Synthesis and Properties of Cholesterol Graft Chitosan

doi:10.3969/j.issn.0251-0790.2012.05.045

Abstract

Abstract: Cholesterol-modified chitosan conjugate with succinyl linkages(CHCS) was synthesized and cha-racterized by Fourier transform infrared(FTIR) and proton nuclear magnetic resonance(¹H NMR) spectra. The extent of grafting cholesterol was characterized by elemental analyzer. The properties of CHCS and chitosar(CS) were studied by water contact angle test, biomineralization and cell culture. The results show that the contact angle of CHCS is larger than that of CS. In the process of biomineraliation, CHCS can stable the deposited calcium phosphorus salt. The relationships between CHCS/CS and 3T3 cells were studied by MTT method and cytoske-leton fluorescence staining. The results show that CHCS can promote the cell's adhesion, stretched and proliferation. The introduction of cholesterol can promote the ability of chitosan as biomaterials.

Key words: Bionic, Chitosan, Cholesterol, Modify, Biomineralization, Cell culture

CLC Number:

O636.1

TrendMD:

DING Shan, TANG Min-Jian, ZHOU Chang-Ren, MIN Xiang, TIAN Jin-Huan, LI Li-Hua. Synthesis and Properties of Cholesterol Graft Chitosan[J]. Chem. J. Chinese Universities, 2012, 33(05): 1110.

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Synthesis and Properties of Cholesterol Graft Chitosan

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