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Research Progress and Mechanism of cGAS-STING Pathway in Tumor Immunotherapy WANG Shihao, SHI Wanrui, LIU Yi, ZHANG Hao Chem. J. Chinese Universities    2025, 46 (1): 20240241-.   DOI: 10.7503/cjcu20240241 Abstract （1553）   HTML （22）    PDF（pc） （9509KB）（349）       Knowledge map    Save The cyclic guanosine monophosphate-adenosine monophosphate（GMP-AMP） synthase（cGAS protein）- stimulator of interferon genes（STING protein)（cGAS-STING） signaling pathway is a crucial pathway for recognizing abnormal DNA in the cytoplasm and activating the innate immune response system. After recognizing abnormal DNA in the cytoplasm， cGAS protein can catalyze the synthesis of cyclic guanosine diphosphate adenosine（cyclic GMP-AMP， cGAMP） from adenosine triphosphate（ATP） and guanosine triphosphate（GTP）. cGAMP， as a second messenger， activates the stimulator of interferon gene（STING protein）， promoting the release of type I interferons and thus initiating a series of immune responses. The cGAS-STING pathway can regulate tumor metastasis and growth， participate in anti-tumor innate immune responses， and exploring the mechanism of action of the cGAS-STING pathway is of great significance in tumor immunotherapy. This review introduces the mechanism of action of the cGAS-STING pathway and summarizes various strategies currently used to activate the cGAS-STING pathway in anti-tumor immunotherapy. Table and Figures | Reference | Related Articles | Metrics

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Cover and Content of Chemical Journal of Chinese Universities Vol.47 No.1(2026) Chem. J. Chinese Universities    2026, 47 (1): 1-6.   Abstract （1431）      PDF（pc） （26559KB）（144）       Knowledge map    Save Related Articles | Metrics

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Recent Advances in Carbon Dots with Near-infrared Absorption/Emission LIU Yupeng, YANG Junxiang, HAO Yiming, QU Songnan Chem. J. Chinese Universities    2025, 46 (6): 20240070-.   DOI: 10.7503/cjcu20240070 Abstract （1189）   HTML （29）    PDF（pc） （30102KB）（319）       Knowledge map    Save Carbon dots（CDs） are an emerging class of zero-dimensional carbon nano-optical materials that are as promising candidates for various applications. Compared with visible light， near-infrared light has deeper tissue penetration and lower scattering， giving it obvious advantages in fields such as biological imaging. Through the exploration of scientific researchers， the optical band gap of CDs has been continuously regulated and red-shifted from the initial blue-violet light to longer wavelengths. In recent years， CDs with near-infrared absorption/emission have been gradually reported. Based on a series of works by our research group on the near-infrared carbon dots， this review summarizes and reviews the latest progress in preparation strategies and applications of near-infrared carbon dots， and prospectively outlines the future development directions. Table and Figures | Reference | Related Articles | Metrics

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Cover and Content of Chemical Journal of Chinese Universities Vol.46 No.10(2025) Chem. J. Chinese Universities    2025, 46 (10): 1-4.   Abstract （1155）      PDF（pc） （15752KB）（219）       Knowledge map    Save Related Articles | Metrics

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Untargeted Lipidomics Reveals Lipid Metabolism Dysfunction During Macrophage Foaming WANG Zengyu, LIU Baohong, QIAO Liang, LIN Ling Chem. J. Chinese Universities    2024, 45 (11): 20240053-.   DOI: 10.7503/cjcu20240053 Abstract （1143）   HTML （32）    PDF（pc） （6346KB）（225）       Knowledge map    Save Atherosclerosis is a multifactorial chronic complex disease characterized by the accumulation of lipids， inflammatory responses， and ultimately fibrous plaque formation within arterial walls. Plaque formation begins with the abnormal accumulation of lipids engulfed by macrophages within arterial walls， forming so-called foam cells. Despite the pivotal role of foam cell formation in the pathophysiological remodeling process of blood vessels， in-depth research into lipid metabolism disturbances during macrophage foam cell formation is still relatively lacking. In this study， we constructed and optimized a lipidomics analysis workflow， applying it to analyzing metabolic reprogramming during macrophage foam cell formation. A total of 645 lipid molecules belonging to 16 lipid subclasses were identified. Principal component analysis， time-series pattern analysis， and volcano plot analysis revealed significant differences in lipid levels at different stages of foam cell formation. As incubation time with oxidized low-density lipoprotein increased， the degree of lipid metabolism dysfunction in foam cells increased. Triglycerides， hemolytic phospholipids， and ether phospholipids were upregulated， while phosphatidylserine was downregulated. The significant accumulation of triglycerides enhanced the inflammatory response of macrophages， promoting foam cell formation by further engulfing oxidized low-density lipoprotein. Meanwhile， the synthesis of phosphatidylserine and hemolytic phosphatidylcholine increased significantly in the late stages of foam cell formation， indicating a positive correlation between foam cell formation and cell apoptosis. These lipid molecules may serve as signaling molecules to attract macrophages for the clearance of apoptotic cells. This study not only reveals the significant upregulation of inflammatory responses during foam cell formation but also elucidates the close connection between lipid metabolism disturbances and cell apoptosis signaling. Table and Figures | Reference | Related Articles | Metrics

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Research Progress in Exosome Isolation and Proteomics Analysis JIN Ying, ZHANG Junjie, ZHANG Yixin, YUAN Yue, HAN Zhenzhen Chem. J. Chinese Universities    2024, 45 (11): 20240305-.   DOI: 10.7503/cjcu20240305 Abstract （1060）   HTML （44）    PDF（pc） （10724KB）（250）       Knowledge map    Save Exosomes are extracellular vesicles released via the fusion of multivesicular bodies with the cell plasma membrane， containing proteins， lipids， nucleic acids， etc. They transport cargo in the form of extracellular vesicles and participate in various cancer processes such as invasion and metastasis. As emerging targets for liquid biopsy， exosomes play crucial roles in cell communication， signal transduction， and immune response. Mass spectrometry has become an indispensable part of the field of proteomics research， and the proteomic analysis of exosomes is a promising method for discovering potential cancer biomarkers. Recent advances in high‐resolution separations， high‐performance mass spectrometry and comprehensive proteome databases have all contributed to the successful analysis of exosomes from patient samples. Here， this article reviews the isolation methods of exosomes， proteomics analysis techniques， and the application research of proteomics analysis based on exosomes in clinical disease diagnosis. Finally， the challenges faced by exosome isolation and proteomics， as well as the prospects for their clinical applications， are discussed and outlooked. Table and Figures | Reference | Related Articles | Metrics

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Research Progress in Efficient Azide Methods LONG Lei, WEI Wei, LUO Yunjun, LI Xiaoyu Chem. J. Chinese Universities    2024, 45 (5): 20230511-.   DOI: 10.7503/cjcu20230511 Abstract （1054）   HTML （40）    PDF（pc） （2115KB）（309）       Knowledge map    Save Organic azide compounds are a class of multifunctional compounds that are useful precursors for synthesizing a range of therapeutic drugs， bioactive compounds， functional materials， and high-energy compounds. They are widely used in click chemistry and Staudinger reactions. In the past few decades， a large number of synthesis strategies have been developed to prepare structurally diverse organic azides， but not all reactions can be carried out efficiently. As the concept of green chemistry deepens in people’s hearts， traditional azide methods with low safety， universality， and efficiency are gradually being phased out， and the development of new and efficient azide methods is urgent. This review focuses on the efficient synthesis methods for preparing aliphatic azide compounds and azide polymers in recent years. A brief overview of the synthesis of aliphatic azide compounds is provided from the azide strategies of C—C multiple bonds and C—H bonds. The synthesis methods and potential novel synthesis strategies of azide polymers are also discussed， and the future development of azide chemistry is summarized and discussed. Table and Figures | Reference | Related Articles | Metrics

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Research Progress of Electrocatalytic Ammonia Synthesis from Different Nitrogen Sources ZHAO Xiaoguang, WANG Yunlong, YIN Haibo, QU Yakun, SU Haiwei, FANG Wei Chem. J. Chinese Universities    2024, 45 (3): 20230527-.   DOI: 10.7503/cjcu20230527 Abstract （999）   HTML （53）    PDF（pc） （11986KB）（321）       Knowledge map    Save Ammonia is an important raw material for fertilizer production and chemical industry， and is also a good carbon-free energy storage fuel. Compared with the Haber-Bosch method for industrial-scale ammonia synthesis with high energy consumption and low conversion rate， the electrocatalytic ammonia synthesis method has the advantages of green and high efficiency under mild environmental conditions. This article reviews the reaction mechanism of electrocatalytic ammonia synthesis when using nitrogen， nitrate， and nitrogen oxide as different nitrogen sources. Based on the characteristics of different nitrogen sources， the research progress and advantages of each are analyzed. The problems of difficulty in controlling intermediates and reaction paths for nitrate reduction because of the large elemental valence span， complexity of the nitrogen oxide system， difficulty in controlling the hydrogen evolution reaction， and difficulty in dissolving nitrogen in water for activation are discussed， respectively. The solutions are summarized to develop high activity catalysts with different strategies to improve the reaction efficiency and selectivity， to optimize the reaction device to reduce the influence of mass transfer， and to select different electrolyte systems to improve the reaction process. Table and Figures | Reference | Related Articles | Metrics

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Research Progress on Catalytic Oxidative Coupling Reaction of Aniline with Green Oxidants BAN Zhiyong, YANG Caoyu, FENG Qing, YIN Guojun, LI Guodong Chem. J. Chinese Universities    2024, 45 (8): 20240177-.   DOI: 10.7503/cjcu20240177 Abstract （998）   HTML （44）    PDF（pc） （12678KB）（396）       Knowledge map    Save Azobenzene and azoxybenzene compounds have exhibited broad application prospects in the fields of pigments， optical materials， fluorescent probes， and optoelectronic devices. Now many catalysts and oxidants have been developed for the oxidation coupling reaction of aniline to produce azobenzene and azoxybenzene compounds， and among them， developing the green， eco-friendly oxidation systems is still a hot but challenging issue in the current researches. Based on the above， this review summarizes the recent progress in catalyzing the selective oxidation of aniline to generate azobenzene and azoxybenzene compounds with the use of hydrogen peroxide and oxygen as oxidants， and meanwhile， discusses the possible mechanisms of aniline oxidation， mainly including nitrosobenzene intermediate mechanism and radical coupling mechanism. Finally， the potential problems and challenges in the synthesis of catalysts and the catalytic mechanisms have been summarized， and further researches have been prospected. This review will provide an important reference for the development of related fields. Table and Figures | Reference | Related Articles | Metrics

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Preparation of Efficient and Stable Perovskite Solar Cells Based on Amino Acid Derivative Hydrochloride Additives HU Die, SUN Qing, MENG Xiangxin, LING Jinxiang, CHENG Bin, KANG Bonan Chem. J. Chinese Universities    2024, 45 (5): 20240044-.   DOI: 10.7503/cjcu20240044 Abstract （985）   HTML （18）    PDF（pc） （5217KB）（338）       Knowledge map    Save The rapid development of perovskite solar cells（PSCs） has made them one of the most competitive photovoltaic devices in the field of new energy. However， there is still great room for improvement in photoelectric conversion efficiency（PCE） and stability. Here， an amino acid derivative hydrochloride was introduced as an additive in perovskite， D-phenylglycine methyl ester hydrochloride（PGMECl）. PGMECl contains a benzene ring， an ester group， —NH3+ terminal and Cl- ions. The multiple functional groups worked together to react with uncoordinated Pb2+， passivating defects in perovskite. The perovskite grains became denser， surface roughness decreased， and non-radiative recombination of charge carriers was reduced. By adjusting the energy level arrangement， it is more suitable for charge transfer in inverted perovskite solar cells. The results showed that the champion power conversion efficiency（PCE） of PGMECl modification device is 21.04%， which is much higher than that of control devices（17.79%）. The decrease in hysteresis effect also indicates a decrease in ion migration. Under unencapsulated conditions， devices containing PGMECl additives can still maintain a PCE of 70% of the initial efficiency after aging in the dark in air［（40±5）% relative humidity（RH）］ for 1000 h， while the efficiency of the basic device decreases to 50% after 500 h of storage. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Research Progress in Supramolecular Drug Delivery Nanosystems Based on Polyphenols YAN Ziliang, LI Bei, DAI Yunlu Chem. J. Chinese Universities    2025, 46 (1): 20240260-.   DOI: 10.7503/cjcu20240260 Abstract （984）   HTML （27）    PDF（pc） （32893KB）（238）       Knowledge map    Save Supramolecular drug delivery nanoplatforms have attracted much attention due to their diverse functions， controllable drug-releasing property， and unsophisticated techniques for preparation. Polyphenols with phenolic hydroxyl structure have been reported to easily have non-covalent interactions with different drugs， next self- assembling to be supramolecular nanosystems and successfully delivering drugs through desirable administrations. Moreover， polyphenols per se are generally active in defensing tumor， bacteria， oxidative species， inflammation， and protecting cardiac function， which can broaden the biomedical application scope of polyphenol-based delivery systems. In this review， we comprehensively depict the supramolecular interactions involved in the polyphenol-based supramolecular drug delivery systems， and detailedly explain how the interaction force highly affects the drug loading（e.g.， hydrophobic drugs， proteins， and DNA， etc.）. Finally， the controversial issues existing in current polyphenol-based supramolecular nanosystems are summarized and reviewed. This article is expected to shed a new light on the rational designs and fundamental studies of emerging polyphenol-based materials. Table and Figures | Reference | Related Articles | Metrics

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Internal Standard Method-based Surface-enhanced Raman Spectroscopy for Quantitative Analysis BI Yingna, LIU Dingbin Chem. J. Chinese Universities    2025, 46 (2): 20240457-.   DOI: 10.7503/cjcu20240457 Abstract （980）   HTML （47）    PDF（pc） （13761KB）（574）       Knowledge map    Save Surface-enhanced Raman spectroscopy（SERS） is a spectral detection method that has been widely used in the fields of disease diagnosis， drug screening， and biological analysis， etc. It can not only provide rich chemical fingerprint information but also has the advantages of high sensitivity， resistance to photobleaching， and photodegradation. However， due to the poor uniformity of its enhancement matrix structure and the uncertainty of the number of chemical molecules adsorbed， the reproducibility of SERS detection results is poor， which makes it face many challenges in quantitative analysis. The deployment of internal standards could eliminate the external interference factors， thus achieving accurate quantitative analysis. We set out this review with a description of the mechanism of internal-standard methods， followed by introducing their main types. Thereafter， we introduced explanations of the applications of internal-standard probes in environmental analysis， food and drug analysis， and biological analysis. We conclude with an outlook of challenges and future development directions of internal-standard SERS. Table and Figures | Reference | Related Articles | Metrics

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Development and Applications of Ligation-Desulfurization Strategy in Protein Chemical Synthesis XU Ling, YIN Panpan, LU Xianfu, LI Yiming Chem. J. Chinese Universities    2024, 45 (8): 20240196-.   DOI: 10.7503/cjcu20240196 Abstract （965）   HTML （24）    PDF（pc） （5631KB）（278）       Knowledge map    Save Protein chemical synthesis plays a crucial role in preparing protein with specific sequences and structures. Traditional solid-phase peptide synthesis encounters limitations due to the efficiency of stepwise amino acid coupling and deprotection reactions， posing challenges for synthesizing longer proteins in a single synthesis. Native chemical ligation and peptide hydrazide ligation have significantly facilitated protein synthesis by efficiently connecting unprotected peptide fragments. However， these ligation strategies rely on the relatively low abundance of cysteine in proteins， rendering them unsuitable for synthesizing proteins lacking cysteines or with inappropriate cysteine positions for ligation. The development of protein ligation-desulfurization has surmounted this hurdle by extending ligation sites to alanine and introducing thioamino acids. This innovation liberates protein synthesis from strict ligation site requirements. Moreover， advancements like VA044-based radical desulfurization and emerging desulfurization technologies such as photochemical desulfurization， P-B desulfurization， and iron-catalyzed desulfurization provide diverse options for protein chemical synthesis and expand its application scope. Overall， the chemical methods of protein ligation-desulfurization have undergone continuous evolution and innovation. This not only enriches synthetic methodology but also empowers in-depth investigations in protein engineering and chemical biology. This review provides a comprehensive overview of the development of ligation-desulfurization chemistry approaches in protein chemical synthesis in a timeline format. From the early native chemical ligation and peptide hydrazide ligation based on cysteine sites， to the breakthrough development of ligation-desulfurization strategies， to the exploration of thioamino acids and diversified desulfurization strategies， these techniques have not only enriched the strategies for peptide synthesis， but also demonstrated their broad application and development potential in protein synthesis. We expect that this review will provide insightful and valuable information for researchers in the field of protein chemical synthesis and stimulate further exploration and innovation in this field. Table and Figures | Reference | Related Articles | Metrics

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Discovery of CDK2 Inhibitors Based on Machine Learning and Molecular Dynamics Simulations TAN Yingjia, CHEN Liang, LIU Yulin, NA Risong, ZHAO Xi Chem. J. Chinese Universities    2025, 46 (3): 20240442-.   DOI: 10.7503/cjcu20240442 Abstract （960）   HTML （15）    PDF（pc） （7091KB）（413）       Knowledge map    Save Four potential cyclin-dependent kinase 2（CDK2） inhibitors were discovered through machine learning and molecular dynamics simulation methods. First， a classification model for CDK2 inhibitors was established using existing large-scale activity databases and machine learning algorithms. The extreme gradient boosting（XGBoost） model with extended-connectivity fingerprints（ECFP6） was used to screen the Enamine database， identifying 1152 novel compounds. These potential compounds were then ranked based on their affinity for CDK2 using molecular docking and scoring functions. The compounds were clustered into four categories using fingerprint clustering methods， and one compound with a high docking score was selected from each category. Subsequently， the four selected compounds underwent drug-likeness analysis and molecular dynamics simulations. The four potential CDK2 inhibitors（Z1766368563， Z363564868， Z1891240670 and Z2701273053） demonstrated good drug-likeness properties and high binding free energy in molecular dynamics simulation results. The findings suggest that these four compounds can serve as lead compounds for subsequent modification and optimization as CDK2 inhibitors. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Development of Nucleic Acid Isothermal Amplification Technologies for Virus Detection XIAO Hang, WANG Xiaoyan, DENG Zhaojia, LIAO Wenjing, XIE Wenjing, PENG Hanyong Chem. J. Chinese Universities    2024, 45 (7): 20240139-.   DOI: 10.7503/cjcu20240139 Abstract （960）   HTML （39）    PDF（pc） （11274KB）（185）       Knowledge map    Save Viruses play a significant role in causing human diseases， and traditional PCR techniques have been widely used for their molecular diagnosis. However， the temperature requirements of PCR limit its application in field diagnostics. To address the need for rapid on-site diagnosis， isothermal nucleic acid amplification technologies have emerged as a promising alternative. These technologies enable nucleic acid amplification at a constant temperature without the need for thermal cycling， making them more adaptable for different diagnostic settings. This comprehensive review examines the latest advancements in isothermal amplification technologies for virus detection. It covers various aspects， including viral sample collection， nucleic acid extraction， and isothermal amplification detection. The review explores the principles， key parameters， and applications of enzyme-assisted isothermal amplification， enzyme-free isothermal amplification， and cascade amplification techniques integrated with multiple systems. Furthermore， a comparison of commercially available reagent kits is provided to highlight their respective characteristics. Additionally， the review discusses the current challenges faced by isothermal nucleic acid amplification technologies in pathogen detection， such as extraction efficiency， stability， and cost， and proposes future directions to enhance the on-site diagnostic efficacy of these technologies. Table and Figures | Reference | Related Articles | Metrics

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Construction and Visible Photocatalytic Hydrogen Performance of Hydrangea-like ZnIn2S4/CoWO4 S-scheme Heterojunction ZHAO Yutong, WANG Shikai, ZHAO Fuping, CHEN Zhihe, ZHAO Lijie, ZHANG Dafeng, GE Bo, PU Xipeng Chem. J. Chinese Universities    2024, 45 (5): 20240055-.   DOI: 10.7503/cjcu20240055 Abstract （948）   HTML （27）    PDF（pc） （10957KB）（207）       Knowledge map    Save Rational design of heterojunction structures to accelerate photocatalytic hydrogen evolution plays an indispensable role in the development of photocatalytic materials. ZnIn2S4（ZIS） has been widely used in the field of photocatalytic hydrogen evolution due to its excellent photoelectric properties and negative conduction band position， but it still has serious problems of photogenerated carrier recombination and aggregation. Therefore， the band structure and electron transfer path of ZnIn2S4/CoWO4（ZIS/CWO） S-scheme heterojunction were predicted by theoretical calculation， and the electron exchange at the interface of the heterojunction was determined by electron localization function and charge density difference. Subsequently， CWO nanoparticles were dispersed and fixed on the surface of ZIS flower balls by ultrasonic-agitation-calcination method， and the hydrangea-like ZIS/CWO S-scheme heterojunction was obtained. Owing to the tight interface and the formation of internal electric field between ZIS and CWO， the photogenerated electron-hole pairs in ZIS/CWO S-scheme heterojunction can be effectively separated， thus enhancing the photocatalytic hydrogen evolution performance. Meanwhile， the experimental results confirmed the formation of S-scheme heterojunction and carrier transport path， revealing the in-depth mechanism of photocatalytic hydrogen evolution. This work offers novel insights and approaches for the design， construction， and theoretical calculation of S-scheme heterojunction photocatalysts. Table and Figures | Reference | Related Articles | Metrics

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Electrochemical Analysis of Intracellular Molecules at Single Cells Based on Nanoelectrodes LIU Kang, PAN Rongrong, JIANG Dechen Chem. J. Chinese Universities    2024, 45 (5): 20240027-.   DOI: 10.7503/cjcu20240027 Abstract （945）   HTML （47）    PDF（pc） （5183KB）（273）       Knowledge map    Save Single-cell analysis enables more accurate acquisition of biological information and avoids the loss of single-cell heterogeneity features from averaging analysis， which is essential for studies to elucidate cell metabolism and signaling pathways. Electrochemical analysis techniques based on nanoelectrodes are widely used in single-cell analysis because of their high selectivity， high sensitivity and high spatiotemporal resolution. In this review， the latest research progress of the quantitative analysis of intracellular biomolecules in single cells using nanoelectrodes is reviewed. Moreover， its application in biological research and the challenges are introduced. Table and Figures | Reference | Related Articles | Metrics

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Application of Nanozyme-based Micro/nanomotors in Smart Drug Delivery ZHANG Dang, SUN Xiaomin, YANG Haiyue, SONG Bohan, CONG Meng, WANG Yuxin, DING Feng, XU Shanshan, BI Sai, WANG Lei Chem. J. Chinese Universities    2025, 46 (1): 20240468-.   DOI: 10.7503/cjcu20240468 Abstract （935）   HTML （32）    PDF（pc） （17644KB）（600）       Knowledge map    Save To solve the problems of instability， inactivation of natural enzymes and to tackle the limitations of low delivery efficiency， nanozyme-based micro/nanomotors have been designed and prepared. These motors， with the combination of the efficient and stable catalytic ability of nanozyme and the autonomous motion capability of micro/ nanomotors， could achieve active targeted drug delivery at the diseased site and respond to specific signals for intelligent and controllable drug release， therefore exhibiting significant potential in smart drug delivery applications. Following the developing idea of “from motility， to controllability and applicability”， this paper provides a comprehensive review of various types of nanozymes， discusses the motion regulatory strategies of micro/nanomotors， systematically reviews the cutting-edge applications of nanozyme-based micro/nanomotors in precision drug delivery， and summarizes the challenges and future development prospects for this technology in practical application， wishing to provide fundamental guidance for the development of this field. Table and Figures | Reference | Related Articles | Metrics

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Machine Learning Model for Predicting the Glass Transition Temperature of Polyimides Based on Molecular Fingerprints and Quantum Chemical Descriptors ZHAN Senhua, SHI Tongfei Chem. J. Chinese Universities    2025, 46 (4): 20240556-.   DOI: 10.7503/cjcu20240556 Abstract （915）   HTML （26）    PDF（pc） （2175KB）（187）       Knowledge map    Save Combining machine learning and quantum chemistry methods to construct predictive models can facilitate the design and screening of polyimide material structures. In this study， Molecular ACCess System（MACCS） fingerprints and nine density functional theory（DFT） quantum chemical descriptors were obtained from polyimide repeating units to construct three types of predictive models： MACCS， DFT and their integrated models. Twelve machine learning models were developed using four algorithms——random forest（RF）， support vector regression （SVR）， extreme gradient boosting（XGB） and gradient boosting regression（GBR）——to predict the glass transition temperature of polyimides and extract key feature information. The results showed that the optimal predictive model for the glass transition temperature is the integrated XGBoost model， with coefficient of determination（R²） values of 0.956 and 0.811 for the training and test sets， respectively. The root mean square error（RMSE） and mean absolute error（MAE） for the test set are 25.41 and 20.20， respectively. Furthermore， the integrated MACCS fingerprint and DFT models performed better than the individual models. The established integrated model framework provides new insights for the structural design of polyimide materials and other polymer materials. Table and Figures | Reference | Related Articles | Metrics

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Preparation of Electro-nanofiltration Membranes with High Li+/Mg2+ Separation Performance via Sequential Interfacial Polymerization LIU Huili, WANG Jing, CHEN Jiashuai, SONG Zhihao, JIANG Yumeng, GUO Zhiyuan, ZHANG Panpan, JI Zhiyong Chem. J. Chinese Universities    2024, 45 (6): 20230484-.   DOI: 10.7503/cjcu20230484 Abstract （904）   HTML （30）    PDF（pc） （2953KB）（234）       Knowledge map    Save Highly selective electro-nanofiltration membranes（ENFMs） were prepared by regulating the aqueous-phase monomers of interfacial polymerization（IP） and constructing the positively charged surface by sequential interfacial polymerization（SIP） for the separation of lithium and magnesium by selective electrodialysis processes. The IP reaction was carried out using different aqueous-phase monomers with trimesoyl chloride to achieve the regulation of the pore size and charging property of the separation membranes. The optimum Li+/Mg2+ separation performance（4.75） of the membrane was achieved when piperazine was used as the aqueous-phase monomer. Subsequently， the SIP reaction was utilized to introduce positively charged aqueous-phase monomer polyethyleneimine（PEI， MW=70000） of different concentrations on the optimal IP membrane surface， which converted the charge of the membrane surface from negative to positive. With the increase of PEI concentration， the positive charge density on the membrane surface increased significantly； the optimal SIP membrane achieved outstanding selectivity for Li+/Mg2+（15.90） and high Li+ flux（3.26×10‒8 mol⋅cm‒2⋅s‒1）， which breaks the traditional “Trade-off” effect and lays the foundation for the subsequent research and application of Li+/Mg2+ separation salt-lake brines. Table and Figures | Reference | Related Articles | Metrics