Chem. J. Chinese Universities ›› 2014, Vol. 35 ›› Issue (8): 1835.doi: 10.7503/cjcu20131236
• Polymer Chemistry • Previous Articles Next Articles
GUO Hua, YANG Chengling, WANG Wei, LAI Quanyong, YUAN Zhi*()
Received:
2013-12-17
Online:
2014-08-10
Published:
2019-08-01
Contact:
YUAN Zhi
E-mail:zhiy@nankai.edu.cn
Supported by:
CLC Number:
TrendMD:
GUO Hua, YANG Chengling, WANG Wei, LAI Quanyong, YUAN Zhi. Preparation of Liver-targeted Nano-prodrug Based on Sodium Alginate Derivative and the Study on Antitumor Activity†[J]. Chem. J. Chinese Universities, 2014, 35(8): 1835.
Fig.1 Structures of DOX-ALG-mOEG(A) and GA-ALG-mOEG(B) and schematic representation of DOX-ALG-mOEG/GA-ALG-mOEG NPs from DOX-ALG-mOEG and GA-ALG-mOEG(C)
Sample | Dh/nm | PDI* | Zeta potential/mV | CAC/(mg·L-1) |
---|---|---|---|---|
DOX-ALG/GA-ALG NPs | 253.5 | 0.123 | -44.4 | 58.34 |
DOX-ALG-mOEG/GA-ALG-mOEG NPs | 254.2 | 0.207 | -35.1 | 5.52 |
Table 1 Characterization of DOX-ALG-mOEG/GA-ALG-mOEG NPs and GA-ALG/DOX-ALG NPs
Sample | Dh/nm | PDI* | Zeta potential/mV | CAC/(mg·L-1) |
---|---|---|---|---|
DOX-ALG/GA-ALG NPs | 253.5 | 0.123 | -44.4 | 58.34 |
DOX-ALG-mOEG/GA-ALG-mOEG NPs | 254.2 | 0.207 | -35.1 | 5.52 |
Fig.4 In vitro cumulative release of DOX-ALG-mOEG/GA-ALG-mOEG NPs(a, b) and DOX-ALG/GA-ALG NPs(c, d) in PBS under acidic(pH=4.0)(a, c) and neutral(pH=7.4)(b, d) condition
Fig.5 CLSM images of HepG2 cells after the treatment with DOX-ALG/GA-ALG NPs(A1—A3) and DOX-ALG-mOEG/GA-ALG-mOEG NPs(B1—B3) (A1, B1) DOX; (A2, B2) Hoechst; (A3, B3) Overlay.
Fig.6 CLSM images of HepG2 cells after treatment with DOX/GA-ALG NPs(A1—A3) and DOX/GA-ALG NPs+PEG-GA(B1—B3) (A1, B1) DOX; (A2, B2) Hoechst; (A3, B3) Overlay.
Fig.8 Representative photographs(A) and ultimate tumor mass(B) of excised H22 tumors from mice treated with saline(a), DOX·HCl(b), DOX-ALG/GA-ALG NPs(c) and DOX-ALG-mOEG/GA-ALG-mOEG NPs(d)[means±SD(n=3—5), * P<0.05]
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