Table of Content

10 July 2025, Volume 46 Issue 7

Previous Issue   

Content

Cover and Content of Chemical Journal of Chinese Universities Vol.46 No.7(2025)

2025, 46(7):  1-6. 

Asbtract ( )   PDF (22117KB) ( )  

Related Articles | Metrics

Review

Nucleic Acid-based Protein Labeling Tools for Visualization of Membrane Receptors

CHEN Shan, ZHUO Yufei, LI Jingying

2025, 46(7):  20240567.  doi:10.7503/cjcu20240567

Asbtract ( )   HTML ( )   PDF (15663KB) ( )  

Figures and Tables | References | Related Articles | Metrics

Dynamic and complex cellular activities， such as cell communication and signal transduction， rely on the participation of various membrane receptors. Nucleic acids are important tools for developing membrane receptor visualization strategies in live cells. In this review， protein labeling techniques based on nucleic acid probes are summarized from two aspects： non-covalent target recognition and covalent coupling. The latest research progress of these labeling techniques in the visualization of important molecular information， such as membrane receptor expression， glycoform and protein-protein interactions， was systematically reviewed. The existing challenges and future development in this field were discussed and prospected.



Articles: Inorganic Chemistry

SiO₂ Solid-state Nanopore Films Prepared by Wet Etching Ag Nanowire Arrays

XIN Ruochen, LI Guohua, GAO Junhua, CAO Hongtao

2025, 46(7):  20250005.  doi:10.7503/cjcu20250005

Asbtract ( )   HTML ( )   PDF (7258KB) ( )  

Figures and Tables | References | Related Articles | Metrics

Solid-state nanopore films are used widely in biological detection， life and health， and other sectors because they are more chemically， mechanically， and thermally stable than traditional biological nanopore films. Using a multi-target magnetron co-sputtering system， silver（Ag） nanowire array-silicon dioxide（SiO₂） composite metamaterial films were created. The Ag nanowire arrays were selectively dissolved by hydrogen peroxide（H₂O₂） solution， and chemical wet etching produced SiO₂ solid nanopore array films with an average diameter of about 5 nm. X-ray diffraction， inductively coupled plasma optical emission spectroscopy and spectroscopic ellipsometry were used to confirm the complete dissolution of Ag nanowires in H₂O₂ solution， and the chemical reaction mechanism between Ag nanowires and H₂O₂ was clarified. In addition， scanning electron microscopy and small-angle X-ray scattering were used to characterize the morphology and microstructure size of SiO₂ solid state nanopore array. In this study， SiO₂ solid state nanopore arrays with a diameter of less than 10 nm were successfully fabricated， which provides a new idea for the efficient preparation of solid-state nanopore arrays.



Analytical Chemistry

Fluorescent Detection of Sulfite Ions（SO²₃ ^-） Based on Cerium-functionalized Metal-organic Framework UiO-66-（COOH）₂

GONG Wenpeng, ZHOU Linnan

2025, 46(7):  20250062.  doi:10.7503/cjcu20250062

Asbtract ( )   HTML ( )   PDF (3980KB) ( )  

Figures and Tables | References | Related Articles | Metrics

A fluorescence strategy was constructed based on the metallic organic framework Ce-UIO-66-（COOH）₂ to detect SO{}_{\mathrm{3}}^{\mathrm{2}}^-. Firstly， under solvothermal conditions， the Ce-UIO-66-（COOH）₂ was synthesized using homophthallic acid and Ce⁴⁺ as the organic ligand and central ion. The structure was characterized by X-ray diffraction（XRD）， infrared spectroscopy（IR）， X-ray photoelectron spectroscopy（XPS）， scanning electron microscope（SEM） and energy dispersive spectroscopy（EDS）. Employing a reaction system using Ce-UIO-66-（COOH）₂， SO{}_{\mathrm{3}}^{\mathrm{2}}^- and benzoic acid， under the catalysis of Ce-UiO-66-（COOH）₂， the SO{}_{\mathrm{3}}^{\mathrm{2}}^- was conversed to sulfate radical SO{}_{\mathrm{4}}^{·}^-， and then induced benzoic acid to transform into fluorescent molecule 2-hydroxybenzoic acid（salicylic acid）， which realizes the detection of SO{}_{\mathrm{3}}^{\mathrm{2}}^-. The detection mechanism was confirmed by fluorescence spectrum and ESR. The influences of time， temperature， dosages of MOF and benzoic acid were explored. Under the optimal conditions， a linear detection range was obtained as 40—120 μmol/L， and the detection limit was 8.3 μmol/L. The method possesses the favourable anti-interference property for common inorganic anions. Meanwhile， it was applied to the determination of SO{}_{\mathrm{3}}^{\mathrm{2}}^- in rainwater and tap water samples， the results are satisfactory.



Construction of Molecular Imprinted Electrochemical Sensor Based on 2D Ti₃C₂T _x Nanosheet/Conductive Kochen Black Composite Polymethacrylic Acid and the Detection of Dopamine

REN Shufang, GUO Tong, WANG Zihan, LIU Yahui, CHEN Yu, ZENG Junling

2025, 46(7):  20250040.  doi:10.7503/cjcu20250040

Asbtract ( )   HTML ( )   PDF (6450KB) ( )  

Figures and Tables | References | Related Articles | Metrics

In this paper， we constructed a poly（methacrylic acid） molecularly imprinted electrochemical sensor based on two-dimensional Ti₃C₂T_x nanosheets/conductive carbon black（KB） composite for the detection of dopamine（DA）. In the beginning， two-dimensional Ti₃C₂T _x nanosheets/conductive KB composites were prepared by wet etching and ultrasonic mechanical mixing techniques and DA was used as the template molecule and methacrylic acid as the functional monomer. Afterwards， a molecularly imprinted polymer film selective for DA was fabricated on the surface of the d-Ti₃C₂T _x /KB modified electrode by electrochemical deposition. The composition and morphology of the materials were analyzed by X-ray diffraction（XRD）， field emission scanning electron microscopy（FESEM） and transmission electron microscopy（TEM）. The electrochemical performance of the modified electrode was investigated by cyclic voltammetry using potassium ferricyanide as an electron probe. The electrochemical response of the electrode to DA was examined by pulse voltammetry. The detection conditions such as the mass ratio of the modified material， the ratio of the template molecule and functional monomer to the cross-linker， the number of electrochemical deposition cycles， the enrichment time， and pH were optimized. The detection results showed that the constructed sensor had a high electrochemical response to DA， with a detection range of 1×10^-6—1×10^-2 mol/L and a minimum detection limit of 4.228 μmol/L（S/N=3）. The sensor exhibited good anti-interference and repeatability. DA in urine samples was detected by the standard addition method， with recovery rates ranging from 82.5% to 93.75% and RSDs all below 5%. The DA detection molecularly imprinted electrochemical sensor constructed in this experiment has high sensitivity and reliability， providing a method and idea for the detection of DA samples.



Organic Chemistry

Semi-continuous Flow Synthesis of 2-Methyl-5-aminophenol

WU Junhui, WU Jiajia, PAN Shuangye, CHEN Jianai, TAN Chengxia

2025, 46(7):  20250053.  doi:10.7503/cjcu20250053

Asbtract ( )   HTML ( )   PDF (1502KB) ( )  

Figures and Tables | References | Related Articles | Metrics

2-Methyl-5-aminophenol is a crucial high-activity intermediate extensively utilized in the fields of dyes， pharmaceuticals and cosmetics， with a continuously increasing market demand. However， traditional industrial production methods are characterized by high energy consumption， long reaction times and safety concerns. Based on the technical advantages of continuous flow reactors， a semi-continuous flow synthesis process was developed in this work. By transforming the production processes of three key intermediates into continuous flow processes， the reaction time was significantly reduced from 12 h to just 4 min， and the final product separation yield reached 78.5%. This innovative approach not only significantly improved the reaction efficiency， but also optimized the process conditions， making the product generation more stable， while effectively reducing energy consumption and safety risks. The research results provide an valuable reference for the integrating continuous flow technology with green and efficient industrial production.



Engineering Stimuli-responsive RNA-cleaving DNAzymes in Organic Cosolvents

HE Rongrong, YOU Xin, ZHENG Xing, YANG Menghan, CHANG Tianjun

2025, 46(7):  20250010.  doi:10.7503/cjcu20250010

Asbtract ( )   HTML ( )   PDF (1567KB) ( )  

Figures and Tables | References | Supplementary Material | Related Articles | Metrics

Engineering deoxyribozyme（DNAzyme） by the introduction of new recognition elements is an important approach for expanding its applications， however， this depends on the systematic characterization of the engineerable sites in the DNAzyme. In this work， we investigated the engineerable sites of an organic solvent-needing RNA- cleaving DNAzyme（RCD， named E3） previously reported by our group. We first split E3 into two parts at its variable region， and added two DNA sequences on the 5′-end of one part and 3′-end of the other part to form duplex to activate the DNAzyme. By construction of the zipper-like Multiple Component DNAzyme（MNAzyme）， we were able to identify 6 splitting sites that could be utilized for DNAzyme engineering. Based on this discovery， a DNAzyme system that was activated by an external DNA initiator was constructed by splitting E3 at its variable region and introducing two oligonucleotides at the split sites for the binding of the initiator. Furthermore， we identified several splitting sites on the substrate-binding arm of E3 as an alternative region for the design of MNAzyme. Application in both regions， an intricate three component DNAzyme system was designed to be activated only in the presence of the two specific initiators. All the MNAzyme systems exhibited extremely high selectivity and very low background both in 35%（volume fraction） DMSO and 30%（volume fraction） ethanol solvents. Moreover， in mixing of various MNAzyme systems and all the relative initiators， the cleavage products were almost the sum of that in mixing these MNAzymes in the presence of individual initiator. These results demonstrate that E3 is an excellent scaffold for constructing responsive RCD probes in applications in organic solvents-containing scenarios.



Synthesis of Benzo⁃thioethers Based on the Intramolecular Selective C—S Cleavage of Arylthianthreniums

NAN Jiang, XU Kailun, YAN Qiang

2025, 46(7):  20240538.  doi:10.7503/cjcu20240538

Asbtract ( )   HTML ( )   PDF (1929KB) ( )  

Figures and Tables | References | Supplementary Material | Related Articles | Metrics

Here reported is an intramolecular nucleophilic substitution reaction of aryl-thianthrenium salts， which conducts the selective cleavage of C—O and C—S chemical bonds and represents a novel conversion of aryl-thianthreniums， rapidly assembling the highly conjugated tribenzo-thioester compounds. This developed methodology is charactered by excellent functional group tolerance， good productivities， and metal-free trait. This conversion delivers 23 examples of structurally innovative nine-membered thioethers， which puts forward an alternative synthesizing route for the widely used crown ethers.



Physical Chemistry

Enhancing Methanol Oxidation Reaction by NiO Featuring High Concentration of Oxygen Vacancy and Ni³⁺/Ni²⁺ Ratio

LU Jiantian, ZHAO Manzhen, ZHANG Baohua, SONG Shuang, ZHANG Yuwei

2025, 46(7):  20250073.  doi:10.7503/cjcu20250073

Asbtract ( )   HTML ( )   PDF (4733KB) ( )  

Figures and Tables | References | Supplementary Material | Related Articles | Metrics

To address the critical challenges of insufficient active sites， poor conductivity， and sluggish reaction kinetics in nickel-based electrocatalysts for methanol oxidation reaction（MOR）， this study proposes a lattice doping engineering strategy. By employing a low-cost ammonium molybdate precursor coupled with a calcination process， we successfully constructed Mo-doped NiO catalysts synergistically enhanced by oxygen vacancies and Ni³⁺ active sites. Experimental results demonstrate that as the Mo doping level increases from 0 to 28%（atomic fraction）， the oxygen vacancy concentration on the catalyst surface escalates progressively from 30.18% to 56.59%， while the proportion of Ni³⁺ species rises from 65.55% to 85.91%. At an optimal Mo doping content of 28%， the catalyst achieves a current density of 280.8 mA/cm² at 1.7 V（vs. RHE） in 1.0 mol/L KOH/1.0 mol/L CH₃OH electrolyte， representing a 12.9-fold enhancement compared to undoped NiO（21.7 mA/cm²）. Furthermore， the Tafel slope decreases signifi-cantly from 63 mV/dec to 25 mV/dec. Systematic characterizations via XRD， SEM， TEM and XPS elucidate the formation mechanism of Mo-doped NiO catalysts with tunable oxygen vacancy concentrations and Ni³⁺/Ni²⁺ ratios， as well as their MOR electrocatalytic performance. A preliminary structure-activity relationship is established， revealing the underlying principles of enhanced activity. This work provides a novel approach for designing efficient anode catalysts for direct methanol fuel cells（DMFCs） with high active site density.



Determination of Acidic Ionic Liquid H₀ and the Effect of Salt Effect

WANG Zhiyuan, DONG Yi, QI Baohui, WEI Xueyang, ZHANG Jiahui, HUANG Qizhong, LI Jisheng, GAO Na, DI Shiying, HU Yufeng

2025, 46(7):  20240535.  doi:10.7503/cjcu20240535

Asbtract ( )   HTML ( )   PDF (1200KB) ( )  

Figures and Tables | References | Related Articles | Metrics

The catalytic activity of ionic liquids is closely related to their acidity， and the Hammett acidity function （H₀） is one of the most important parameters to represent acidity. In this paper， we synthesized a series of pyrrolidinone-based and imidazolium-based ionic liquids that can be used in the synthesis process of 1，3，5-trioxane， and conducted systematic experimental and theoretical studies on their H₀ in aqueous solution. The influence of anionic and cationic structures and solvent selection on acidity were compared. The effect of salt effect on the H₀ determination of 1-propylsulfonic-3-methylimidazolium methanesulfonate（［C₃SMIM］［MSA］）， methanesulfonic acid， trifluoromethanesulfonic acid， and sulfuric acid was studied. The results indicate that anions have a more significant impact on acidity. When the anions are the same， the longer the carbon chain of the cation substituent is， the stronger the acidity will be； When the cations are the same， the lower the charge density of the anions is， the stronger the acidity will be； For the same type of ionic liquid， ionic liquids functionalized with sulfonic acid have stronger acidity than those that are not functionalized. Most salts have a salting out effect， which enhances acidity， while a few salts weaken acidity， such as sodium p-toluenesulfonate and 1-propylsulfonic-3-methylimidazolium salt（C₃SMIM）. The common characteristics of these salts are large ion size and low charge density.



Sodium Storage Performance of Antimony Electrodes Synergistically Enhanced by Three-dimensional Porous Structure and Alloying with Indium

SUN Yuhan, JING Maosen, ZHAO Baoyan, BAO Xiaobing, LUO Qiaomei, GOU Lei, FAN Xiaoyong

2025, 46(7):  20250034.  doi:10.7503/cjcu20250034

Asbtract ( )   HTML ( )   PDF (7860KB) ( )  

Figures and Tables | References | Related Articles | Metrics

Antimony（Sb） is considered as an ideal anode for sodium-ion batteries due to its high theoretical sodium storage capacity of 660 mA·h/g. However， its commercial application is impeded by significant volume changes during charge-discharge cycling， which lead to the pulverization and shedding of the active materials. To address these issues， this study employed a simple electro-deposition method to fabricate an InSb alloy on a three-dimensional porous copper current collector with micrometer-sized pores（3D Cu@InSb）. The introduced indium（In） element effectively suppresses the aggregation of Sb electrodes， the occurrence of irreversible reactions， and thus enhances the initial Coulombic efficiency. Meanwhile， the three-dimensional porous structure provides a large specific surface area and abundant active sites， which not only increase the sodium storage capacity and ion diffusion rate but also offer enough buffer space for volume expansion， thereby enhancing the structural stability of the material. Under the synergistic effect of the In element and the three-dimensional porous structure， the 3D Cu@InSb electrode exhibits a high initial Coulombic efficiency of 80.7%， good cycling stability（a capacity retention rate of 97.6% after 400 cycles at a current density of 10 A/g）， and excellent rate performance（a specific capacity of 225.4 mA·h/g at a high current density of 20 A/g）.



Electrolytes Design and Electrochemical Performance for Lithium Metal Batteries Based on Fluorosiloxane Solvents

LIANG Yi, HUANG Dequan, YIN Guangda, WEN Gang, QIN Weixian, YAO Yuan, WEI Tao

2025, 46(7):  20250024.  doi:10.7503/cjcu20250024

Asbtract ( )   HTML ( )   PDF (8161KB) ( )  

Figures and Tables | References | Related Articles | Metrics

Addressing the issues of lithium dendrite growth， unstable electrode/electrolyte interface， and poor oxidation stability in ethylene glycol dimethyl ether（DME） electrolyte in lithium metal batteries， this work uses trimethoxy（3，3，3-trifluoropropyl） silane（TFS） as the electrolyte solvent and combines with lithium difluorosulfonylimide（LiFSI） salt to design a novel fluorinated siloxane electrolyte. The lithium solvation structure of the electrolyte were analyzed by density functional theory（DFT） and molecular dynamics simulations（MD）. The electrochemical performance of the cells in fluorinated siloxane electrolyte and DME electrolyte were compared and analyzed through charge discharge tests， cycle performance tests， and rate performance tests. The lithium deposition morphology and electrode interface composition were analyzed by scanning electron microscopy（SEM） and X-ray photoelectron spectroscopy（XPS）. As a result， the Si—O bond in TFS has a higher bond energy than the C—O bond in DME electrolyte， which can enhance the oxidation stability of the electrolyte and match high-voltage cathode materials. In addition， TFS solvent exhibits relatively weak binding ability with Li⁺， and this unique lithium solvation structure is conductive to inducing preferentially decompose of FSI^‒ anions on the surface of lithium metal anode and forming LiF-rich solid electrolyte interphase（SEI） films， effectively inhibiting lithium dendrite growth， stabilizing the electrode interface， and improving the cycle life of lithium metal batteries. In TFS electrolyte， the Li 􀰙􀰙 Cu cell can be stably cycled for 300 cycles at a current density of 1.0 mA/cm²， the Li 􀰙􀰙 LFP full cell shows no significant capacity degradation after 400 cycles at a rate of 2.0C， and the Li 􀰙􀰙 CNCM811 full cell maintains a discharge specific capacity retention rate of 83% after 300 cycles at a rate of 1.0C， demonstrating excellent cycling stability.



D-A Type Covalent Organic Framework Nanorods for Visible Light Catalyzed Benzylamine Coupling Reaction

ZHANG Xiaohui, ZHAO Dongdong, ZHANG Junjie, ZHUANG Jinliang

2025, 46(7):  20250020.  doi:10.7503/cjcu20250020

Asbtract ( )   HTML ( )   PDF (8322KB) ( )  

Figures and Tables | References | Related Articles | Metrics

Covalent organic frameworks（COFs） are a new type of covalently bonded crystalline materials with predictable structures and permanent porosity. COFs have found extensive applications in heterogeneous catalysts. In this study， organic monomers containing photoactive pyrene groups（TFPPy） and benzothiadiazole（BTz） were used as building units for the construction of COFs. The donor-acceptor（D-A） type TFPPy-BTz-COF nanorods photocatalysts were successfully synthesized via a solvent-thermal method. The morphology， structure， and composition of TFPPy-BTz-COF were characterized by scanning electron microscopy（SEM）， high-resolution transmission electron microscopy（HRTEM）， X-ray diffraction（XRD）， UV-Vis diffuse reflectance spectroscopy（UV-Vis DRS）， Fourier-transform infrared（FTIR） spectroscopy， and N₂ adsorption-desorption measurements. The as-synthesized TFPPy-BTz-COF nanorods exhibit a rod-like morphology with a high degree of crystallinity， a specific surface area（BET） of 118.86 m²/g， and a band gap（E_g） of 2.30 eV. Benefiting from their efficient photogenerated photo-electron pair ability， the TFPPy-BTz-COF nanorods enable the coupling reaction of various amines with high efficiency and selectivity under conditions of room temperature， oxygen atmosphere， and visible light irradiation. Electron paramagnetic resonance spectroscopy（EPR） and active species trapping experiments suggested that the singlet oxygen （¹O₂） and superoxide radical（{\mathrm{O}}_{\mathrm{2}}^{\bullet -}） are key intermediates， and a catalytic mechanism for the visible light mediated photocatalytic oxidation coupling of benzylamines catalyzed by TFPPy-BTz-COF was proposed.



Synthesis of the PtxZn/MSN Catalysts and Their Propane Dehydrogenation Properties

WANG Wenxin, SHAN Yiou, SONG Jiaxin, FAN Xiaoqiang, YU Xuehua, KONG Lian, XIAO Xia, XIE Zean, ZHAO Zhen

2025, 46(7):  20250011.  doi:10.7503/cjcu20250011

Asbtract ( )   HTML ( )   PDF (4703KB) ( )  

Figures and Tables | References | Related Articles | Metrics

With the increasing demand of propylene in society， the development of efficient propylene production technology is crucial for both science and the economy. Platinum-based catalysts have been widely studied in propane dehydrogenation（PDH） reactions due to their high ability to activate propane C—H bonds and selectivity towards propylene. In this work， mesoporous silica nanoparticles（MSN） with confinement effect were used as the support， and transition metal zinc was selected as a promoter to control the electronic properties and geometric structure of platinum. PtxZn/MSN catalysts with different zinc loadings were prepared by the impregnation method and the products were characterized by X-Ray diffraction（XRD）， N₂ adsorption-desorption， Raman spectra， CO diffuse reflective infrared Fourier transform spectroscopy（CO-DRIFT）， scanning electron microscope（SEM）， transmission electron microscope（TEM） and X-ray photoelectron specroscopy（XPS）. the PDH performance of PtxZn/MSN was tested. When the zinc loading was 0.5%（mass fraction）， PtxZn/MSN catalyst showed the highest PDH activity with the initial propane conversion and propylene selectivity of 47.9% and 97.0%， respectively. After 6 h reaction， the propane conversion and propylene selectivity were 45.8% and 97.0%， with the propylene production rate of 0.82 mmol/min·g_cat. The characterization results demonstrated that the addition of Zn divided Pt particles into smaller Pt species， which can improve the dispersion of Pt， reduce the occurrence of side reactions， and enhance the stability of the catalyst.



Polymer Chemistry

Surface Modification of PMMA and Polyester Materials by One-pot Method and Anti-biofouling Performance Evaluation of the Coatings

ZHAO Ying, DONG Jicheng, FANG Yuan, ZHANG Lijun, JIN Lin, LIU Bo, CHENG Fang

2025, 46(7):  20240566.  doi:10.7503/cjcu20240566

Asbtract ( )   HTML ( )   PDF (8419KB) ( )  

Figures and Tables | References | Related Articles | Metrics

A generalized method for surface modification of poly（methyl methacrylate）（PMMA） and polyester materials has been reported to prepare broad-spectrum and subsequently reactive coatings， which have anti-protein and anti-bacterial properties. The method also overcomes the common limitation of surface modification by introducing specific groups. The zwitterionic monomer（sulfobetaine methacrylate， SBMA） was polymerized on PMMA by one-pot method and two-step method， respectively. The elemental analysis results showed that the PMMA-SBMA modified coating prepared by one-pot method had the highest SBMA content， so the one-pot method was selected for follow-up study. At the same time， the optimized modification method was verified to be broad-spectrum on the surface of other polyester materials including polybutylene terephthalate（PBT）， polycarbonate（PC）， poly（1，4- cyclohexanedicarbinol） terephthalate（PCT） and polyethylene terephthalate（PET）. Ellman’s assay showed that vinyl sulfone groups were still present on the PMMA-SBMA’s surface of the modified coating， indicating that the coating had sustainable subsequent reactivity. The anti-biological scale experiment of the PMMA-SBMA modified coating was carried out. The anti-BSA adsorption capacity of the coating was evaluated by quartz electronic microbalance（QCM）， and the results showed that the one-pot coating significantly reduced the non-specific adsorption of protein by 72.3%. For Bacillus cereus， Escherichia coli and Staphylococcus aureus， the bacterial adhesion area of the static coating was reduced by more than 80%. The results of flow pool and flow field calculation showed that the bacterial adhesion ability can be resisted under the flow conditions of two shear forces（0.16 and 1.6 dynes/cm²）.



Preparation of Hyperbranched Poly（ethylene glycol）s via Reversible Addition-fragmentation Chain Transfer Free Radical Polymerization of Multivinyl Monomers and Their Application in Stem Cell Culture

LI Zhili, ZHOU Dezhong

2025, 46(7):  20240546.  doi:10.7503/cjcu20240546

Asbtract ( )   HTML ( )   PDF (5479KB) ( )  

Figures and Tables | References | Supplementary Material | Related Articles | Metrics

Using poly（ethylene glycol） diacrylate（PEGDA） as the multivinyl monomers（MVMs）， 4-cyano-4-（phenylcarbonothioylthio）pentanoic acid（CPADB） as the chain transfer agent， and 2，2'-azobisisobutyronitrile（AIBN） as the initiator， two hyperbranched poly（ethylene glycol）s（HBPs） with different branching degrees and multiple pendent vinyl groups were successfully prepared in a one-pot reversible addition-fragmentation chain transfer（RAFT） polymerization by regulating reaction parameters to specifically promote intermolecular combination. HBPs can react with thiolated gelatin（gel-SH） via thiol-ene click chemistry to form HBP/gel-SH hydrogels and be used for the culture of human induced mesenchymal stem cells（iMSCs）. The chemical composition and structure of the HBPs were characterized using gel permeation chromatography（GPC） and nuclear magnetic resonance spectrometry. Research results indicated that the branching degrees of HBPs can be effectively regulated by adjusting PEGDA monomer reaction concentration and n（PEGDA）∶n（CPADB）∶n（AIBN）. Rheological analysis showed that HBPs and gel-SH could cross-link to form a hydrogel within 2 min. Cell culture experiments demonstrated that the HBP/gel-SH hydrogels exhibited no significant cytotoxicity， and the hydrogel formed by the higher branching polymer displayed better biocompatibility. These hydrogels hold great potential for applications in stem cell culture and expansion.



Material Chemistry

Synergistically Improving Osteogenic Properties of TiO₂ Nanotubes on Titanium Surface by Sr²⁺/NO/OGP

PAN Changjiang, MA Wenfu, DING Pingyun, ZHANG Qiuyang, DENG Linhong

2025, 46(7):  20240523.  doi:10.7503/cjcu20240523

Asbtract ( )   HTML ( )   PDF (13586KB) ( )  

Figures and Tables | References | Related Articles | Metrics

In this study， anodization and hydrothermal treatment techniques were first employed to prepare Sr²⁺-loaded TiO₂ nanotube arrays on the titanium surface. Then， carboxymethyl chitosan（CMCS） coating was fabricated on the nanotube surface by electrophoretic deposition. Finally， NO-releasing molecules（N-Nitroso-N-phenylhydroxylamine ammonium salt， Cupferron） and osteogenic growth peptides（OGP） were sequentially loaded into the nanotubes， achieving synergistically promoting osteoblast adhesion， proliferation， and functional expression by Sr²⁺， NO gas molecule， and OGP. The results indicated that the functionalized nanotube arrays could not only induce biomimetic deposition of hydroxyapatite（HA）， but also continuously release Sr²⁺ and NO gas signaling molecules， significantly promoting the adhesion and growth of osteoblasts， as well as the expressions of alkaline phosphatase（ALP）， osteocalcin（OCN）， and Runt related transcription factor 2（RUNX2）. After loading OGP， the osteoblast adhesion， growth， and functional expression were further enhanced. Therefore， the surface modification strategy of the present study can be used to construct the bioactive coating with excellent biocompatibility on titanium alloy surfaces to improve the bone integration ability of titanium-based bone-substituted materials.



Environmental Chemistry

Recycling Treatment of Unsymmetrical Dimethylhydrazine High-salinity Wastewater via "Electrodialysis+Reverse Osmosis" Double Membrane Processes

XUE Linyong, ZHU Helin, ZHANG Nian, WU Yannan, YANG Zhenmiao, WEI Chenjie, LIU Lifen

2025, 46(7):  20250039.  doi:10.7503/cjcu20250039

Asbtract ( )   HTML ( )   PDF (2279KB) ( )  

Figures and Tables | References | Supplementary Material | Related Articles | Metrics

Unsymmetrical dimethylhydrazine（UDMH） is the main fuel for missile， satellite and spacecraft launch tests as well as carrier rockets. Its production wastewater contains high concentrations of salt， alkali and UDMH. Direct discharge of the UDMH wastewater can cause water and soil pollution， seriously endangering human health. Therefore， this paper designed a kind of “electrodialysis+reverse osmosis” double membrane processes for recycling treatment of the high salinity UDMH wastewater. Firstly， the electrodialysis（ED） was used to remove the impunities of salt and base in the wastewater， and then the reverse osmosis（RO） was carried out to further concentrate the desalinated wastewater for the highly purified recovery of UDMH. Meanwhile， the influences of ion exchange membrane， operating voltage and feed liquid flow rate on desalination process of ED were investigated， and the concentration technique of reverse osmosis process was also optimized. The research results showed that the electrodialysis process can remove 98.6% of NaCl and base（NaOH， ect.）， the loss rate of UDMH is less than 13.5%， the current efficiency can reach 53.1%， and the process energy consumption is about 1.02 kW·h/kg. The concentration of UDMH is concentrated from 1.1 g/L to 6.3 g/L， and the concentration ratio of UDMH is about 5.6 times， which meets the reuse requirement of UDMH.