Preparation and Applications of Stretchable and Tough Hydrogels †

doi:10.7503/cjcu20190656

Abstract

Abstract:

In this review, we focus on the design principle of stretchable and tough hydrogels as well as the applications in the fields of tissue engineering and flexible electronic devices. Through connecting hydrogel network structures, toughening mechanisms and chemical structures with macroscopic mechanical properties, we mainly discussed the research progress of single network hydrogel, double network hydrogel, nanocomposite hydrogel and so on. The summary and outlook of the new ideas and directions of stretchable and tough hydrogels were also demonstrated at last.

Key words: Tough hydrogel, Toughness enhance, Single network hydrogel, Double network hydrogel, Nanocomposite hydrogel, Tissue engineering, Flexible electronic device

CLC Number:

TrendMD:

SHENG Hui, XUE Bin, QIN Meng, WANG Wei, CAO Yi. Preparation and Applications of Stretchable and Tough Hydrogels ^†[J]. Chem. J. Chinese Universities, 2020, 41(6): 1194.

Figures/Tables 10

References 111

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Classification	Sample code	Young’s modulus/MPa	Break strain/ (mm·mm^-1)	Fracture strength/MPa	Toughness/ (MJ·m^-3)	Fracture energy/ (kJ·m^-2)
Single network	CB[8]-PAM^[49]	0.02—0.42	107	1.8	——	——
hydrogel	PAM-peptide-Zn^2+[50]	0.01—0.12	4.3—7.8	0.2—0.56	——	0.63—1.35
	P(NaSS-co-MPTC)^[51]	1.53	9.4	2.6	——	4
	DMAA-co-MAAc^[52]	28	ca.8	2	——	9.3
Double network	PAMPS/PAAm^[53]	0.1—10	10—20	1—10	——	0.1—4.4
hydrogel	Alginate/PAAm^[24]	0.029	23	0.156	——	8.7
	PS-DN(compression)^[54]	0.32—0.57	——	0.21—1.6	——	0.3—2.67
	Crystallized PVA/PAAm^[55]	5	ca.3.8	2.5	——	14
	Agar/PAAm^[56]	0.082	20	1	9	——
	Agar/HPAM^[57]	0.106	52.6	0.267	9.35	1
Nanocomposite	PAM/CNS^[58]	ca. 0.1	121	0.43	33.9	——
hydrogel	NPs-P-PAA^[59]	ca.0.02	26	0.11	——	5.5
	Oxidized CNT/PAACA^[60]	0.028	14.1	0.364	——	——
	Clay-PNIPA^[61]	0.1—1	10—20	>1	ca.10	——
	PDA-pGO-PAM^[62]	ca.0.01	>35	ca.0.17	——	6.78
	P(BMA-co-AA)/PAM^[63]	0.028	17.4	0.74	ca.6	——
	(PDDA/PEI)-(PSS/PAA)^[64]	0.36±0.03	24.3±1.5	1.26±0.06	19.53±0.48	——
Other hydrogel	NIPA-AAcNa-HPR-C^[65]	ca.0.01	ca.15	ca.0.033	——	——
	Carboxyl-Fe³⁺/PR^[38]	8.3	5	4	——	10
	Tetra-PEG^[36]	0.054	7.4	0.136	0.59	——
	Tetra-PEG Protein^[66]	0.027	2.5	0.035	——	——

Classification	Sample code	Young’s modulus/MPa	Break strain/ (mm·mm^-1)	Fracture strength/MPa	Toughness/ (MJ·m^-3)	Fracture energy/ (kJ·m^-2)
Single network	CB[8]-PAM^[49]	0.02—0.42	107	1.8	——	——
hydrogel	PAM-peptide-Zn^2+[50]	0.01—0.12	4.3—7.8	0.2—0.56	——	0.63—1.35
	P(NaSS-co-MPTC)^[51]	1.53	9.4	2.6	——	4
	DMAA-co-MAAc^[52]	28	ca.8	2	——	9.3
Double network	PAMPS/PAAm^[53]	0.1—10	10—20	1—10	——	0.1—4.4
hydrogel	Alginate/PAAm^[24]	0.029	23	0.156	——	8.7
	PS-DN(compression)^[54]	0.32—0.57	——	0.21—1.6	——	0.3—2.67
	Crystallized PVA/PAAm^[55]	5	ca.3.8	2.5	——	14
	Agar/PAAm^[56]	0.082	20	1	9	——
	Agar/HPAM^[57]	0.106	52.6	0.267	9.35	1
Nanocomposite	PAM/CNS^[58]	ca. 0.1	121	0.43	33.9	——
hydrogel	NPs-P-PAA^[59]	ca.0.02	26	0.11	——	5.5
	Oxidized CNT/PAACA^[60]	0.028	14.1	0.364	——	——
	Clay-PNIPA^[61]	0.1—1	10—20	>1	ca.10	——
	PDA-pGO-PAM^[62]	ca.0.01	>35	ca.0.17	——	6.78
	P(BMA-co-AA)/PAM^[63]	0.028	17.4	0.74	ca.6	——
	(PDDA/PEI)-(PSS/PAA)^[64]	0.36±0.03	24.3±1.5	1.26±0.06	19.53±0.48	——
Other hydrogel	NIPA-AAcNa-HPR-C^[65]	ca.0.01	ca.15	ca.0.033	——	——
	Carboxyl-Fe³⁺/PR^[38]	8.3	5	4	——	10
	Tetra-PEG^[36]	0.054	7.4	0.136	0.59	——
	Tetra-PEG Protein^[66]	0.027	2.5	0.035	——	——