Chem. J. Chinese Universities ›› 2019, Vol. 40 ›› Issue (9): 1897.doi: 10.7503/cjcu20190167

• Organic Chemistry • Previous Articles     Next Articles

Chemical Constituents and Antitumor Activity of Tupistra chinensis

XIAO Yanhua1,*(),ZHANG Guangjie2,ZONG Liang1,LIU Guohong1,REN Lijun1,DONG Junxing2,*()   

  1. 1. Institute of NBC Defence, Beijing 102205, China
    2. Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2019-03-19 Online:2019-09-10 Published:2019-09-09
  • Contact: XIAO Yanhua,DONG Junxing E-mail:yanhuaxiao@163.com;djx931314@163.com
  • Supported by:
    Supported by the National Science and Technology Major Project of China(2013ZX09J13101-02B)

Abstract:

Tupistra chinensis(Liliaceae), mainly distributed in southwestern China, is a rich source of steroidal sapogenins, saponins and flavans. These components exhibit diverse biological activities such as anti-inflammatory, anti-fungal and anti-tumor properties. As a part of a continuing study for the discovery of novel cytotoxic agents, eight compounds were isolated from the fresh rhizomes of Tupistra chinensis, and their structures were established on the basis of chemical methods and spectral data(MS, IR, NMR), including tupistroside J(1), (25S)-26-O-β-D-glucopyranosyl-furost-1β,3β,22α,26-tetraol-3-O-β-D-glucoside(2), digitoxigenin-3-O-α-L-fucopyranose(3), watti-genin B(4), epiruscogenin(5), epiruscogenin(6), orobol(7), (+)-catechin(8). Compound 1 was a new compound, and compounds 3, 4, 7 and 8 were isolated from Tupistra Ker-Gawl for the first time. All compounds were tested in vitro for their cytotoxic activities against the Human LoVo and BGC-823 cell lines, and compounds 5 and 6 were found to possess significant cytotoxicity against the tested tumor cell lines with half maximal inhibitory concentration(IC50) values of 0.532 and 0.757 μmol/L, respectively.

Key words: Tupistra chinensis baker, Chemical constituent, Antitumor activity

CLC Number: 

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