Interaction Between Scutellaria baicalensis Georgi and Human Serum Albumin

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (2): 241.

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Interaction Between Scutellaria baicalensis Georgi and Human Serum Albumin

WANG Ning^1,2, LIU Zhong-Ying¹, HU Xiu-Li¹, BU Feng-Quan¹, ZHAO Xue-Zhong^3*

1. College of Pharmacy, Jilin University, Changchun 130021, China;
2. Department of Nephrology, Jilin Province People’s Hospital, Changchun 130021, China;
3. Department of Cardiovascular Medicine, First Hospital of Jilin University, Changchun 130021, China

Received:2010-10-04 Revised:2010-10-18 Online:2010-02-10 Published:2011-02-23
Contact: ZHAO Xue-Zhong E-mail:zhxzh@medmail.com.cn

Abstract

Abstract: In this paper, the interactions of baicalin and wogonoside with human serum albumin (HSA) were studied by fluorescence quenching and ultraviolet-visible absorption spectrometry. The binding constants were obtained by fluorescence quenching of drug with serum albumin. The main acting binding forces of baicalin and wogonoside to serum albumins were hydrophobic force according to the thermodynamic parameters. The effects of metal ions, such as Zn2+, Mg2+, Al3+ and Cu2+on binding constants were also evaluated. It is not only valuable to reveal the pharmacokinetics, clinical therapy, but also have guiding significance for drug design and development of new drugs.

Key words: Baicalin, Wogonoside, Human serum albumin, Fluorescence quenching

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WANG Ning, LIU Zhong-Ying, HU Xiu-Li, BU Feng-Quan, ZHAO Xue-Zhong*. Interaction Between Scutellaria baicalensis Georgi and Human Serum Albumin[J]. Chem. J. Chinese Universities, 2011, 32(2): 241.

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Interaction Between Scutellaria baicalensis Georgi and Human Serum Albumin

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