Preparation of PEGT/PBT Tissue Engineering Scaffolds by Solution Spray Method

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (1): 175.

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Preparation of PEGT/PBT Tissue Engineering Scaffolds by Solution Spray Method

LIU Hou-Li¹, CHEN Jin-Wu², WANG Lian-Cai¹, WANG Chang-Yong², FENG Zeng-Guo¹

1. School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China;
2. Tissue Engineering Research and Development Center, Beijing Institute of Basic Medical Sciences, Academy Military Medical Science, Beijing 100850, China

Received:2003-11-04 Online:2005-01-10 Published:2005-01-10

Abstract

Abstract: A novel method for solution spray at a high nitrogen pressure was applied in the preparation of tissue engineering scaffolds. The chloroform solution of biodegradable poly(ether ester) poly(ethylene glycol terephthalate)/poly(butylene terephthalate)(PEGT/PBT) was nebulized to give fibers in the nitrogen current and subsequently to accumulate into non-woven scaffolds. At the same time, the hyaluronic acid(HA) aqueous solution was sprayed onto the surface of the resulted fibers to form more biocompatible scaffolds. The implant experiments indicated that these scaffolds were perfect in biocompatibility. HA used as an extracellular matrix improved the biocompatibility of the non-woven scaffolds.

Key words: Solution spray, PEGT/PBT, Tissue engineering, Non-woven scaffold, Biocompatibility

CLC Number:

R318.08

TrendMD:

LIU Hou-Li, CHEN Jin-Wu, WANG Lian-Cai, WANG Chang-Yong, FENG Zeng-Guo. Preparation of PEGT/PBT Tissue Engineering Scaffolds by Solution Spray Method[J]. Chem. J. Chinese Universities, 2005, 26(1): 175.

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Preparation of PEGT/PBT Tissue Engineering Scaffolds by Solution Spray Method

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