Abstract: Idebenone is a synthetic analog of coenzyme Q₁₀. It has clinical applications in many central ner-vous system degenerative diseases associated with oxidative stress, such as Parkinson's and Alzheimer's diseases, and especially in the therapy of Friedreich's ataxia. According to the established method of synthesizing the quinone using 3,4-cyclopendadiene as auxiliary reagent by Hamamura, the target compound with a good productivity was obtained firstly by using the alkylation reaction of quinone as the key step and coenzyme Q₀ and 1,10-decanediol as the first materials of main body and side chain, respectively, the reactions proceed smoothly under mild conditions to give the expected proucts in good yields. Contrast to the original method, this method is more simple,efficient and practical.

Key words: Idebenone, 1,10- Decanediol, Coenzyme Q₀, 3,4-Cyclopentadiene