Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier

Chem. J. Chinese Universities

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Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier

ZHA Rui-Tao^1,2, HE Xiao-Ting¹, DU Tian¹, YUAN Zhi¹*

1. Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;
2. College of Material Science and Chemical Engineering, Tianjin University of Science & Technology, Tianjin 300457, China

Received:2006-12-04 Revised:1900-01-01 Online:2007-06-10 Published:2007-06-10
Contact: YUAN Zhi

Abstract

Abstract: Chitosan derivative with glycyrrhetinic acid(GA), which was accumulated specifically in liver, was synthesized. By ion-crosslinking of TPP in GA-CTS solution, GA-CTS-TPP complex nanoparticles were obtained. The physicochemical properties of these nanoparticles were investigated by using TEM and DLS. The experiment in vitro BSA entrapped was studied. GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.

Key words: Glycyrrhetinic acid, Chitosan, Liver targeting

CLC Number:

O625

TrendMD:

ZHA Rui-Tao^1,2, HE Xiao-Ting¹, DU Tian¹, YUAN Zhi¹*. Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier[J]. Chem. J. Chinese Universities, doi: .

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Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier

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