers in form A lattice and those in form F， which probably accounts for the difficult conversion from form F to form A. The molecular conformations are not identical in the varieties of form F， and their powder X-ray raditional diffraction（PXRD） patterns are also distinctly different. Finally， the conversion between form A and form F was revealed by common methods， such as suspension conversion and thermal analysis. Table and Figures | Reference | Related Articles | Metrics

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Structure and Photoluminescence Origin of Carbon Dots TAO Songyuan, XIA Chunlei, YANG Bai Chem. J. Chinese Universities    2023, 44 (10): 20230241-.   DOI: 10.7503/cjcu20230241 Abstract （726）   HTML （60）    PDF（pc） （18972KB）（290）       Knowledge map    Save As environmentally friendly and high-performance nanomaterials， carbon dots（CDs） have shown good application potential in many cutting-edge fields， e.g. optoelectronic devices， biological diagnosis and treatment， and energy catalysis， which has attracted much attention in recent years. Due to the significant differences in raw materials and synthesis methods， CDs always show complex optical properties. Based on the previous research work of our research group and the analysis of the particle growth process， this article introduces the main photoluminescence（PL） mechanisms of CDs， including the carbon core state of conjugated π-domain， surface-edge state， organic fluorophores-like molecular state， and crosslink enhanced emission effect. This paper comprehensively reviewed controversial scientific issues on particle structure and PL origin in the field of CDs， and prospected the future trends. Table and Figures | Reference | Related Articles | Metrics

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Advantages and Research Progress of Metal-organic Framework in Supercapacitors LU Chunyu, JING Yuan, WEI Xiaofei, YAO Shiwei, WANG Zhifei, WANG Shubin, DAI Fangna Chem. J. Chinese Universities    2024, 45 (2): 20230450-.   DOI: 10.7503/cjcu20230450 Abstract （694）   HTML （49）    PDF（pc） （24330KB）（393）       Knowledge map    Save Metal-organic framework（MOF） plays an important role in gas separation， energy storage， catalysis and other fields due to its excellent surface area， numerous active sites， adjustable pore size range and flexible framework structure. In recent years， the use of MOF materials with high surface area， permanent pores and inherent redox active sites as electrode materials for supercapacitors has attracted close attention from researchers. This paper starts with the application research of MOF in the field of supercapacitors， introduces the effects of their properties and structures on the electrochemical properties of supercapacitors emphatically， and elaborates the research progress of MOF property regulation and structure design. First of all， the conductivity of MOF is a key performance that affects the energy density and power density of supercapacitors， and the special structure of the material directly affects the conductivity. Secondly， the abundant active sites and adjustable pore size of MOF create conditions for its improvement of electrical conductivity. In addition， the structural stability of MOF is closely related to the cycling performance of supercapacitors. The construction of stable structure is an important prerequisite for enhancing the cycling performance of supercapacitors. Finally， the future research of MOF in the field of supercapacitors is prospected. The structure regulation is still an important research direction in this field. Table and Figures | Reference | Related Articles | Metrics

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Untargeted Lipidomics Reveals Lipid Metabolism Dysfunction During Macrophage Foaming WANG Zengyu, LIU Baohong, QIAO Liang, LIN Ling Chem. J. Chinese Universities    2024, 45 (11): 20240053-.   DOI: 10.7503/cjcu20240053 Abstract （672）   HTML （22）    PDF（pc） （6346KB）（143）       Knowledge map    Save Atherosclerosis is a multifactorial chronic complex disease characterized by the accumulation of lipids， inflammatory responses， and ultimately fibrous plaque formation within arterial walls. Plaque formation begins with the abnormal accumulation of lipids engulfed by macrophages within arterial walls， forming so-called foam cells. Despite the pivotal role of foam cell formation in the pathophysiological remodeling process of blood vessels， in-depth research into lipid metabolism disturbances during macrophage foam cell formation is still relatively lacking. In this study， we constructed and optimized a lipidomics analysis workflow， applying it to analyzing metabolic reprogramming during macrophage foam cell formation. A total of 645 lipid molecules belonging to 16 lipid subclasses were identified. Principal component analysis， time-series pattern analysis， and volcano plot analysis revealed significant differences in lipid levels at different stages of foam cell formation. As incubation time with oxidized low-density lipoprotein increased， the degree of lipid metabolism dysfunction in foam cells increased. Triglycerides， hemolytic phospholipids， and ether phospholipids were upregulated， while phosphatidylserine was downregulated. The significant accumulation of triglycerides enhanced the inflammatory response of macrophages， promoting foam cell formation by further engulfing oxidized low-density lipoprotein. Meanwhile， the synthesis of phosphatidylserine and hemolytic phosphatidylcholine increased significantly in the late stages of foam cell formation， indicating a positive correlation between foam cell formation and cell apoptosis. These lipid molecules may serve as signaling molecules to attract macrophages for the clearance of apoptotic cells. This study not only reveals the significant upregulation of inflammatory responses during foam cell formation but also elucidates the close connection between lipid metabolism disturbances and cell apoptosis signaling. Table and Figures | Reference | Related Articles | Metrics

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Progress on the Efficiency Regulation of Organic Solar Cells by Volatile Solid Additives SONG Xin, GAO Shenzheng, XU Shanlei, XU Hao, ZHOU Xinjie, ZHU Mengbing, HAO Rulin, ZHU Weiguo Chem. J. Chinese Universities    2023, 44 (9): 20230151-.   DOI: 10.7503/cjcu20230151 Abstract （668）   HTML （18）    PDF（pc） （18507KB）（275）       Knowledge map    Save Bulk heterojunction（BHJ） organic solar cells（OSCs） are considered a promising photovoltaic technology due to their solution-processability， eco-friendliness， non-toxicity， and flexibility. The nanoscale morphology of the active layer is a key factor that determines device performance and stability. Researchers have developed various morphology optimization methods， such as thermal annealing， solvent annealing， and solvent additives. However， these treatment methods are incompatible with large-area printing processes and may compromise the internal morphology and device performance stability. Consequently， it is essential to screen a simple yet efficient approach for morphology control in OSC area. In recent years， volatile solid additives have emerged as a feasible direction to improve the energy conversion efficiency（PCE） and stability of OSCs due to their unique molecular properties， which can form strong interaction forces with donor/acceptor molecules. This article systematically summarized the research status of non-halogenated and halogenated volatile solid additives in regulating the morphology and photovoltaic performance of OSCs. We deeply discussed the different mechanisms of optimizing active layer morphology by volatile solid additives， including molecular adsorption energy， interaction between donor and acceptor， crystal nucleation， and growth. Finally， this article analyzed the challenges and future development trends of volatile solid additive. Table and Figures | Reference | Related Articles | Metrics

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Progress in the Construction of Metal Oxide Heterojunctions and Their Application in Photocatalytic CO2 Reduction LI Mengdie, WANG Zumin, QI Jian, YU Ranbo Chem. J. Chinese Universities    2023, 44 (10): 20230196-.   DOI: 10.7503/cjcu20230196 Abstract （667）   HTML （33）    PDF（pc） （15466KB）（267）       Knowledge map    Save China has put forward the strategic goals of “carbon emissions peak” in 2030 and “carbon neutrality” in 2060. It is of great significance to convert CO2 into high-value-added chemical products and liquid fuels， which can reduce the dependence on coal， oil and other traditional resources while achieving carbon emission reduction. Photocatalytic CO2 reduction is a very important way， and the design and preparation of efficient photocatalysts for CO2 reduction are the key. Well-defined heterojunction structures between metals and semiconductors or semi- conductors with matching electronic band structures can effectively promote charge transfer and inhibit the recombination of photogenerated electrons and holes， thus improving the photocatalytic performance. This review focuses on the recent progress of oxide-based heterostructures for photocatalytic CO2 reduction， and systematically summarizes the types and components of the formation of heterostructures， and expounds the internal mechanism of improving the performance of CO2 photocatalysis. Furthermore， the direction of research in this field is also prospected. Table and Figures | Reference | Related Articles | Metrics

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Understanding the Water Structures in Deep Eutectic Solvents by Near-infrared Spectroscopy WANG Yan, CAI Wengsheng, SHAO Xueguang Chem. J. Chinese Universities    2023, 44 (6): 20230017-.   DOI: 10.7503/cjcu20230017 Abstract （657）   HTML （20）    PDF（pc） （2122KB）（796）       Knowledge map    Save The hydrogen bond network structure of choline chloride/urea deep eutectic solvents（DESs）-water mixtures was studied in the range of 5%—95% water content by near infrared spectroscopy. Through the analysis of the near-infrared spectra after choline chloride and urea mixing， the spectral feature of the interaction between urea —NH group and choline chloride Cl- was found， indicating that the formation of NH···Cl- was the reason for the decrease of DESs melting point. Through the near-infrared spectrum analysis of DESs-water mixtures with different water contents， the spectral information of the interaction between water molecules and between water molecules and the —NH and C=O groups in urea was found. Water mainly exists in three kinds of structures， including the bulk water， the hydrated water with urea C=O and the bridge water connect —NH groups. The bulk water destroyed NH···Cl- in DESs， reducing the stability of the system， while the bridge water between urea —NH molecules and the hydrated water with urea C=O increase the stability of the system. The relative content of the three water structures in DESs is related to the water content. The water content of 40%—80% can not only effectively reduce the viscosity of the system， but also maintain the properties of DESs. Table and Figures | Reference | Related Articles | Metrics

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Construction and Application of Polylysine Peptide Modified Gelatin Multifunctional Hydrogel JIANG Yunjing, HUANG Tongdai, CAO Yuyu, BAI Rongxian, WU Jie, WANG Zuxi, SUN Hongmei Chem. J. Chinese Universities    2024, 45 (1): 20230312-.   DOI: 10.7503/cjcu20230312 Abstract （647）   HTML （32）    PDF（pc） （7288KB）（1140）       Knowledge map    Save The ε-polylysine（EPL） antibacterial peptide was grafted onto gelatin to synthesize EPL-modified gelatin（GEL-E）， afterwards， a multifunctional hydrogel， GEL-E/CMC/OCS hydrogel， with injectable， self-healing and antibacterial properties was prepared using GEL-E， carboxymethyl chitosan（CMC） and chondroitin oxysulfate（OCS）.The experimental results showed that the hydrogel prepared has high energy storage modulus， elastic deformation， self-healing， injectable and antibacterial properties. Dipotassium glycyrrhizinate（DG） was loaded into hydrogel， which endowed the hydrogel with anti-inflammatory properties and wound healing ability. The results showed that the drug release rate could reach 100%. Meanwhile， the cell compatibility and the ability of promoting cell migration were evaluated， the results showed that the hydrogels presented very low cytotoxicity and could promote cell migration. All the above results indicated that the GEL-E/CMC/OCS hydrogel has good mechanical properties， biocompatibility and ability to promote cell migration， and has broad application prospects in the field of promoting wound healing. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Visualization of Protein-specific Glycosylation and Photodynamic Therapy via an Enzyme-free Amplification Strategy of Catalytic Hairpin Assembly and Hybridization Chain Reaction LI Ting, XING Simin, LIU Yang Chem. J. Chinese Universities    2023, 44 (8): 20230140-.   DOI: 10.7503/cjcu20230140 Abstract （647）   HTML （19）    PDF（pc） （5050KB）（285）       Knowledge map    Save Herein， a highly sensitive， enzyme-free signal amplification strategy based on the proximity-induced catalytic hairpin assembly and hybridization chain reaction（CHA-HCR） was developed for protein-specific glycosy-lation fluorescence imaging of cancer cells in situ and highly efficient photodynamic therapy. Two DNA probes were designed for the specific labeling of target proteins and glycans， respectively， where the protein probe（PP） identified the MUC1 protein by aptamer and the glycan probe（GP） specifically bound to sialic acid via bioorthogonal reaction. Due to the proximity effect， the CHA initiation sequence in the PP hybridized with the adjacent GPs and triggered a subsequent CHA-HCR cascade reaction. An extended double-stranded DNA strand with multiple fluorescent molecules or photosensitizers formed on specific glycosylation of the target protein， which provided a universal avenue for the multiple glycosylation imaging on the cancer cell surface with high sensitivity and a valuable way for photodynamic therapy with enhanced cytotoxic effect by targeting the specific glycoproteins. This strategy supplies the reference for uncovering the mechanism of glycosylation， screening glycan-related biomarkers and developing targeted therapies. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Enhancement of Solubility， Stability and Permeation of Skin-care Ingredients by Amphiphilic Sulfonated Calix［8］arene YU Hongmei, LI Shihui, TIAN Hanwen, LIN Yilin, ZHANG Shuxin, GENG Wenchao, LI Huabin, WANG Honglei, LIU Juan, GUO Dongsheng Chem. J. Chinese Universities    2023, 44 (10): 20230143-.   DOI: 10.7503/cjcu20230143 Abstract （627）   HTML （16）    PDF（pc） （1181KB）（351）       Knowledge map    Save The sulfonated calix［8］arene modified with dodecyl at the lower-rim（SC8A-12C） was synthesized to improve the solubility and stability of vitamin A（Va） in aqueous solution， and promote the percutaneous permeability of Va. Lipophilic Va is almost insoluble in water， SC8A-12C could improve solubility of Va to 1.1 mg/mL and prolong the half-life of Va in aqueous solution from 5 h to 35 h. In vitro transdermal test showed that SC8A-12C increased the transdermal amount of Va by 16.9 times. SC8A-12C also increased the solubility of various skin-care ingredients， such as phenoethylresorcinol， salicylic acid， quercetin and azelaic acid， and increased the transdermal amount of salicylic acid by 3.8 times. SC8A-12C improved the efficacy of Va through improving solubility， stability and skin permeability， and was expected to develop oil-free skin-care products of Va. In view of the SC8A-12C improving solubility of a variety of skin-care ingredients， it is expected to contribute to the development of multi-functional skin-care products. Table and Figures | Reference | Related Articles | Metrics