Synthesis and Properties of a Novel Contrast Agent

doi:10.3969/j.issn.0251-0790.2012.02.038

Abstract

Abstract: Chitosan oligosaccharides(CS_n, n=6, 8, 11) with narrow molecular weight distribution and low polymerization degree were introduced into diethylenetriamine pentaacetic(DTPA) by acylation reaction. The synthesized novel ligands were coordinated to Mn²⁺, then the paramagnetic Mn²⁺-based complexes were gained. The structures of synthesized ligands and the corresponding complexes were characterized by IR, elemental analysis, and ICP-AES. The longitudinal relaxivities(r₁) were measured. The results show that r₁ of Mn-DTPA-CS_n are higher than that of commercial contrast agent Gd-DTPA. Besides, the thermodynamical parameters of the interaction between the functional complexes and bovine serum albumin(BSA) were conducted by isothermal titration calorimetry(ITC).

Key words: Contrast agent, Chitosan, Relaxivity, Isothemal titration calorimetry(ITC)

CLC Number:

O636
O657.2

TrendMD:

YANG Xiao-Lu, YANG Xing-Wang, HUANG Yan, ZHANG Qi, WU Jing-Bo, CAO Ben-Nan, ZHANG Xiao-Yan. Synthesis and Properties of a Novel Contrast Agent[J]. Chem. J. Chinese Universities, 2012, 33(02): 426.

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Synthesis and Properties of a Novel Contrast Agent

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