Chem. J. Chinese Universities ›› 2017, Vol. 38 ›› Issue (5): 872.doi: 10.7503/cjcu20160905

• Polymer Chemistry • Previous Articles     Next Articles

Synthesis and Characterization of Injectable Poly(L-glutamic acid) Hydrogels

LI Xing, YAN Shifeng, JIAN Yuhang, YIN Jingbo   

  1. Department of Polymer Materials, Shanghai University, Shanghai 200444, China
  • Received:2016-12-16 Revised:2017-03-16 Online:2017-05-10 Published:2017-03-16
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.51473090, 51373094), the Natural Science Foundation of Shanghai City, China(No.14ZR1414600) and the Science and Technology Commission of Shanghai Municipality, China(No.15JC1490400).

Abstract:

Adipic dihydrazide-modified PLGA(PLGA-ADH) and 3-amino-1,2-propanediol-modified PLGA were prepared by the activation of poly-L-glutamic acid(PLGA), the latter was further oxidized by sodium periodate to obtain aldehyde-modified PLGA(PLGA-CHO). Then, the two precursors including PLGA-ADH and PLGA-CHO were mixed to construct the injectable hydrogel by Schiff base reaction. The effects of solid content on the gelation time, swelling behavior, mechanical properties, in vitro degradation properties and microstructure of PLGA were investigated. Encapsulation of rabbit chondrocytes within the hydrogels showed cytocompatibility of the injectable hydrogels. A preliminary study exhibited in vivo injectability and mechanical stability of the hydrogels. The PLGA injectable hydrogel has a good application prospect in the field of tissue engineering.

Key words: Poly(L-glutamic acid), Injectable hydrogel, Tissue engineering

CLC Number: 

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