Adsorbents for Endotoxin Based on Chitosan Matrix

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (4): 680.

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Adsorbents for Endotoxin Based on Chitosan Matrix

WANG Hui-Yan¹, HOU Guang-Hui¹, YU Mei¹, YUAN Zhi¹, LIU Bin², ZHAO Cheng-Mei²

1. State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;
2. Tianjin Medical College, Tianjin 300052, China

Received:2004-05-11 Online:2005-04-10 Published:2005-04-10

Abstract

Abstract: The endotoxin adsorbents were prepared by coupling divinyl amine ligands on crosslinked chitosan matrix. Their adsorption ability to endotoxin was compared. It was found that the adsorbent with polyethylene polyamine ligand had the highest adsorption capacity and its clearance percent for endotoxin in endotoxemia plasma was over 80. The results also showed that the adsorbent has good blood compatibility and clinical application foreground.

Key words: Chitosan, Endotoxin, Adsorbent, Hemoperfusion.

CLC Number:

O626
R914

TrendMD:

WANG Hui-Yan, HOU Guang-Hui, YU Mei, YUAN Zhi, LIU Bin, ZHAO Cheng-Mei. Adsorbents for Endotoxin Based on Chitosan Matrix[J]. Chem. J. Chinese Universities, 2005, 26(4): 680.

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Adsorbents for Endotoxin Based on Chitosan Matrix

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