Construction of Molecular Imprinted Electrochemical Sensor Based on 2D Ti3C2T x Nanosheet/Conductive Kochen Black Composite Polymethacrylic Acid and the Detection of Dopamine

doi:10.7503/cjcu20250040

Abstract

Abstract:

In this paper， we constructed a poly（methacrylic acid） molecularly imprinted electrochemical sensor based on two-dimensional Ti₃C₂T_x nanosheets/conductive carbon black（KB） composite for the detection of dopamine（DA）. In the beginning， two-dimensional Ti₃C₂T _x nanosheets/conductive KB composites were prepared by wet etching and ultrasonic mechanical mixing techniques and DA was used as the template molecule and methacrylic acid as the functional monomer. Afterwards， a molecularly imprinted polymer film selective for DA was fabricated on the surface of the d-Ti₃C₂T _x /KB modified electrode by electrochemical deposition. The composition and morphology of the materials were analyzed by X-ray diffraction（XRD）， field emission scanning electron microscopy（FESEM） and transmission electron microscopy（TEM）. The electrochemical performance of the modified electrode was investigated by cyclic voltammetry using potassium ferricyanide as an electron probe. The electrochemical response of the electrode to DA was examined by pulse voltammetry. The detection conditions such as the mass ratio of the modified material， the ratio of the template molecule and functional monomer to the cross-linker， the number of electrochemical deposition cycles， the enrichment time， and pH were optimized. The detection results showed that the constructed sensor had a high electrochemical response to DA， with a detection range of 1×10^-6—1×10^-2 mol/L and a minimum detection limit of 4.228 μmol/L（S/N=3）. The sensor exhibited good anti-interference and repeatability. DA in urine samples was detected by the standard addition method， with recovery rates ranging from 82.5% to 93.75% and RSDs all below 5%. The DA detection molecularly imprinted electrochemical sensor constructed in this experiment has high sensitivity and reliability， providing a method and idea for the detection of DA samples.

Key words: Dopamine, Electrochemical sensor, Molecular imprinting, MXenes, Ti₃C₂T _x, Ketjen black

CLC Number:

O657.11

TrendMD:

REN Shufang, GUO Tong, WANG Zihan, LIU Yahui, CHEN Yu, ZENG Junling. Construction of Molecular Imprinted Electrochemical Sensor Based on 2D Ti₃C₂T _x Nanosheet/Conductive Kochen Black Composite Polymethacrylic Acid and the Detection of Dopamine[J]. Chem. J. Chinese Universities, 2025, 46(7): 20250040.

Figures/Tables 6

References 34

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Simulated sample	Added/（mmol·L^-1）	Detected/（mmol·L^-1）	Recovery（%）	RSD（%， n=3）
Human urine	0	0	0	0
	0.100	0.087	87.00	2.7
	0.040	0.033	82.50	4.3
	0.016	0.015	93.75	4.5

Simulated sample	Added/（mmol·L^-1）	Detected/（mmol·L^-1）	Recovery（%）	RSD（%， n=3）
Human urine	0	0	0	0
	0.100	0.087	87.00	2.7
	0.040	0.033	82.50	4.3
	0.016	0.015	93.75	4.5

Construction of Molecular Imprinted Electrochemical Sensor Based on 2D Ti₃C₂T _x Nanosheet/Conductive Kochen Black Composite Polymethacrylic Acid and the Detection of Dopamine

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